J Biomed Inform - Clustering clinical trials with similar eligibility criteria features.

Tópicos

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Resumo

JECTIVES: To automatically identify and cluster clinical trials with similar eligibility features.METHODS: Using the public repository ClinicalTrials.gov as the data source, we extracted semantic features from the eligibility criteria text of all clinical trials and constructed a trial-feature matrix. We calculated the pairwise similarities for all clinical trials based on their eligibility features. For all trials, by selecting one trial as the center each time, we identified trials whose similarities to the central trial were greater than or equal to a predefined threshold and constructed center-based clusters. Then we identified unique trial sets with distinctive trial membership compositions from center-based clusters by disregarding their structural information.RESULTS: From the 145,745 clinical trials on ClinicalTrials.gov, we extracted 5,508,491 semantic features. Of these, 459,936 were unique and 160,951 were shared by at least one pair of trials. Crowdsourcing the cluster evaluation using Amazon Mechanical Turk (MTurk), we identified the optimal similarity threshold, 0.9. Using this threshold, we generated 8806 center-based clusters. Evaluation of a sample of the clusters by MTurk resulted in a mean score 4.331?0.796 on a scale of 1-5 (5 indicating "strongly agree that the trials in the cluster are similar").CONCLUSIONS: We contribute an automated approach to clustering clinical trials with similar eligibility features. This approach can be potentially useful for investigating knowledge reuse patterns in clinical trial eligibility criteria designs and for improving clinical trial recruitment. We also contribute an effective crowdsourcing method for evaluating informatics interventions.

Resumo Limpo

jectiv automat identifi cluster clinic trial similar elig featuresmethod use public repositori clinicaltrialsgov data sourc extract semant featur elig criteria text clinic trial construct trialfeatur matrix calcul pairwis similar clinic trial base elig featur trial select one trial center time identifi trial whose similar central trial greater equal predefin threshold construct centerbas cluster identifi uniqu trial set distinct trial membership composit centerbas cluster disregard structur informationresult clinic trial clinicaltrialsgov extract semant featur uniqu share least one pair trial crowdsourc cluster evalu use amazon mechan turk mturk identifi optim similar threshold use threshold generat centerbas cluster evalu sampl cluster mturk result mean score scale indic strong agre trial cluster similarconclus contribut autom approach cluster clinic trial similar elig featur approach can potenti use investig knowledg reus pattern clinic trial elig criteria design improv clinic trial recruit also contribut effect crowdsourc method evalu informat intervent

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