Artif Intell Med - An automated diagnostic system of polycystic ovary syndrome based on object growing.


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JECTIVE: Polycystic ovary syndrome (PCOS) is a complex endocrine disorder that seriously affects women's health. The disorder is characterized by the formation of many follicles in the ovary. Currently the predominant diagnosis is to manually count the number of follicles, which may lead to inter-observer and intra-observer variability and low efficiency. A computer-aided PCOS diagnostic system may overcome these problems. However the methods reported in recently published literature are not very effective and often need human interaction. To overcome these problems, we propose an automated PCOS diagnostic system based on ultrasound images.METHODS AND MATERIALS: The proposed system consists of two major functional blocks: preprocessing phase and follicle identification based on object growing. In the preprocessing phase, speckle noise in the input image is removed by an adaptive morphological filter, then contours of objects are extracted using an enhanced labeled watershed algorithm, and finally the region of interest is automatically selected. The object growing algorithm for follicle identification first computes a cost map to distinguish between the ovary and its external region and assigns each object a cost function based on the cost map. The object growing algorithm initially selects several objects that are likely to be follicles with very high probabilities and dynamically update the set of possible follicles based on their cost functions. The proposed method was applied to 31 real PCOS ultrasound images obtained from patients and its performance was compared with those of three other methods, including level set method, boundary vector field (BVF) method and the fuzzy support vector machine (FSVM) classifier.RESULTS: Based on the judgment of subject matter experts, the proposed diagnostic system achieved 89.4% recognition rate (RR) and 7.45% misidentification rate (MR) while the RR and MR of the level set method, the BVF method and the FSVM classifier are around 65.3% and 2.11%, 76.1% and 4.53%, and 84.0% and 16.3%, respectively. The proposed diagnostic system also achieved better performance than those reported in recently published literature.CONCLUSION: The paper proposed an automated diagnostic system for the PCOS using ultrasound images, which consists of two major functional blocks: preprocessing phase and follicle identification based on object growing. Experimental results showed that the proposed system is very effective in follicle identification for PCOS diagnosis.

Resumo Limpo

jectiv polycyst ovari syndrom pcos complex endocrin disord serious affect women health disord character format mani follicl ovari current predomin diagnosi manual count number follicl may lead interobserv intraobserv variabl low effici computeraid pcos diagnost system may overcom problem howev method report recent publish literatur effect often need human interact overcom problem propos autom pcos diagnost system base ultrasound imagesmethod materi propos system consist two major function block preprocess phase follicl identif base object grow preprocess phase speckl nois input imag remov adapt morpholog filter contour object extract use enhanc label watersh algorithm final region interest automat select object grow algorithm follicl identif first comput cost map distinguish ovari extern region assign object cost function base cost map object grow algorithm initi select sever object like follicl high probabl dynam updat set possibl follicl base cost function propos method appli real pcos ultrasound imag obtain patient perform compar three method includ level set method boundari vector field bvf method fuzzi support vector machin fsvm classifierresult base judgment subject matter expert propos diagnost system achiev recognit rate rr misidentif rate mr rr mr level set method bvf method fsvm classifi around respect propos diagnost system also achiev better perform report recent publish literatureconclus paper propos autom diagnost system pcos use ultrasound imag consist two major function block preprocess phase follicl identif base object grow experiment result show propos system effect follicl identif pcos diagnosi

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