Artif Intell Med - Feasibility of case-based beam generation for robotic radiosurgery.

Tópicos

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Resumo

JECTIVE: Robotic radiosurgery uses the kinematic flexibility of a robotic arm to target tumors and lesions from many different directions. This approach allows to focus the dose to the target region while sparing healthy surrounding tissue. However, the flexibility in the placement of treatment beams is also a challenge during treatment planning. We study an approach to make the search for treatment beams more efficient by considering previous treatment plans.METHODS AND MATERIAL: Conventionally, a beam generation heuristic based on randomly selected candidate beams has been proven to be most robust in clinical practice. However, for prevalent types of cancer similarities in patient anatomy and dose prescription exist. We present a case-based approach that introduces a problem specific measure of similarity and allows to generate candidate beams from a database of previous treatment plans. Similarity between treatments is established based on projections of the organs and structures considered during planning, and the desired dose distribution. Solving the inverse planning problem a subset of treatment beams is determined and adapted to the new clinical case.RESULTS: Preliminary experimental results indicate that the new approach leads to comparable plan quality for substantially fewer candidate beams. For two prostate cases, the dose homogeneity in the target region and the sparing of critical structures is similar for plans based on 400 and 600 candidate beams generated with the novel and the conventional method, respectively. However, the runtime for solving the inverse planning problem for could be reduced by up to 47%, i.e., from approximately 19 min to less than 11 min.CONCLUSION: We have shown the feasibility of case-based beam generation for robotic radiosurgery. For prevalent clinical cases with similar anatomy the cased-based approach could substantially reduce planning time while maintaining high plan quality.

Resumo Limpo

jectiv robot radiosurgeri use kinemat flexibl robot arm target tumor lesion mani differ direct approach allow focus dose target region spare healthi surround tissu howev flexibl placement treatment beam also challeng treatment plan studi approach make search treatment beam effici consid previous treatment plansmethod materi convent beam generat heurist base random select candid beam proven robust clinic practic howev preval type cancer similar patient anatomi dose prescript exist present casebas approach introduc problem specif measur similar allow generat candid beam databas previous treatment plan similar treatment establish base project organ structur consid plan desir dose distribut solv invers plan problem subset treatment beam determin adapt new clinic caseresult preliminari experiment result indic new approach lead compar plan qualiti substanti fewer candid beam two prostat case dose homogen target region spare critic structur similar plan base candid beam generat novel convent method respect howev runtim solv invers plan problem reduc ie approxim min less minconclus shown feasibl casebas beam generat robot radiosurgeri preval clinic case similar anatomi casedbas approach substanti reduc plan time maintain high plan qualiti

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