J Am Med Inform Assoc - Toward personalizing treatment for depression: predicting diagnosis and severity.


{ treatment(1704) effect(941) patient(846) }
{ model(2341) predict(2261) use(1141) }
{ case(1353) use(1143) diagnosi(1136) }
{ sequenc(1873) structur(1644) protein(1328) }
{ patient(2837) hospit(1953) medic(668) }
{ record(1888) medic(1808) patient(1693) }
{ research(1085) discuss(1038) issu(1018) }
{ activ(1452) weight(1219) physic(1104) }
{ can(774) often(719) complex(702) }
{ blood(1257) pressur(1144) flow(957) }
{ ehr(2073) health(1662) electron(1139) }
{ health(1844) social(1437) communiti(874) }
{ age(1611) year(1155) adult(843) }
{ patient(2315) diseas(1263) diabet(1191) }
{ take(945) account(800) differ(722) }
{ control(1307) perform(991) simul(935) }
{ howev(809) still(633) remain(590) }
{ perform(999) metric(946) measur(919) }
{ intervent(3218) particip(2042) group(1664) }
{ analysi(2126) use(1163) compon(1037) }
{ cancer(2502) breast(956) screen(824) }
{ implement(1333) system(1263) develop(1122) }
{ data(1737) use(1416) pattern(1282) }
{ system(1976) rule(880) can(841) }
{ measur(2081) correl(1212) valu(896) }
{ problem(2511) optim(1539) algorithm(950) }
{ error(1145) method(1030) estim(1020) }
{ clinic(1479) use(1117) guidelin(835) }
{ data(3963) clinic(1234) research(1004) }
{ visual(1396) interact(850) tool(830) }
{ perform(1367) use(1326) method(1137) }
{ data(2317) use(1299) case(1017) }
{ activ(1138) subject(705) human(624) }
{ use(976) code(926) identifi(902) }
{ model(3404) distribut(989) bayesian(671) }
{ imag(1947) propos(1133) code(1026) }
{ inform(2794) health(2639) internet(1427) }
{ imag(1057) registr(996) error(939) }
{ bind(1733) structur(1185) ligand(1036) }
{ method(1219) similar(1157) match(930) }
{ featur(3375) classif(2383) classifi(1994) }
{ imag(2830) propos(1344) filter(1198) }
{ network(2748) neural(1063) input(814) }
{ imag(2675) segment(2577) method(1081) }
{ studi(2440) review(1878) systemat(933) }
{ motion(1329) object(1292) video(1091) }
{ assess(1506) score(1403) qualiti(1306) }
{ surgeri(1148) surgic(1085) robot(1054) }
{ framework(1458) process(801) describ(734) }
{ chang(1828) time(1643) increas(1301) }
{ learn(2355) train(1041) set(1003) }
{ concept(1167) ontolog(924) domain(897) }
{ algorithm(1844) comput(1787) effici(935) }
{ extract(1171) text(1153) clinic(932) }
{ method(1557) propos(1049) approach(1037) }
{ data(1714) softwar(1251) tool(1186) }
{ design(1359) user(1324) use(1319) }
{ model(2220) cell(1177) simul(1124) }
{ care(1570) inform(1187) nurs(1089) }
{ general(901) number(790) one(736) }
{ method(984) reconstruct(947) comput(926) }
{ search(2224) databas(1162) retriev(909) }
{ featur(1941) imag(1645) propos(1176) }
{ studi(1410) differ(1259) use(1210) }
{ risk(3053) factor(974) diseas(938) }
{ system(1050) medic(1026) inform(1018) }
{ import(1318) role(1303) understand(862) }
{ compound(1573) activ(1297) structur(1058) }
{ studi(1119) effect(1106) posit(819) }
