J Am Med Inform Assoc - Clinical decision support for genetically guided personalized medicine: a systematic review.

Tópicos

{ studi(2440) review(1878) systemat(933) }
{ clinic(1479) use(1117) guidelin(835) }
{ implement(1333) system(1263) develop(1122) }
{ care(1570) inform(1187) nurs(1089) }
{ gene(2352) biolog(1181) express(1162) }
{ studi(1119) effect(1106) posit(819) }
{ health(1844) social(1437) communiti(874) }
{ imag(2675) segment(2577) method(1081) }
{ howev(809) still(633) remain(590) }
{ studi(1410) differ(1259) use(1210) }
{ research(1085) discuss(1038) issu(1018) }
{ data(3008) multipl(1320) sourc(1022) }
{ use(1733) differ(960) four(931) }
{ decis(3086) make(1611) patient(1517) }
{ system(1976) rule(880) can(841) }
{ featur(3375) classif(2383) classifi(1994) }
{ framework(1458) process(801) describ(734) }
{ chang(1828) time(1643) increas(1301) }
{ concept(1167) ontolog(924) domain(897) }
{ search(2224) databas(1162) retriev(909) }
{ model(2341) predict(2261) use(1141) }
{ visual(1396) interact(850) tool(830) }
{ compound(1573) activ(1297) structur(1058) }
{ blood(1257) pressur(1144) flow(957) }
{ state(1844) use(1261) util(961) }
{ research(1218) medic(880) student(794) }
{ cost(1906) reduc(1198) effect(832) }
{ group(2977) signific(1463) compar(1072) }
{ patient(1821) servic(1111) care(1106) }
{ use(2086) technolog(871) perceiv(783) }
{ analysi(2126) use(1163) compon(1037) }
{ cancer(2502) breast(956) screen(824) }
{ use(976) code(926) identifi(902) }
{ method(2212) result(1239) propos(1039) }
{ model(3404) distribut(989) bayesian(671) }
{ can(774) often(719) complex(702) }
{ imag(1947) propos(1133) code(1026) }
{ data(1737) use(1416) pattern(1282) }
{ inform(2794) health(2639) internet(1427) }
{ measur(2081) correl(1212) valu(896) }
{ imag(1057) registr(996) error(939) }
{ bind(1733) structur(1185) ligand(1036) }
{ sequenc(1873) structur(1644) protein(1328) }
{ method(1219) similar(1157) match(930) }
{ imag(2830) propos(1344) filter(1198) }
{ network(2748) neural(1063) input(814) }
{ patient(2315) diseas(1263) diabet(1191) }
{ take(945) account(800) differ(722) }
{ motion(1329) object(1292) video(1091) }
{ assess(1506) score(1403) qualiti(1306) }
{ treatment(1704) effect(941) patient(846) }
{ surgeri(1148) surgic(1085) robot(1054) }
{ problem(2511) optim(1539) algorithm(950) }
{ error(1145) method(1030) estim(1020) }
{ learn(2355) train(1041) set(1003) }
{ algorithm(1844) comput(1787) effici(935) }
{ extract(1171) text(1153) clinic(932) }
{ method(1557) propos(1049) approach(1037) }
{ data(1714) softwar(1251) tool(1186) }
{ design(1359) user(1324) use(1319) }
{ control(1307) perform(991) simul(935) }
{ model(2220) cell(1177) simul(1124) }
{ general(901) number(790) one(736) }
{ method(984) reconstruct(947) comput(926) }
{ featur(1941) imag(1645) propos(1176) }
{ case(1353) use(1143) diagnosi(1136) }
{ data(3963) clinic(1234) research(1004) }
{ risk(3053) factor(974) diseas(938) }
{ perform(999) metric(946) measur(919) }
{ system(1050) medic(1026) inform(1018) }
{ import(1318) role(1303) understand(862) }
{ perform(1367) use(1326) method(1137) }
{ spatial(1525) area(1432) region(1030) }
{ record(1888) medic(1808) patient(1693) }
{ health(3367) inform(1360) care(1135) }
{ model(3480) simul(1196) paramet(876) }
{ monitor(1329) mobil(1314) devic(1160) }
{ ehr(2073) health(1662) electron(1139) }
{ patient(2837) hospit(1953) medic(668) }
{ model(2656) set(1616) predict(1553) }
{ data(2317) use(1299) case(1017) }
{ age(1611) year(1155) adult(843) }
{ medic(1828) order(1363) alert(1069) }
{ signal(2180) analysi(812) frequenc(800) }
{ sampl(1606) size(1419) use(1276) }
{ first(2504) two(1366) second(1323) }
{ intervent(3218) particip(2042) group(1664) }
{ activ(1138) subject(705) human(624) }
{ time(1939) patient(1703) rate(768) }
{ can(981) present(881) function(850) }
{ structur(1116) can(940) graph(676) }
{ high(1669) rate(1365) level(1280) }
{ drug(1928) target(777) effect(648) }
{ result(1111) use(1088) new(759) }
{ survey(1388) particip(1329) question(1065) }
{ estim(2440) model(1874) function(577) }
{ process(1125) use(805) approach(778) }
{ activ(1452) weight(1219) physic(1104) }
{ method(1969) cluster(1462) data(1082) }
{ detect(2391) sensit(1101) algorithm(908) }

Resumo

