J Biomed Inform - Analysis of functional and pathway association of differential co-expressed genes: a case study in drug addiction.

Tópicos

{ gene(2352) biolog(1181) express(1162) }
{ drug(1928) target(777) effect(648) }
{ patient(2315) diseas(1263) diabet(1191) }
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Resumo

Drug addiction has been considered as a kind of chronic relapsing brain disease influenced by both genetic and environmental factors. At present, many causative genes and pathways related to diverse kinds of drug addiction have been discovered, while less attention has been paid to common mechanisms shared by different drugs underlying addiction. By applying a co-expression meta-analysis method to mRNA expression profiles of alcohol, cocaine, heroin addicted and normal samples, we identified significant gene co-expression pairs. As co-expression networks of drug group and control group constructed, associated function term pairs and pathway pairs reflected by co-expression pattern changes were discovered by integrating functional and pathway information respectively. The results indicated that respiratory electron transport chain, synaptic transmission, mitochondrial electron transport, signal transduction, locomotory behavior, response to amphetamine, negative regulation of cell migration, glucose regulation of insulin secretion, signaling by NGF, diabetes pathways, integration of energy metabolism, dopamine receptors may play an important role in drug addiction. In addition, the results can provide theory support for studies of addiction mechanisms.

Resumo Limpo

drug addict consid kind chronic relaps brain diseas influenc genet environment factor present mani causat gene pathway relat divers kind drug addict discov less attent paid common mechan share differ drug under addict appli coexpress metaanalysi method mrna express profil alcohol cocain heroin addict normal sampl identifi signific gene coexpress pair coexpress network drug group control group construct associ function term pair pathway pair reflect coexpress pattern chang discov integr function pathway inform respect result indic respiratori electron transport chain synapt transmiss mitochondri electron transport signal transduct locomotori behavior respons amphetamin negat regul cell migrat glucos regul insulin secret signal ngf diabet pathway integr energi metabol dopamin receptor may play import role drug addict addit result can provid theori support studi addict mechan

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