J Biomed Inform - Towards an ontological theory of substance intolerance and hypersensitivity.

Tópicos

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Resumo

A proper ontological treatment of intolerance--including hypersensitivity--to various substances is critical to patient care and research. However, existing methods and standards for documenting these conditions have flaws that inhibit these goals, especially translational research that bridges the two activities. In response, I outline a realist approach to the ontology of substance intolerance, including hypersensitivity conditions. I defend a view of these conditions as a subtype of disease. Specifically, a substance intolerance is a disease whose pathological process(es) are realized upon exposure to a quantity of substance of a particular type, and this quantity would normally not cause the realization of the pathological process(es). To develop this theory, it was necessary to build pieces of a theory of pathological processes. Overall, however, the framework of the Ontology for General Medical Science (which uses Basic Formal Ontology as its uppermost level) was a more-than-adequate foundation on which to build the theory.

Resumo Limpo

proper ontolog treatment intoleranceinclud hypersensitivityto various substanc critic patient care research howev exist method standard document condit flaw inhibit goal especi translat research bridg two activ respons outlin realist approach ontolog substanc intoler includ hypersensit condit defend view condit subtyp diseas specif substanc intoler diseas whose patholog process realiz upon exposur quantiti substanc particular type quantiti normal caus realiz patholog process develop theori necessari build piec theori patholog process overal howev framework ontolog general medic scienc use basic formal ontolog uppermost level morethanadequ foundat build theori

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