J Am Med Inform Assoc - Advantages of genomic complexity: bioinformatics opportunities in microRNA cancer signatures.

Tópicos

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Resumo

MicroRNAs, small non-coding RNAs, may act as tumor suppressors or oncogenes, and each regulate their own transcription and that of hundreds of genes, often in a tissue-dependent manner. This creates a tightly interwoven network regulating and underlying oncogenesis and cancer biology. Although protein-coding gene signatures and single protein pathway markers have proliferated over the past decade, routine adoption of the former has been hampered by interpretability, reproducibility, and dimensionality, whereas the single molecule-phenotype reductionism of the latter is often overly simplistic to account for complex phenotypes. MicroRNA-derived biomarkers offer a powerful alternative; they have both the flexibility of gene expression signature classifiers and the desirable mechanistic transparency of single protein biomarkers. Furthermore, several advances have recently demonstrated the robust detection of microRNAs from various biofluids, thus providing an additional opportunity for obtaining bioinformatically derived biomarkers to accelerate the identification of individual patients for personalized therapy.

Resumo Limpo

microrna small noncod rnas may act tumor suppressor oncogen regul transcript hundr gene often tissuedepend manner creat tight interwoven network regul under oncogenesi cancer biolog although proteincod gene signatur singl protein pathway marker prolifer past decad routin adopt former hamper interpret reproduc dimension wherea singl moleculephenotyp reduction latter often over simplist account complex phenotyp micrornaderiv biomark offer power altern flexibl gene express signatur classifi desir mechanist transpar singl protein biomark furthermor sever advanc recent demonstr robust detect microrna various biofluid thus provid addit opportun obtain bioinformat deriv biomark acceler identif individu patient person therapi

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