J Biomed Inform - CPAS: a trans-omics pathway analysis tool for jointly analyzing DNA copy number variations and mRNA expression profiles data.

Tópicos

{ gene(2352) biolog(1181) express(1162) }
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{ method(2212) result(1239) propos(1039) }
{ detect(2391) sensit(1101) algorithm(908) }

Resumo

Pathway-based analysis approaches provide additional insights into the pathogenesis of complex diseases. Copy number variations (CNVs) play an important role in gene expression regulation. Joint pathway analysis of CNVs and gene expression data should provide more useful information for revealing the molecular mechanism of complex diseases. To implement trans-omics pathway analysis of genome-wide CNVs and mRNA expression profiles data, we extended the gene set enrichment analysis algorithm and developed a flexible trans-omics pathway analysis tool CPAS. CPAS was developed by C to interface with R for efficient data analysis. CNV-gene and pathway-gene annotation files derived from public database were included in CPAS. We hope that CPAS could help to identify disease-relevant biological pathways that were undetectable using traditional single-omic analysis approaches.

Resumo Limpo

pathwaybas analysi approach provid addit insight pathogenesi complex diseas copi number variat cnvs play import role gene express regul joint pathway analysi cnvs gene express data provid use inform reveal molecular mechan complex diseas implement transom pathway analysi genomewid cnvs mrna express profil data extend gene set enrich analysi algorithm develop flexibl transom pathway analysi tool cpas cpas develop c interfac r effici data analysi cnvgene pathwaygen annot file deriv public databas includ cpas hope cpas help identifi diseaserelev biolog pathway undetect use tradit singleom analysi approach

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