J Biomed Inform - Integrating reasoning and clinical archetypes using OWL ontologies and SWRL rules.

Tópicos

{ concept(1167) ontolog(924) domain(897) }
{ clinic(1479) use(1117) guidelin(835) }
{ framework(1458) process(801) describ(734) }
{ system(1976) rule(880) can(841) }
{ perform(1367) use(1326) method(1137) }
{ general(901) number(790) one(736) }
{ record(1888) medic(1808) patient(1693) }
{ medic(1828) order(1363) alert(1069) }
{ care(1570) inform(1187) nurs(1089) }
{ search(2224) databas(1162) retriev(909) }
{ system(1050) medic(1026) inform(1018) }
{ spatial(1525) area(1432) region(1030) }
{ data(2317) use(1299) case(1017) }
{ data(3008) multipl(1320) sourc(1022) }
{ health(1844) social(1437) communiti(874) }
{ decis(3086) make(1611) patient(1517) }
{ process(1125) use(805) approach(778) }
{ data(1737) use(1416) pattern(1282) }
{ measur(2081) correl(1212) valu(896) }
{ bind(1733) structur(1185) ligand(1036) }
{ sequenc(1873) structur(1644) protein(1328) }
{ network(2748) neural(1063) input(814) }
{ surgeri(1148) surgic(1085) robot(1054) }
{ data(1714) softwar(1251) tool(1186) }
{ control(1307) perform(991) simul(935) }
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{ howev(809) still(633) remain(590) }
{ research(1085) discuss(1038) issu(1018) }
{ ehr(2073) health(1662) electron(1139) }
{ cost(1906) reduc(1198) effect(832) }
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{ time(1939) patient(1703) rate(768) }
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{ patient(2837) hospit(1953) medic(668) }
{ model(2656) set(1616) predict(1553) }
{ age(1611) year(1155) adult(843) }
{ signal(2180) analysi(812) frequenc(800) }
{ group(2977) signific(1463) compar(1072) }
{ sampl(1606) size(1419) use(1276) }
{ gene(2352) biolog(1181) express(1162) }
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{ use(1733) differ(960) four(931) }
{ drug(1928) target(777) effect(648) }
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{ implement(1333) system(1263) develop(1122) }
{ survey(1388) particip(1329) question(1065) }
{ activ(1452) weight(1219) physic(1104) }
{ method(1969) cluster(1462) data(1082) }
{ method(2212) result(1239) propos(1039) }
{ detect(2391) sensit(1101) algorithm(908) }

Resumo

Semantic interoperability is essential to facilitate the computerized support for alerts, workflow management and evidence-based healthcare across heterogeneous electronic health record (EHR) systems. Clinical archetypes, which are formal definitions of specific clinical concepts defined as specializations of a generic reference (information) model, provide a mechanism to express data structures in a shared and interoperable way. However, currently available archetype languages do not provide direct support for mapping to formal ontologies and then exploiting reasoning on clinical knowledge, which are key ingredients of full semantic interoperability, as stated in the SemanticHEALTH report [1]. This paper reports on an approach to translate definitions expressed in the openEHR Archetype Definition Language (ADL) to a formal representation expressed using the Ontology Web Language (OWL). The formal representations are then integrated with rules expressed with Semantic Web Rule Language (SWRL) expressions, providing an approach to apply the SWRL rules to concrete instances of clinical data. Sharing the knowledge expressed in the form of rules is consistent with the philosophy of open sharing, encouraged by archetypes. Our approach also allows the reuse of formal knowledge, expressed through ontologies, and extends reuse to propositions of declarative knowledge, such as those encoded in clinical guidelines. This paper describes the ADL-to-OWL translation approach, describes the techniques to map archetypes to formal ontologies, and demonstrates how rules can be applied to the resulting representation. We provide examples taken from a patient safety alerting system to illustrate our approach.

Resumo Limpo

semant interoper essenti facilit computer support alert workflow manag evidencebas healthcar across heterogen electron health record ehr system clinic archetyp formal definit specif clinic concept defin special generic refer inform model provid mechan express data structur share interoper way howev current avail archetyp languag provid direct support map formal ontolog exploit reason clinic knowledg key ingredi full semant interoper state semantichealth report paper report approach translat definit express openehr archetyp definit languag adl formal represent express use ontolog web languag owl formal represent integr rule express semant web rule languag swrl express provid approach appli swrl rule concret instanc clinic data share knowledg express form rule consist philosophi open share encourag archetyp approach also allow reus formal knowledg express ontolog extend reus proposit declar knowledg encod clinic guidelin paper describ adltoowl translat approach describ techniqu map archetyp formal ontolog demonstr rule can appli result represent provid exampl taken patient safeti alert system illustr approach

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