JECTIVE: To review the literature on clinical decision support (CDS) for genetically guided personalized medicine (GPM).MATERIALS AND METHODS: MEDLINE and Embase were searched from 1990 to 2011. The manuscripts included were summarized, and notable themes and trends were identified.RESULTS: Following a screening of 3416 articles, 38 primary research articles were identified. Focal areas of research included family history-driven CDS, cancer management, and pharmacogenomics. Nine randomized controlled trials of CDS interventions for GPM were identified, seven of which reported positive results. The majority of manuscripts were published on or after 2007, with increased recent focus on genotype-driven CDS and the integration of CDS within primary clinical information systems.DISCUSSION: Substantial research has been conducted to date on the use of CDS to enable GPM. In a previous analysis of CDS intervention trials, the automatic provision of CDS as a part of routine clinical workflow had been identified as being critical for CDS effectiveness. There was some indication that CDS for GPM could potentially be effective without the CDS being provided automatically, but we did not find conclusive evidence to support this hypothesis.CONCLUSION: To maximize the clinical benefits arising from ongoing discoveries in genetics and genomics, additional research and development is recommended for identifying how best to leverage CDS to bridge the gap between the promise and realization of GPM.

Resumo Limpo

jectiv review literatur clinic decis support cds genet guid person medicin gpmmateri method medlin embas search manuscript includ summar notabl theme trend identifiedresult follow screen articl primari research articl identifi focal area research includ famili historydriven cds cancer manag pharmacogenom nine random control trial cds intervent gpm identifi seven report posit result major manuscript publish increas recent focus genotypedriven cds integr cds within primari clinic inform systemsdiscuss substanti research conduct date use cds enabl gpm previous analysi cds intervent trial automat provis cds part routin clinic workflow identifi critic cds effect indic cds gpm potenti effect without cds provid automat find conclus evid support hypothesisconclus maxim clinic benefit aris ongo discoveri genet genom addit research develop recommend identifi best leverag cds bridg gap promis realiz gpm

Resumos Similares

J. Med. Internet Res. - Effectiveness and cost-effectiveness of ehealth interventions in somatic diseases: a systematic review of systematic reviews and meta-analyses. ( 0,876714544721914 )
Res Synth Methods - Reporting quality of search methods in systematic reviews of HIV behavioral interventions (2000-2010): are the searches clearly explained, systematic and reproducible? ( 0,874457249813332 )
J Telemed Telecare - Telemedicine interventions for substance-use disorder: a literature review. ( 0,87066187912965 )
Telemed J E Health - Critical appraisal of published systematic reviews assessing the cost-effectiveness of telemedicine studies. ( 0,870195214259301 )
J. Med. Internet Res. - Systematic reviews and meta-analyses of home telemonitoring interventions for patients with chronic diseases: a critical assessment of their methodological quality. ( 0,865715080370535 )
Med Decis Making - It's Valid and Reliable Is Not Enough: Critical Appraisal of Reporting of Measures in Trials Evaluating Patient Decision Aids. ( 0,862714072033213 )
J Am Med Inform Assoc - Reducing caregiver stress with internet-based interventions: a systematic review of open-label and randomized controlled trials. ( 0,857356600772359 )
J. Med. Internet Res. - Electronic symptom reporting between patient and provider for improved health care service quality: a systematic review of randomized controlled trials. part 2: methodological quality and effects. ( 0,853814804052615 )
Res Synth Methods - Potential uses of Bayesian networks as tools for synthesis of systematic reviews of complex interventions. ( 0,84490761699376 )
Res Synth Methods - Issues relating to confounding and meta-analysis when including non-randomized studies in systematic reviews on the effects of interventions. ( 0,841476374824165 )
J Telemed Telecare - Evidence of benefit from telerehabilitation in routine care: a systematic review. ( 0,840421059820055 )
J Telemed Telecare - A systematic review of telehealth tools and interventions to support family caregivers. ( 0,832160700130897 )
