Artif Intell Med - An ontology-based comparative anatomy information system.

Tópicos

{ method(1219) similar(1157) match(930) }
{ design(1359) user(1324) use(1319) }
{ model(2220) cell(1177) simul(1124) }
{ monitor(1329) mobil(1314) devic(1160) }
{ concept(1167) ontolog(924) domain(897) }
{ visual(1396) interact(850) tool(830) }
{ search(2224) databas(1162) retriev(909) }
{ bind(1733) structur(1185) ligand(1036) }
{ error(1145) method(1030) estim(1020) }
{ method(1557) propos(1049) approach(1037) }
{ medic(1828) order(1363) alert(1069) }
{ survey(1388) particip(1329) question(1065) }
{ decis(3086) make(1611) patient(1517) }
{ assess(1506) score(1403) qualiti(1306) }
{ research(1218) medic(880) student(794) }
{ cost(1906) reduc(1198) effect(832) }
{ system(1976) rule(880) can(841) }
{ framework(1458) process(801) describ(734) }
{ use(976) code(926) identifi(902) }
{ can(774) often(719) complex(702) }
{ sequenc(1873) structur(1644) protein(1328) }
{ general(901) number(790) one(736) }
{ system(1050) medic(1026) inform(1018) }
{ studi(1119) effect(1106) posit(819) }
{ record(1888) medic(1808) patient(1693) }
{ model(3480) simul(1196) paramet(876) }
{ high(1669) rate(1365) level(1280) }
{ activ(1452) weight(1219) physic(1104) }
{ imag(2830) propos(1344) filter(1198) }
{ studi(2440) review(1878) systemat(933) }
{ treatment(1704) effect(941) patient(846) }
{ problem(2511) optim(1539) algorithm(950) }
{ clinic(1479) use(1117) guidelin(835) }
{ extract(1171) text(1153) clinic(932) }
{ howev(809) still(633) remain(590) }
{ risk(3053) factor(974) diseas(938) }
{ import(1318) role(1303) understand(862) }
{ model(2341) predict(2261) use(1141) }
{ data(2317) use(1299) case(1017) }
{ age(1611) year(1155) adult(843) }
{ time(1939) patient(1703) rate(768) }
{ use(2086) technolog(871) perceiv(783) }
{ model(3404) distribut(989) bayesian(671) }
{ imag(1947) propos(1133) code(1026) }
{ data(1737) use(1416) pattern(1282) }
{ inform(2794) health(2639) internet(1427) }
{ measur(2081) correl(1212) valu(896) }
{ imag(1057) registr(996) error(939) }
{ featur(3375) classif(2383) classifi(1994) }
{ network(2748) neural(1063) input(814) }
{ imag(2675) segment(2577) method(1081) }
{ patient(2315) diseas(1263) diabet(1191) }
{ take(945) account(800) differ(722) }
{ motion(1329) object(1292) video(1091) }
{ surgeri(1148) surgic(1085) robot(1054) }
{ chang(1828) time(1643) increas(1301) }
{ learn(2355) train(1041) set(1003) }
{ algorithm(1844) comput(1787) effici(935) }
{ data(1714) softwar(1251) tool(1186) }
{ control(1307) perform(991) simul(935) }
{ care(1570) inform(1187) nurs(1089) }
{ method(984) reconstruct(947) comput(926) }
{ featur(1941) imag(1645) propos(1176) }
{ case(1353) use(1143) diagnosi(1136) }
{ data(3963) clinic(1234) research(1004) }
{ studi(1410) differ(1259) use(1210) }
{ perform(999) metric(946) measur(919) }
{ research(1085) discuss(1038) issu(1018) }
{ compound(1573) activ(1297) structur(1058) }
{ perform(1367) use(1326) method(1137) }
{ blood(1257) pressur(1144) flow(957) }
{ spatial(1525) area(1432) region(1030) }
{ health(3367) inform(1360) care(1135) }
{ ehr(2073) health(1662) electron(1139) }
{ state(1844) use(1261) util(961) }
{ patient(2837) hospit(1953) medic(668) }
{ model(2656) set(1616) predict(1553) }
{ signal(2180) analysi(812) frequenc(800) }
{ group(2977) signific(1463) compar(1072) }
{ sampl(1606) size(1419) use(1276) }
{ gene(2352) biolog(1181) express(1162) }
{ data(3008) multipl(1320) sourc(1022) }
{ first(2504) two(1366) second(1323) }
{ intervent(3218) particip(2042) group(1664) }
{ activ(1138) subject(705) human(624) }
{ patient(1821) servic(1111) care(1106) }
{ can(981) present(881) function(850) }
{ analysi(2126) use(1163) compon(1037) }
{ health(1844) social(1437) communiti(874) }
{ structur(1116) can(940) graph(676) }
{ cancer(2502) breast(956) screen(824) }
{ use(1733) differ(960) four(931) }
{ drug(1928) target(777) effect(648) }
{ result(1111) use(1088) new(759) }
{ implement(1333) system(1263) develop(1122) }
{ estim(2440) model(1874) function(577) }
{ process(1125) use(805) approach(778) }
{ method(1969) cluster(1462) data(1082) }
{ method(2212) result(1239) propos(1039) }
{ detect(2391) sensit(1101) algorithm(908) }

