Artif Intell Med - Natural occurrence of nocturnal hypoglycemia detection using hybrid particle swarm optimized fuzzy reasoning model.

Tópicos

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Resumo

TRODUCTION: Low blood glucose (hypoglycemia) is a common and serious side effect of insulin therapy in patients with diabetes. This paper will make a contribution to knowledge in the modeling and design of a non-invasive hypoglycemia monitor for patients with type 1 diabetes mellitus (T1DM) using a fuzzy-reasoning system.METHODS: Based on the heart rate and the corrected QT interval of the electrocardiogram (ECG) signal, we have developed a hybrid particle-swarm-optimization-based fuzzy-reasoning model to recognize the presence of hypoglycemic episodes. To optimize the fuzzy rules and the fuzzy-membership functions, a hybrid particle-swarm-optimization with wavelet mutation operation is investigated.RESULTS: From our clinical study of 16 children with T1DM, natural occurrence of nocturnal-hypoglycemic episodes was associated with increased heart rates and increased corrected QT intervals. All the data sets were collected from the Government of Western Australia's Department of Health. All data were organized randomly into a training set (8 patients with 320 data points) and a testing set (another 8 patients with 269 data points). To prevent the phenomenon of overtraining, we separated the training set into 2 sets (4 patients in each set) and a fitness function was introduced for this training process. The testing performances of the proposed algorithm for detection of advanced hypoglycemic episodes (sensitivity=85.71% and specificity=79.84%) and hypoglycemic episodes (sensitivity=80.00% and specificity=55.14%) were given.CONCLUSION: We have investigated the detection for the natural occurrence of nocturnal hypoglycemic episodes in T1DM using a hybrid particle-swarm-optimization-based fuzzy-reasoning model with physiological parameters. In this study, no restricted environment (e.g. patient's dietary requirements) is required. Furthermore, the sampling time is between 5 and 10 min. To conclude, we have shown that the testing performances of the proposed algorithm for detection of advanced hypoglycemic and hypoglycemic episodes for T1DM patients are satisfactory.

Resumo Limpo

troduct low blood glucos hypoglycemia common serious side effect insulin therapi patient diabet paper will make contribut knowledg model design noninvas hypoglycemia monitor patient type diabet mellitus tdm use fuzzyreason systemmethod base heart rate correct qt interv electrocardiogram ecg signal develop hybrid particleswarmoptimizationbas fuzzyreason model recogn presenc hypoglycem episod optim fuzzi rule fuzzymembership function hybrid particleswarmoptim wavelet mutat oper investigatedresult clinic studi children tdm natur occurr nocturnalhypoglycem episod associ increas heart rate increas correct qt interv data set collect govern western australia depart health data organ random train set patient data point test set anoth patient data point prevent phenomenon overtrain separ train set set patient set fit function introduc train process test perform propos algorithm detect advanc hypoglycem episod sensit specif hypoglycem episod sensit specif givenconclus investig detect natur occurr nocturn hypoglycem episod tdm use hybrid particleswarmoptimizationbas fuzzyreason model physiolog paramet studi restrict environ eg patient dietari requir requir furthermor sampl time min conclud shown test perform propos algorithm detect advanc hypoglycem hypoglycem episod tdm patient satisfactori

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