Res Synth Methods - Clinical trial registries are of minimal use for identifying selective outcome and analysis reporting. ( 0,82546592347574 )
Res Synth Methods - An introduction to methodological issues when including non-randomised studies in systematic reviews on the effects of interventions. ( 0,823095240221263 )
Res Synth Methods - Issues relating to study design and risk of bias when including non-randomized studies in systematic reviews on the effects of interventions. ( 0,818007373771447 )
Med Decis Making - Interventions to improve patient comprehension in informed consent for medical and surgical procedures: a systematic review. ( 0,816173070730181 )
J. Med. Internet Res. - Digital asthma self-management interventions: a systematic review. ( 0,815760736684485 )
Appl Clin Inform - The impact of health information exchange on health outcomes. ( 0,811918948259956 )
Res Synth Methods - Issues relating to selective reporting when including non-randomized studies in systematic reviews on the effects of healthcare interventions. ( 0,811729784890418 )
Res Synth Methods - A method for evaluating research syntheses: The quality, conclusions, and consensus of 12 syntheses of the effects of after-school programs. ( 0,810267693113975 )
Res Synth Methods - A scoping review of scoping reviews: advancing the approach and enhancing the consistency. ( 0,808500535992551 )
J Telemed Telecare - Teledentistry: a systematic review of the literature. ( 0,808035932459197 )
Res Synth Methods - The role of systematic reviews of qualitative evidence in evaluating interventions: a case study. ( 0,807040054381091 )
J Am Med Inform Assoc - Systematic review and evaluation of web-accessible tools for management of diabetes and related cardiovascular risk factors by patients and healthcare providers. ( 0,806542618302011 )
Int J Med Inform - Methodologies for assessing telemedicine: a systematic review of reviews. ( 0,805647858003275 )
Med Decis Making - Methods for systematic reviews of health economic evaluations: a systematic review, comparison, and synthesis of method literature. ( 0,802928596428361 )
J. Med. Internet Res. - A systematic review of the impact of adherence on the effectiveness of e-therapies. ( 0,795008094789778 )
J Telemed Telecare - The effectiveness of helplines for the treatment of alcohol and illicit substance use. ( 0,794065966995661 )
Res Synth Methods - Multi-context versus context-specific qualitative evidence syntheses: combining the best of both. ( 0,792845981126193 )
J. Med. Internet Res. - Effectiveness of eHealth interventions and information needs in palliative care: a systematic literature review. ( 0,789711713582563 )
Res Synth Methods - Reporting standards for literature searches and report inclusion criteria: making research syntheses more transparent and easy to replicate. ( 0,787190586673315 )
BMC Med Inform Decis Mak - A systematic review of speech recognition technology in health care. ( 0,786476055919345 )
AMIA Annu Symp Proc - Exploring the use of social media to measure journal article impact. ( 0,781927481115804 )
J. Med. Internet Res. - Assessing the internal and external validity of mobile health physical activity promotion interventions: a systematic literature review using the RE-AIM framework. ( 0,778562235840436 )
J Am Med Inform Assoc - Effects of clinical decision-support systems on practitioner performance and patient outcomes: a synthesis of high-quality systematic review findings. ( 0,778275754447023 )
BMC Med Inform Decis Mak - ASCOT: a text mining-based web-service for efficient search and assisted creation of clinical trials. ( 0,777976125844654 )
BMC Med Inform Decis Mak - Is the coverage of Google Scholar enough to be used alone for systematic reviews. ( 0,776285184116132 )
J. Med. Internet Res. - Effects of eHealth interventions on medication adherence: a systematic review of the literature. ( 0,769846279990393 )
Telemed J E Health - Quality and methodological challenges in Internet-based mental health trials. ( 0,769556086945595 )
J. Med. Internet Res. - Online and social networking interventions for the treatment of depression in young people: a systematic review. ( 0,768319748182177 )
J. Med. Internet Res. - The role of social media in online weight management: systematic review. ( 0,766295178666006 )