{ spatial(1525) area(1432) region(1030) }
{ health(3367) inform(1360) care(1135) }
{ model(3480) simul(1196) paramet(876) }
{ monitor(1329) mobil(1314) devic(1160) }
{ state(1844) use(1261) util(961) }
{ research(1218) medic(880) student(794) }
{ model(2656) set(1616) predict(1553) }
{ medic(1828) order(1363) alert(1069) }
{ signal(2180) analysi(812) frequenc(800) }
{ cost(1906) reduc(1198) effect(832) }
{ group(2977) signific(1463) compar(1072) }
{ sampl(1606) size(1419) use(1276) }
{ gene(2352) biolog(1181) express(1162) }
{ data(3008) multipl(1320) sourc(1022) }
{ first(2504) two(1366) second(1323) }
{ time(1939) patient(1703) rate(768) }
{ patient(1821) servic(1111) care(1106) }
{ use(2086) technolog(871) perceiv(783) }
{ can(981) present(881) function(850) }
{ structur(1116) can(940) graph(676) }
{ high(1669) rate(1365) level(1280) }
{ use(1733) differ(960) four(931) }
{ drug(1928) target(777) effect(648) }
{ result(1111) use(1088) new(759) }
{ survey(1388) particip(1329) question(1065) }
{ estim(2440) model(1874) function(577) }
{ decis(3086) make(1611) patient(1517) }
{ process(1125) use(805) approach(778) }
{ method(1969) cluster(1462) data(1082) }
{ method(2212) result(1239) propos(1039) }
{ detect(2391) sensit(1101) algorithm(908) }


JECTIVE: Depression is a prevalent disorder difficult to diagnose and treat. In particular, depressed patients exhibit largely unpredictable responses to treatment. Toward the goal of personalizing treatment for depression, we develop and evaluate computational models that use electronic health record (EHR) data for predicting the diagnosis and severity of depression, and response to treatment.MATERIALS AND METHODS: We develop regression-based models for predicting depression, its severity, and response to treatment from EHR data, using structured diagnosis and medication codes as well as free-text clinical reports. We used two datasets: 35,000 patients (5000 depressed) from the Palo Alto Medical Foundation and 5651 patients treated for depression from the Group Health Research Institute.RESULTS: Our models are able to predict a future diagnosis of depression up to 12 months in advance (area under the receiver operating characteristic curve (AUC) 0.70-0.80). We can differentiate patients with severe baseline depression from those with minimal or mild baseline depression (AUC 0.72). Baseline depression severity was the strongest predictor of treatment response for medication and psychotherapy.CONCLUSIONS: It is possible to use EHR data to predict a diagnosis of depression up to 12 months in advance and to differentiate between extreme baseline levels of depression. The models use commonly available data on diagnosis, medication, and clinical progress notes, making them easily portable. The ability to automatically determine severity can facilitate assembly of large patient cohorts with similar severity from multiple sites, which may enable elucidation of the moderators of treatment response in the future.