Resumo

TRODUCTION: This paper describes the design, implementation, and potential use of a comparative anatomy information system (CAIS) for querying on similarities and differences between homologous anatomical structures across species, the knowledge base it operates upon, the method it uses for determining the answers to the queries, and the user interface it employs to present the results. The relevant informatics contributions of our work include (1) the development and application of the structural difference method, a formalism for symbolically representing anatomical similarities and differences across species; (2) the design of the structure of a mapping between the anatomical models of two different species and its application to information about specific structures in humans, mice, and rats; and (3) the design of the internal syntax and semantics of the query language. These contributions provide the foundation for the development of a working system that allows users to submit queries about the similarities and differences between mouse, rat, and human anatomy; delivers result sets that describe those similarities and differences in symbolic terms; and serves as a prototype for the extension of the knowledge base to any number of species. Additionally, we expanded the domain knowledge by identifying medically relevant structural questions for the human, the mouse, and the rat, and made an initial foray into the validation of the application and its content by means of user questionnaires, software testing, and other feedback.METHODS: The anatomical structures of the species to be compared, as well as the mappings between species, are modeled on templates from the Foundational Model of Anatomy knowledge base, and compared using graph-matching techniques. A graphical user interface allows users to issue queries that retrieve information concerning similarities and differences between structures in the species being examined. Queries from diverse information sources, including domain experts, peer-reviewed articles, and reference books, have been used to test the system and to illustrate its potential use in comparative anatomy studies.RESULTS: 157 test queries were submitted to the CAIS system, and all of them were correctly answered. The interface was evaluated in terms of clarity and ease of use. This testing determined that the application works well, and is fairly intuitive to use, but users want to see more clarification of the meaning of the different types of possible queries. Some of the interface issues will naturally be resolved as we refine our conceptual model to deal with partial and complex homologies in the content.CONCLUSIONS: The CAIS system and its associated methods are expected to be useful to biologists and translational medicine researchers. Possible applications range from supporting theoretical work in clarifying and modeling ontogenetic, physiological, pathological, and evolutionary transformations, to concrete techniques for improving the analysis of genotype-phenotype relationships among various animal models in support of a wide array of clinical and scientific initiatives.

