J Chem Inf Model - In silico prediction of chemical Ames mutagenicity.

Tópicos

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Resumo

Mutagenicity is one of the most important end points of toxicity. Due to high cost and laboriousness in experimental tests, it is necessary to develop robust in silico methods to predict chemical mutagenicity. In this paper, a comprehensive database containing 7617 diverse compounds, including 4252 mutagens and 3365 nonmutagens, was constructed. On the basis of this data set, high predictive models were then built using five machine learning methods, namely support vector machine (SVM), C4.5 decision tree (C4.5 DT), artificial neural network (ANN), k-nearest neighbors (kNN), and na?ve Bayes (NB), along with five fingerprints, namely CDK fingerprint (FP), Estate fingerprint (Estate), MACCS keys (MACCS), PubChem fingerprint (PubChem), and Substructure fingerprint (SubFP). Performances were measured by cross validation and an external test set containing 831 diverse chemicals. Information gain and substructure analysis were used to interpret the models. The accuracies of fivefold cross validation were from 0.808 to 0.841 for top five models. The range of accuracy for the external validation set was from 0.904 to 0.980, which outperformed that of Toxtree. Three models (PubChem-kNN, MACCS-kNN, and PubChem-SVM) showed high and reliable predictive accuracy for the mutagens and nonmutagens and, hence, could be used in prediction of chemical Ames mutagenicity.

Resumo Limpo

mutagen one import end point toxic due high cost labori experiment test necessari develop robust silico method predict chemic mutagen paper comprehens databas contain divers compound includ mutagen nonmutagen construct basi data set high predict model built use five machin learn method name support vector machin svm c decis tree c dt artifici neural network ann knearest neighbor knn nave bay nb along five fingerprint name cdk fingerprint fp estat fingerprint estat macc key macc pubchem fingerprint pubchem substructur fingerprint subfp perform measur cross valid extern test set contain divers chemic inform gain substructur analysi use interpret model accuraci fivefold cross valid top five model rang accuraci extern valid set outperform toxtre three model pubchemknn maccsknn pubchemsvm show high reliabl predict accuraci mutagen nonmutagen henc use predict chemic ame mutagen

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