Resumo Limpo

jectiv depress preval disord difficult diagnos treat particular depress patient exhibit larg unpredict respons treatment toward goal person treatment depress develop evalu comput model use electron health record ehr data predict diagnosi sever depress respons treatmentmateri method develop regressionbas model predict depress sever respons treatment ehr data use structur diagnosi medic code well freetext clinic report use two dataset patient depress palo alto medic foundat patient treat depress group health research instituteresult model abl predict futur diagnosi depress month advanc area receiv oper characterist curv auc can differenti patient sever baselin depress minim mild baselin depress auc baselin depress sever strongest predictor treatment respons medic psychotherapyconclus possibl use ehr data predict diagnosi depress month advanc differenti extrem baselin level depress model use common avail data diagnosi medic clinic progress note make easili portabl abil automat determin sever can facilit assembl larg patient cohort similar sever multipl site may enabl elucid moder treatment respons futur

Resumos Similares

Artif Intell Med - Artificial metaplasticity prediction model for cognitive rehabilitation outcome in acquired brain injury patients. ( 0,809427213400379 )
J. Med. Internet Res. - Comparing in-person to videoconference-based cognitive behavioral therapy for mood and anxiety disorders: randomized controlled trial. ( 0,787792003546572 )
J. Med. Internet Res. - Mining online social network data for biomedical research: a comparison of clinicians' and patients' perceptions about amyotrophic lateral sclerosis treatments. ( 0,779779917981013 )
J. Med. Internet Res. - Posttreatment attrition and its predictors, attrition bias, and treatment efficacy of the anxiety online programs. ( 0,77645566264362 )
J. Med. Internet Res. - Cost-utility and cost-effectiveness of internet-based treatment for adults with depressive symptoms: randomized trial. ( 0,756149746336065 )
J. Med. Internet Res. - Internet-based cognitive behavioral therapy for patients with chronic somatic conditions: a meta-analytic review. ( 0,75241859140395 )
Med Biol Eng Comput - Assessing the effectiveness of robot facilitated neurorehabilitation for relearning motor skills following a stroke. ( 0,747170005280798 )
J. Med. Internet Res. - Internet-delivered interpersonal psychotherapy versus internet-delivered cognitive behavioral therapy for adults with depressive symptoms: randomized controlled noninferiority trial. ( 0,741583675687698 )
IEEE J Biomed Health Inform - Estimation and prediction of drug therapy on the termination of atrial fibrillation by autoregressive model with exogenous inputs. ( 0,738722677702723 )
J. Med. Internet Res. - Pretreatment attrition and formal withdrawal during treatment and their predictors: an exploratory study of the anxiety online data. ( 0,736402695011093 )
Med Decis Making - Do clinical psychologists extend the bereavement exclusion for major depression to other stressful life events? ( 0,728831302068667 )
Telemed J E Health - Telemedicine-based treatment versus hospitalization in patients with severe chronic obstructive pulmonary disease and exacerbation: effect on cognitive function. A randomized clinical trial. ( 0,723954843565436 )
J. Med. Internet Res. - Internet-based motivation program for women with eating disorders: eating disorder pathology and depressive mood predict dropout. ( 0,720567685715348 )
J. Med. Internet Res. - Effectiveness of an online group course for depression in adolescents and young adults: a randomized trial. ( 0,719217600861679 )
J Telemed Telecare - Email reminders as a self-management tool in depression: a needs assessment to determine patients' interests and preferences. ( 0,713656541000276 )
Artif Intell Med - Unveiling relevant non-motor Parkinson's disease severity symptoms using a machine learning approach. ( 0,711391107983684 )
J. Med. Internet Res. - Activities on Facebook reveal the depressive state of users. ( 0,706039031110354 )
J. Med. Internet Res. - Effectiveness of a web-based solution-focused brief chat treatment for depressed adolescents and young adults: randomized controlled trial. ( 0,705155166118816 )
J. Med. Internet Res. - Acceptability of a clinician-assisted computerized psychological intervention for comorbid mental health and substance use problems: treatment adherence data from a randomized controlled trial. ( 0,704800458172373 )