Resumo Limpo

troduct paper describ design implement potenti use compar anatomi inform system cai queri similar differ homolog anatom structur across speci knowledg base oper upon method use determin answer queri user interfac employ present result relev informat contribut work includ develop applic structur differ method formal symbol repres anatom similar differ across speci design structur map anatom model two differ speci applic inform specif structur human mice rat design intern syntax semant queri languag contribut provid foundat develop work system allow user submit queri similar differ mous rat human anatomi deliv result set describ similar differ symbol term serv prototyp extens knowledg base number speci addit expand domain knowledg identifi medic relev structur question human mous rat made initi foray valid applic content mean user questionnair softwar test feedbackmethod anatom structur speci compar well map speci model templat foundat model anatomi knowledg base compar use graphmatch techniqu graphic user interfac allow user issu queri retriev inform concern similar differ structur speci examin queri divers inform sourc includ domain expert peerreview articl refer book use test system illustr potenti use compar anatomi studiesresult test queri submit cai system correct answer interfac evalu term clariti eas use test determin applic work well fair intuit use user want see clarif mean differ type possibl queri interfac issu will natur resolv refin conceptu model deal partial complex homolog contentconclus cai system associ method expect use biologist translat medicin research possibl applic rang support theoret work clarifi model ontogenet physiolog patholog evolutionari transform concret techniqu improv analysi genotypephenotyp relationship among various anim model support wide array clinic scientif initi

