J Biomed Inform - The detection of risk pathways, regulated by miRNAs, via the integration of sample-matched miRNA-mRNA profiles and pathway structure.

Tópicos

{ gene(2352) biolog(1181) express(1162) }
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Resumo

The use of genome-wide, sample-matched miRNA (miRNAs)-mRNA expression data provides a powerful tool for the investigation of miRNAs and genes involved in diseases. The identification of miRNA-regulated pathways has been crucial for analysis of the role of miRNAs. However, the classical identification method fails to consider the structural information of pathways and the regulation of miRNAs simultaneously. We proposed a method that simultaneously integrated the change in gene expression and structural information in order to identify pathways. Our method used fold changes in miRNAs and gene products, along with the quantification of the regulatory effect on target genes, to measure the change in gene expression. Topological characteristics were investigated to measure the influence of gene products on entire pathways. Through the analysis of multiple myeloma and prostate cancer expression data, our method was proven to be effective and reliable in identifying disease risk pathways that are regulated by miRNAs. Further analysis showed that the structure of a pathway plays a crucial role in the recognition of the pathway as a factor in disease risk.

Resumo Limpo

use genomewid samplematch mirna mirnasmrna express data provid power tool investig mirna gene involv diseas identif mirnaregul pathway crucial analysi role mirna howev classic identif method fail consid structur inform pathway regul mirna simultan propos method simultan integr chang gene express structur inform order identifi pathway method use fold chang mirna gene product along quantif regulatori effect target gene measur chang gene express topolog characterist investig measur influenc gene product entir pathway analysi multipl myeloma prostat cancer express data method proven effect reliabl identifi diseas risk pathway regul mirna analysi show structur pathway play crucial role recognit pathway factor diseas risk

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