J. Med. Internet Res. - Is a severe clinical profile an effect modifier in a Web-based depression treatment for adults with type 1 or type 2 diabetes? Secondary analyses from a randomized controlled trial. ( 0,697023854000255 )
J Clin Monit Comput - Comprehensive diagnosis of whole-body acid-base and fluid-electrolyte disorders using a mathematical model and whole-body base excess. ( 0,694364029176831 )
J. Med. Internet Res. - An Internet-based intervention to promote mental fitness for mildly depressed adults: randomized controlled trial. ( 0,692732954255601 )
J Clin Monit Comput - The accuracy of respiratory rate assessment by doctors in a London teaching hospital: a cross-sectional study. ( 0,689981387430839 )
J. Med. Internet Res. - Development and initial evaluation of an Internet-based support system for face-to-face cognitive behavior therapy: a proof of concept study. ( 0,682817621436975 )
Comput Methods Programs Biomed - First pilot trial of the STAR-Liege protocol for tight glycemic control in critically ill patients. ( 0,681650258062238 )
J. Med. Internet Res. - The clinical effectiveness of web-based cognitive behavioral therapy with face-to-face therapist support for depressed primary care patients: randomized controlled trial. ( 0,681463502027659 )
J. Med. Internet Res. - Chinese My Trauma Recovery, a Web-based intervention for traumatized persons in two parallel samples: randomized controlled trial. ( 0,671617833588353 )
Telemed J E Health - Are e-health web users looking for different symptom information than callers to triage centers? ( 0,668263676885637 )
J. Med. Internet Res. - Methodological issues in Internet-mediated research: a randomized comparison of internet versus mailed questionnaires. ( 0,66642900113548 )
J. Med. Internet Res. - Comorbidity structure of psychological disorders in the online e-PASS data as predictors of psychosocial adjustment measures: psychological distress, adequate social support, self-confidence, quality of life, and suicidal ideation. ( 0,65824461266521 )
BMC Med Inform Decis Mak - Development and validation of an algorithm to recalibrate mental models and reduce diagnostic errors associated with catheter-associated bacteriuria. ( 0,654832242885727 )
J. Med. Internet Res. - Patients' experiences of helpfulness in guided internet-based treatment for depression: qualitative study of integrated therapeutic dimensions. ( 0,650193633691531 )
J. Med. Internet Res. - Effects of a multilingual information website intervention on the levels of depression literacy and depression-related stigma in Greek-born and Italian-born immigrants living in Australia: a randomized controlled trial. ( 0,647924052896719 )
J. Med. Internet Res. - Short-term effects of a web-based guided self-help intervention for employees with depressive symptoms: randomized controlled trial. ( 0,647327540582752 )
J. Med. Internet Res. - Quantifying short-term dynamics of Parkinson's disease using self-reported symptom data from an Internet social network. ( 0,644791333097928 )
J Telemed Telecare - Telephone-delivered cognitive behavioural therapy: a systematic review and meta-analysis. ( 0,639785316097526 )
J. Med. Internet Res. - An Internet-based guided self-help intervention for panic symptoms: randomized controlled trial. ( 0,633016195243518 )
J Telemed Telecare - A pilot study of a mobile-phone-based home monitoring system to assist in remote interventions in cases of acute exacerbation of COPD. ( 0,632897774154493 )
Med Decis Making - Cross-cultural evaluation of the WHOQOL-BREF domains in primary care depressed patients using Rasch analysis. ( 0,63163673039922 )
J. Med. Internet Res. - Telephone versus internet administration of self-report measures of social anxiety, depressive symptoms, and insomnia: psychometric evaluation of a method to reduce the impact of missing data. ( 0,630893268144045 )
Med Decis Making - Validation of SURE, a four-item clinical checklist for detecting decisional conflict in patients. ( 0,630396669229459 )
J. Med. Internet Res. - Comparing effects in regular practice of e-communication and Web-based self-management support among breast cancer patients: preliminary results from a randomized controlled trial. ( 0,625751663141777 )
J. Med. Internet Res. - For whom does it work? moderators of outcome on the effect of a transdiagnostic internet-based maintenance treatment after inpatient psychotherapy: randomized controlled trial. ( 0,623464003694937 )
