J Chem Inf Model - Atom environment kernels on molecules.

Tópicos

{ learn(2355) train(1041) set(1003) }
{ structur(1116) can(940) graph(676) }
{ measur(2081) correl(1212) valu(896) }
{ extract(1171) text(1153) clinic(932) }
{ sequenc(1873) structur(1644) protein(1328) }
{ method(1219) similar(1157) match(930) }
{ perform(1367) use(1326) method(1137) }
{ can(774) often(719) complex(702) }
{ bind(1733) structur(1185) ligand(1036) }
{ model(2341) predict(2261) use(1141) }
{ compound(1573) activ(1297) structur(1058) }
{ patient(1821) servic(1111) care(1106) }
{ model(3480) simul(1196) paramet(876) }
{ use(976) code(926) identifi(902) }
{ use(1733) differ(960) four(931) }
{ drug(1928) target(777) effect(648) }
{ system(1976) rule(880) can(841) }
{ featur(3375) classif(2383) classifi(1994) }
{ assess(1506) score(1403) qualiti(1306) }
{ control(1307) perform(991) simul(935) }
{ method(984) reconstruct(947) comput(926) }
{ featur(1941) imag(1645) propos(1176) }
{ howev(809) still(633) remain(590) }
{ data(3963) clinic(1234) research(1004) }
{ research(1085) discuss(1038) issu(1018) }
{ monitor(1329) mobil(1314) devic(1160) }
{ research(1218) medic(880) student(794) }
{ cost(1906) reduc(1198) effect(832) }
{ time(1939) patient(1703) rate(768) }
{ can(981) present(881) function(850) }
{ high(1669) rate(1365) level(1280) }
{ decis(3086) make(1611) patient(1517) }
{ activ(1452) weight(1219) physic(1104) }
{ method(1969) cluster(1462) data(1082) }
{ model(3404) distribut(989) bayesian(671) }
{ imag(1947) propos(1133) code(1026) }
{ data(1737) use(1416) pattern(1282) }
{ inform(2794) health(2639) internet(1427) }
{ imag(1057) registr(996) error(939) }
{ imag(2830) propos(1344) filter(1198) }
{ network(2748) neural(1063) input(814) }
{ imag(2675) segment(2577) method(1081) }
{ patient(2315) diseas(1263) diabet(1191) }
{ take(945) account(800) differ(722) }
{ studi(2440) review(1878) systemat(933) }
{ motion(1329) object(1292) video(1091) }
{ treatment(1704) effect(941) patient(846) }
{ surgeri(1148) surgic(1085) robot(1054) }
{ framework(1458) process(801) describ(734) }
{ problem(2511) optim(1539) algorithm(950) }
{ error(1145) method(1030) estim(1020) }
{ chang(1828) time(1643) increas(1301) }
{ concept(1167) ontolog(924) domain(897) }
{ clinic(1479) use(1117) guidelin(835) }
{ algorithm(1844) comput(1787) effici(935) }
{ method(1557) propos(1049) approach(1037) }
{ data(1714) softwar(1251) tool(1186) }
{ design(1359) user(1324) use(1319) }
{ model(2220) cell(1177) simul(1124) }
{ care(1570) inform(1187) nurs(1089) }
{ general(901) number(790) one(736) }
{ search(2224) databas(1162) retriev(909) }
{ case(1353) use(1143) diagnosi(1136) }
{ studi(1410) differ(1259) use(1210) }
{ risk(3053) factor(974) diseas(938) }
{ perform(999) metric(946) measur(919) }
{ system(1050) medic(1026) inform(1018) }
{ import(1318) role(1303) understand(862) }
{ visual(1396) interact(850) tool(830) }
{ studi(1119) effect(1106) posit(819) }
{ blood(1257) pressur(1144) flow(957) }
{ spatial(1525) area(1432) region(1030) }
{ record(1888) medic(1808) patient(1693) }
{ health(3367) inform(1360) care(1135) }
{ ehr(2073) health(1662) electron(1139) }
{ state(1844) use(1261) util(961) }
{ patient(2837) hospit(1953) medic(668) }
{ model(2656) set(1616) predict(1553) }
{ data(2317) use(1299) case(1017) }
{ age(1611) year(1155) adult(843) }
{ medic(1828) order(1363) alert(1069) }
{ signal(2180) analysi(812) frequenc(800) }
{ group(2977) signific(1463) compar(1072) }
{ sampl(1606) size(1419) use(1276) }
{ gene(2352) biolog(1181) express(1162) }
{ data(3008) multipl(1320) sourc(1022) }
{ first(2504) two(1366) second(1323) }
{ intervent(3218) particip(2042) group(1664) }
{ activ(1138) subject(705) human(624) }
{ use(2086) technolog(871) perceiv(783) }
{ analysi(2126) use(1163) compon(1037) }
{ health(1844) social(1437) communiti(874) }
{ cancer(2502) breast(956) screen(824) }
{ result(1111) use(1088) new(759) }
{ implement(1333) system(1263) develop(1122) }
{ survey(1388) particip(1329) question(1065) }
{ estim(2440) model(1874) function(577) }
{ process(1125) use(805) approach(778) }
{ method(2212) result(1239) propos(1039) }
{ detect(2391) sensit(1101) algorithm(908) }

Resumo

The measurement of molecular similarity is an essential part of various machine learning tasks in chemical informatics. Graph kernels provide good similarity measures between molecules. Conventional graph kernels are based on counting common subgraphs of specific types in the molecular graphs. This approach has two primary limitations: (i) only exact subgraph matching is considered in the counting operation, and (ii) most of the subgraphs will be less relevant to a given task. In order to address the above-mentioned limitations, we propose a new graph kernel as an extension of the subtree kernel initially proposed by Ramon and G?rtner (2003). The proposed kernel tolerates an inexact match between subgraphs by allowing matching between atoms with similar local environments. In addition, the proposed kernel provides a method to assign an importance weight to each subgraph according to the relevance to the task, which is predetermined by a statistical test. These extensions are evaluated for classification and regression tasks of predicting a wide range of pharmaceutical properties from molecular structures, with promising results.

Resumo Limpo

measur molecular similar essenti part various machin learn task chemic informat graph kernel provid good similar measur molecul convent graph kernel base count common subgraph specif type molecular graph approach two primari limit exact subgraph match consid count oper ii subgraph will less relev given task order address abovement limit propos new graph kernel extens subtre kernel initi propos ramon grtner propos kernel toler inexact match subgraph allow match atom similar local environ addit propos kernel provid method assign import weight subgraph accord relev task predetermin statist test extens evalu classif regress task predict wide rang pharmaceut properti molecular structur promis result

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