BMC Med Inform Decis Mak - Criteria for assessing high-priority drug-drug interactions for clinical decision support in electronic health records. ( 0,764415308650935 )
J Telemed Telecare - A review of telemedicine interventions in diabetes care. ( 0,763947329454366 )
J Telemed Telecare - Physicians' perceptions of clinical supervision and educational support via videoconference: a systematic review. ( 0,759232421596724 )
J Biomed Inform - Recommendations for research design and reporting in computer-assisted diagnosis to facilitate meta-analysis. ( 0,757792351468263 )
Telemed J E Health - A systematic review of the evidence base for telehospice. ( 0,757251576966735 )
J Am Med Inform Assoc - Design-phase prediction of potential cancer clinical trial accrual success using a research data mart. ( 0,757041104642375 )
BMC Med Inform Decis Mak - Deficiencies in the transfer and availability of clinical trials evidence: a review of existing systems and standards. ( 0,756297140022555 )
Res Synth Methods - Use of indirect comparison methods in systematic reviews: a survey of Cochrane review authors. ( 0,755643084062621 )
Res Synth Methods - Quality assessment of comparative diagnostic accuracy studies: our experience using a modified version of the QUADAS-2 tool. ( 0,754628490701218 )
Int J Med Robot - Robotically assisted coronary artery bypass grafting: a systematic review and meta-analysis. ( 0,753967962242185 )
J Telemed Telecare - Telerehabilitation in stroke care--a systematic review. ( 0,753637890450826 )
Health Info Libr J - An evaluation of searching the German CCMed database for the production of systematic reviews. ( 0,753334348102968 )
J Telemed Telecare - A systematic review of the mediating role of knowledge, self-efficacy and self-care behaviour in telehealth patients with heart failure. ( 0,749494365702055 )
J Am Med Inform Assoc - Effects of computer-aided clinical decision support systems in improving antibiotic prescribing by primary care providers: a systematic review. ( 0,746725227089011 )
Res Synth Methods - Development of a combined database for meta-epidemiological research. ( 0,743165966735567 )
J Telemed Telecare - Costs and financial benefits of video communication compared to usual care at home: a systematic review. ( 0,741967949154367 )
Res Synth Methods - Searching for grey literature for systematic reviews: challenges and benefits. ( 0,741934514127145 )
Res Synth Methods - Evidence synthesis, economics and public policy. ( 0,735999662715436 )
J. Med. Internet Res. - Social network sites as a mode to collect health data: a systematic review. ( 0,735397834113247 )
Med Decis Making - Sponsorship-related outcome selection bias in published economic studies of triptans: systematic review. ( 0,733725709748746 )
BMC Med Inform Decis Mak - In pursuit of certainty: can the systematic review process deliver? ( 0,732643895452521 )
J. Med. Internet Res. - The use of social networking sites for public health practice and research: a systematic review. ( 0,731333420011444 )
Res Synth Methods - Quality assessment of qualitative evidence for systematic review and synthesis: Is it meaningful, and if so, how should it be performed? ( 0,730740105793847 )
J. Med. Internet Res. - A review of online evidence-based practice point-of-care information summary providers. ( 0,729794712334511 )
J. Med. Internet Res. - Wikis and collaborative writing applications in health care: a scoping review. ( 0,728758116183724 )
Health Info Libr J - Comparison of search strategies in systematic reviews of adverse effects to other systematic reviews. ( 0,728130526633716 )
J Telemed Telecare - Not all systematic reviews are systematic: a meta-review of the quality of systematic reviews for non-invasive remote monitoring in heart failure. ( 0,725782702510905 )
Res Synth Methods - Using logic models to capture complexity in systematic reviews. ( 0,725028284564598 )
Res Synth Methods - Opportunities and challenges in using studies without a control group in comparative effectiveness reviews. ( 0,724890328743923 )
Int J Med Inform - Impacts of structuring the electronic health record: a systematic review protocol and results of previous reviews. ( 0,722996070660275 )
Health Info Libr J - Implementation of Web 2.0 services in academic, medical and research libraries: a scoping review. ( 0,719080090702547 )