Methods Inf Med - The nested structure of cancer symptoms. Implications for analyzing co-occurrence and managing symptoms. ( 0,619982032020933 )
Med Biol Eng Comput - Using reduced rule base with Expert System for the diagnosis of disease in hypertension. ( 0,618506536400764 )
Comput Methods Programs Biomed - A SAS macro for a clustered logrank test. ( 0,617543859649123 )
Telemed J E Health - Posttraumatic stress disorder treatment for Operation Enduring Freedom/Operation Iraqi Freedom combat veterans through a civilian community-based telemedicine network. ( 0,615940210956682 )
Telemed J E Health - A study on the effectiveness of videoconferencing on teaching parent training skills to parents of children with ADHD. ( 0,609739295282844 )
J. Med. Internet Res. - Attrition in web-based treatment for problem drinkers. ( 0,606488352886419 )
J Biomed Inform - Avatar-based simulation in the evaluation of diagnosis and management of mental health disorders in primary care. ( 0,60489604622599 )
J. Med. Internet Res. - Web-based treatment program using intensive therapeutic contact for patients with eating disorders: before-after study. ( 0,602491998674068 )
J Med Syst - Summarizing phenotype evolution patterns from report cases. ( 0,601991737208459 )
Telemed J E Health - Faked depression: comparing malingering via the internet, pen-and-paper, and telephone administration modes. ( 0,600912834559967 )
J. Med. Internet Res. - Multimodal e-mental health treatment for depression: a feasibility trial. ( 0,599511693140018 )
Med Decis Making - Exploring the response shift effect on the quality of life of patients with schizophrenia: an application of the random forest method. ( 0,598796167439821 )
BMC Med Inform Decis Mak - The Tinnitus Research Initiative (TRI) database: a new approach for delineation of tinnitus subtypes and generation of predictors for treatment outcome. ( 0,596560583510813 )
J Am Med Inform Assoc - mHealth interventions for weight loss: a guide for achieving treatment fidelity. ( 0,590862293746082 )
Int J Med Inform - Support system for decision making in the identification of risk for body dysmorphic disorder: a fuzzy model. ( 0,589916573181519 )
J Clin Monit Comput - Cardiac asynchrony in Duchenne muscular dystrophy. ( 0,585941339877986 )
Comput Math Methods Med - Coarse-grained multifractality analysis based on structure function measurements to discriminate healthy from distressed foetuses. ( 0,585615171233973 )
J. Med. Internet Res. - A comparison of two delivery modalities of a mobile phone-based assessment for serious mental illness: native smartphone application vs text-messaging only implementations. ( 0,585239531908744 )
Artif Intell Med - Mood recognition in bipolar patients through the PSYCHE platform: preliminary evaluations and perspectives. ( 0,583186290510684 )
J. Med. Internet Res. - Virtual reality for enhancing the cognitive behavioral treatment of obesity with binge eating disorder: randomized controlled study with one-year follow-up. ( 0,582310117726194 )
J. Med. Internet Res. - How feedback biases give ineffective medical treatments a good reputation. ( 0,581974422133115 )
Comput Math Methods Med - Haptic-based neurorehabilitation in poststroke patients: a feasibility prospective multicentre trial for robotics hand rehabilitation. ( 0,580244847533417 )
J. Med. Internet Res. - Maximizing the value of mobile health monitoring by avoiding redundant patient reports: prediction of depression-related symptoms and adherence problems in automated health assessment services. ( 0,579484685995033 )
J Am Med Inform Assoc - Calibrating predictive model estimates to support personalized medicine. ( 0,579185543029401 )
Med Decis Making - Knowledge, attitudes, and self-efficacy as predictors of preparedness for oncology clinical trials: a mediational model. ( 0,578148867267551 )
Telemed J E Health - Effect of home telemonitoring on glycemic and blood pressure control in primary care clinic patients with diabetes. ( 0,576627548612277 )
J Med Syst - Designing a decision support system for distinguishing ADHD from similar children behavioral disorders. ( 0,574663763784864 )
J. Med. Internet Res. - Harnessing context sensing to develop a mobile intervention for depression. ( 0,574317230023403 )
Methods Inf Med - Relationship between malocclusion and heart rate variability indices in young adults: a pilot study. ( 0,5739824007351 )
J Telemed Telecare - Validity of a simple Internet-based outcome-prediction tool in patients with total hip replacement: a pilot study. ( 0,572889204864552 )
