J Biomed Inform - OnWARD: ontology-driven web-based framework for multi-center clinical studies.

Tópicos

{ data(3963) clinic(1234) research(1004) }
{ data(1714) softwar(1251) tool(1186) }
{ implement(1333) system(1263) develop(1122) }
{ studi(2440) review(1878) systemat(933) }
{ extract(1171) text(1153) clinic(932) }
{ imag(2830) propos(1344) filter(1198) }
{ system(1976) rule(880) can(841) }
{ error(1145) method(1030) estim(1020) }
{ method(1557) propos(1049) approach(1037) }
{ howev(809) still(633) remain(590) }
{ data(1737) use(1416) pattern(1282) }
{ framework(1458) process(801) describ(734) }
{ compound(1573) activ(1297) structur(1058) }
{ first(2504) two(1366) second(1323) }
{ can(981) present(881) function(850) }
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{ patient(2837) hospit(1953) medic(668) }
{ model(2656) set(1616) predict(1553) }
{ age(1611) year(1155) adult(843) }
{ medic(1828) order(1363) alert(1069) }
{ signal(2180) analysi(812) frequenc(800) }
{ group(2977) signific(1463) compar(1072) }
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{ detect(2391) sensit(1101) algorithm(908) }

Resumo

With a large percentage of clinical trials still using paper forms as the primary data collection tool, there is much potential for increasing efficiency through web-based data collection systems, especially for large-scale multi-center trials. This paper presents OnWARD, an ontology-driven, secure, rapidly-deployed, web-based framework supporting data capture for large-scale multi-center clinical research. Our approach is developed using the agile methodology to provide a flexible, user-centered dynamic form generator, which can be quickly deployed and customized for any clinical study without the need of deep technical expertise. Because of the flexible framework, the data management system can be extended to accommodate a large variety of data types, including genetic, genomic and proteomic data. In this paper, we demonstrate the initial deployment of OnWARD for a Phase II multi-center clinical trial after a development period of merely three months. The study utilizes 23 clinical report forms containing more than 1500 data points. Preliminary evaluation results show that OnWARD exceeded expectations of the clinical investigators in efficiency, flexibility and ease in setting up.

Resumo Limpo

larg percentag clinic trial still use paper form primari data collect tool much potenti increas effici webbas data collect system especi largescal multicent trial paper present onward ontologydriven secur rapidlydeploy webbas framework support data captur largescal multicent clinic research approach develop use agil methodolog provid flexibl usercent dynam form generat can quick deploy custom clinic studi without need deep technic expertis flexibl framework data manag system can extend accommod larg varieti data type includ genet genom proteom data paper demonstr initi deploy onward phase ii multicent clinic trial develop period mere three month studi util clinic report form contain data point preliminari evalu result show onward exceed expect clinic investig effici flexibl eas set

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