Int J Med Inform - Reviewing the impact of computerized provider order entry on clinical outcomes: The quality of systematic reviews. ( 0,718373823303054 )
J Telemed Telecare - Therapeutic videoconferencing interventions for the treatment of long-term conditions. ( 0,718231340852001 )
Med Decis Making - Statistical methods for cost-effectiveness analyses that use data from cluster randomized trials: a systematic review and checklist for critical appraisal. ( 0,71632862490431 )
Int J Med Inform - Framing the evidence for health smart homes and home-based consumer health technologies as a public health intervention for independent aging: a systematic review. ( 0,715715057595155 )
Int J Med Inform - Organizational issues in the implementation and adoption of health information technology innovations: an interpretative review. ( 0,713481908994899 )
BMC Med Inform Decis Mak - Many miles to go ?: a systematic review of the implementation of patient decision support interventions into routine clinical practice. ( 0,709469297555045 )
J. Med. Internet Res. - Effectiveness of web-based interventions on patient empowerment: a systematic review and meta-analysis. ( 0,708346059236458 )
BMC Med Inform Decis Mak - A systematic review of the implementation and impact of asthma protocols. ( 0,706378065333621 )
Int J Med Inform - Web-based interventions for the management of type 2 diabetes mellitus: a systematic review of recent evidence. ( 0,705813599494199 )
Health Info Libr J - What is the evidence that poster presentations are effective in promoting knowledge transfer? A state of the art review. ( 0,705059110002423 )
Med Decis Making - Bridging health technology assessment (HTA) and efficient health care decision making with multicriteria decision analysis (MCDA): applying the EVIDEM framework to medicines appraisal. ( 0,702935593711316 )
Int J Med Inform - Dashboards for improving patient care: review of the literature. ( 0,693809060612382 )
J Telemed Telecare - The status of telerehabilitation in neurological applications. ( 0,690437993914981 )
Telemed J E Health - Three principles for determining the relevancy of store-and-forward and live interactive telemedicine: reinterpreting two telemedicine research reviews and other research. ( 0,689293140037963 )
J Am Med Inform Assoc - Using the time and motion method to study clinical work processes and workflow: methodological inconsistencies and a call for standardized research. ( 0,686125823959795 )
J Am Med Inform Assoc - Scientific research in the age of omics: the good, the bad, and the sloppy. ( 0,685269249600482 )
J Telemed Telecare - Use of telephone and SMS reminders to improve attendance at hospital appointments: a systematic review. ( 0,684882266958717 )
J. Med. Internet Res. - An easily accessible Web-based minimization random allocation system for clinical trials. ( 0,683248855593971 )
J Telemed Telecare - A review of telerehabilitation for cardiac patients. ( 0,682491416882336 )
Int J Med Inform - The impact of medical informatics on patient satisfaction: a USA-based literature review. ( 0,679718513543738 )
BMC Med Inform Decis Mak - Systematic review of clinical decision support interventions with potential for inpatient cost reduction. ( 0,67855628239488 )
J Biomed Inform - A human-computer collaborative approach to identifying common data elements in clinical trial eligibility criteria. ( 0,676018647104861 )
J Telemed Telecare - Policy expectations and reality of telemedicine - a critical analysis of health care outcomes, costs and acceptance for congestive heart failure. ( 0,672941169208817 )
Health Informatics J - The use of weblogs within palliative care: a systematic literature review. ( 0,670608379970165 )
Res Synth Methods - Handsearching did not yield additional unique FDG-PET diagnostic test accuracy studies compared with electronic searches: a preliminary investigation. ( 0,670501347084617 )
Res Synth Methods - Techniques for identifying cross-disciplinary and 'hard-to-detect' evidence for systematic review. ( 0,668083141147323 )
J Telemed Telecare - A critical review of the use of telephone tests to identify cognitive impairment in epidemiology and clinical research. ( 0,667381651142357 )
BMC Med Inform Decis Mak - Risks to patient safety associated with implementation of electronic applications for medication management in ambulatory care--a systematic review. ( 0,666684791345778 )