J. Med. Internet Res. - Long-term results of a web-based guided self-help intervention for employees with depressive symptoms: randomized controlled trial. ( 0,571563650766543 )
J. Med. Internet Res. - Anxiety online: a virtual clinic: preliminary outcomes following completion of five fully automated treatment programs for anxiety disorders and symptoms. ( 0,570673751510484 )
Comput Methods Programs Biomed - Software for symptom association analysis in pediatric gastroesophageal reflux disease. ( 0,568639596857402 )
Telemed J E Health - A randomized controlled trial of an internet-based posttreatment care for patients with eating disorders. ( 0,56664289275491 )
J. Med. Internet Res. - Effect of a Kinect-based exercise game on improving executive cognitive performance in community-dwelling elderly: case control study. ( 0,565001463784957 )
J. Med. Internet Res. - Rethinking the dose-response relationship between usage and outcome in an online intervention for depression: randomized controlled trial. ( 0,564885926395602 )
J. Med. Internet Res. - Working alliance in online cognitive behavior therapy for anxiety disorders in youth: comparison with clinic delivery and its role in predicting outcome. ( 0,558773710031456 )
Comput Methods Programs Biomed - Computer simulation of structured treatment interruption for HIV infection. ( 0,555495525526523 )
IEEE J Biomed Health Inform - Complexity index from a personalized wearable monitoring system for assessing remission in mental health. ( 0,553943228786461 )
Telemed J E Health - Telemental health evaluations enhance access and efficiency in a critical access hospital emergency department. ( 0,553418426549322 )
Comput Math Methods Med - A clinical decision support system for femoral peripheral arterial disease treatment. ( 0,550062497034412 )
Med Biol Eng Comput - Advances in upper limb stroke rehabilitation: a technology push. ( 0,549213182911069 )
Int J Health Geogr - Spatial analysis of learning and developmental disorders in upper Cape Cod, Massachusetts using generalized additive models. ( 0,546990624349698 )
Telemed J E Health - The effectiveness and feasibility of videoconferencing technology to provide evidence-based treatment to rural domestic violence and sexual assault populations. ( 0,546568545762123 )
J Am Med Inform Assoc - Patient-reported outcome measures: an on-line system empowering patient choice. ( 0,544635636720617 )
J Biomed Inform - How cytokines co-occur across asthma patients: from bipartite network analysis to a molecular-based classification. ( 0,544372271689461 )
Comput Math Methods Med - Multicriteria optimization model for the study of the efficacy of skin antiaging therapy. ( 0,543924727289174 )
J. Med. Internet Res. - Self-monitoring using mobile phones in the early stages of adolescent depression: randomized controlled trial. ( 0,542361873330347 )
J Clin Monit Comput - Outcome impact of goal directed fluid therapy during high risk abdominal surgery in low to moderate risk patients: a randomized controlled trial. ( 0,542108932106469 )
J. Med. Internet Res. - Online cognitive behavioral therapy for bulimic type disorders, delivered in the community by a nonclinician: qualitative study. ( 0,541872676307859 )
Telemed J E Health - Who is being reached for a telephone-delivered intervention for patients with uncontrolled hypertension? ( 0,541831846346619 )
J. Med. Internet Res. - Physiological and brain activity after a combined cognitive behavioral treatment plus video game therapy for emotional regulation in bulimia nervosa: a case report. ( 0,541288360102601 )
Med Decis Making - Crediting treatments for good outcomes that would have happened anyway: the impact of baseline risk on treatment perceptions. ( 0,540841204944182 )
Comput Methods Programs Biomed - Diagnosis support system based on clinical guidelines: comparison between case-based fuzzy cognitive maps and Bayesian networks. ( 0,536342755522874 )
J. Med. Internet Res. - Understanding the usage of content in a mental health intervention for depression: an analysis of log data. ( 0,535952891524757 )
J. Med. Internet Res. - Internet-based early intervention to prevent posttraumatic stress disorder in injury patients: randomized controlled trial. ( 0,535150419772605 )
J Clin Monit Comput - Bedside monitoring of ventilation distribution and alveolar inflammation in community-acquired pneumonia. ( 0,534791216024387 )