Resumos Similares

Appl Clin Inform - The impact of domain knowledge on structured data collection and templated note design. ( 0,630167919839163 )
J Chem Inf Model - iBIOMES Lite: summarizing biomolecular simulation data in limited settings. ( 0,626481808579406 )
Int J Med Inform - Content analysis of physical examination templates in electronic health records using SNOMED CT. ( 0,612872424411523 )
Int J Comput Assist Radiol Surg - Web-based bone age assessment by content-based image retrieval for case-based reasoning. ( 0,58904668798669 )
Int J Comput Assist Radiol Surg - Multi-contrast unbiased MRI atlas of a Parkinson's disease population. ( 0,557939915992428 )
J Med Syst - RFID sensor-tags feeding a context-aware rule-based healthcare monitoring system. ( 0,550483253381143 )
J Med Syst - Virtual suturing simulation based on commodity physics engine for medical learning. ( 0,546589060910892 )
J Biomed Inform - vSPARQL: a view definition language for the semantic web. ( 0,540569664286057 )
J. Med. Internet Res. - Two complementary personal medication management applications developed on a common platform: case report. ( 0,539163400483728 )
J Chem Inf Model - Large-scale mining for similar protein binding pockets: with RAPMAD retrieval on the fly becomes real. ( 0,537265071933112 )
Methods Inf Med - Binding SNOMED CT terms to archetype elements. Establishing a baseline of results. ( 0,537176274018379 )
Artif Intell Med - Visually defining and querying consistent multi-granular clinical temporal abstractions. ( 0,527595860908944 )
IEEE J Biomed Health Inform - Histology image retrieval in optimised multi-feature spaces. ( 0,518737133326192 )
Appl Clin Inform - Methods and applications for visualization of SNOMED CT concept sets. ( 0,511299087911059 )
Int J Med Robot - Robotic system with sweeping palpation and needle biopsy for prostate cancer diagnosis. ( 0,505534719494066 )
Med Biol Eng Comput - Patient-specific finite element modeling of the Cardiokinetix Parachute(?) device: effects on left ventricular wall stress and function. ( 0,501734825534288 )
J Integr Bioinform - Data integration using scanners with SQL output--the bioscanners project at sourceforge. ( 0,500330906720537 )
Comput Methods Programs Biomed - BiOSS: A system for biomedical ontology selection. ( 0,498492797790825 )
Comput Methods Programs Biomed - An FDTD-based computer simulation platform for shock wave propagation in electrohydraulic lithotripsy. ( 0,497544113509468 )
BMC Med Inform Decis Mak - Improving access to clinical practice guidelines with an interactive graphical interface using an iconic language. ( 0,495656711893176 )
IEEE Trans Image Process - Correlation-coefficient-based fast template matching through partial elimination. ( 0,495334187160565 )
IEEE Trans Vis Comput Graph - Evaluation of Interactive Visualization on Mobile Computing Platforms for Selection of Deep Brain Stimulation Parameters. ( 0,494885440000717 )
J Chem Inf Model - Build-up algorithm for atomic correspondence between chemical structures. ( 0,49466542963938 )
BMC Med Inform Decis Mak - An innovative approach to near-infrared spectroscopy using a standard mobile device and its clinical application in the real-time visualization of peripheral veins. ( 0,493104090399137 )
J. Comput. Biol. - Separating significant matches from spurious matches in DNA sequences. ( 0,491653512691026 )
J Biomed Inform - A framework for unifying ontology-based semantic similarity measures: a study in the biomedical domain. ( 0,491605727584857 )
J Clin Monit Comput - A novel airway device with tactile sensing capabilities for verifying correct endotracheal tube placement. ( 0,487914470306613 )
IEEE J Biomed Health Inform - A Visual Analytics Approach Using the Exploration of Multidimensional Feature Spaces for Content-Based Medical Image Retrieval. ( 0,487658123605469 )
Artif Intell Med - Intra-axiom redundancies in SNOMED CT. ( 0,48681176053025 )
Int J Med Inform - Designing for healthy living: supporting reflectivity on interactions in healthcare. ( 0,486104878210595 )
J Am Med Inform Assoc - Comparison of two kinds of interface, based on guided navigation or usability principles, for improving the adoption of computerized decision support systems: application to the prescription of antibiotics. ( 0,48596127590959 )
J Chem Inf Model - Improving similarity-driven library design: customized matching and regioselective feature trees. ( 0,482416124766132 )
J Chem Inf Model - OOMMPPAA: a tool to aid directed synthesis by the combined analysis of activity and structural data. ( 0,482341229032404 )
Methods Inf Med - The utility of imputed matched sets. Analyzing probabilistically linked databases in a low information setting. ( 0,481808583910442 )
Comput. Aided Surg. - Use of finite element analysis of a Lenke type 5 adolescent idiopathic scoliosis case to assess possible surgical outcomes. ( 0,480871952651491 )
AMIA Annu Symp Proc - Dissimilarities in the Logical Modeling of Apparently Similar Concepts in SNOMED CT. ( 0,479951952772794 )
J Biomed Inform - SNOMED CT module-driven clinical archetype management. ( 0,477206447404548 )
J Biomed Inform - Secondary use of clinical data: the Vanderbilt approach. ( 0,474664791214801 )
AMIA Annu Symp Proc - Using SemRep to label semantic relations extracted from clinical text. ( 0,47401387950126 )
Int J Med Robot - Preliminary study of a novel method for conveying corrected image volumes in surgical navigation. ( 0,47282141766473 )
J Biomed Inform - Knowledge-based personalized search engine for the Web-based Human Musculoskeletal System Resources (HMSR) in biomechanics. ( 0,472520482631205 )
Telemed J E Health - User-friendly cognitive training for the elderly: a technical report. ( 0,471835099657817 )
Inform Health Soc Care - A novel multimodal tool for telemonitoring patients with COPD. ( 0,47165359145688 )
J Chem Inf Model - Machine learning methods for property prediction in chemoinformatics: Quo Vadis? ( 0,471489820714649 )
IEEE Trans Pattern Anal Mach Intell - On Kleinberg's Stochastic Discrimination Procedure. ( 0,469203610837241 )
J. Med. Internet Res. - Cumulative query method for influenza surveillance using search engine data. ( 0,468893684591667 )
J Chem Inf Model - Modeling flexible pharmacophores with distance geometry, scoring, and bound stretching. ( 0,46800354195818 )
Int J Med Inform - Design and implementation of a seamless and comprehensive integrated medical device interface system for outpatient electronic medical records in a general hospital. ( 0,467692525434275 )
J Am Med Inform Assoc - A multi-part matching strategy for mapping LOINC with laboratory terminologies. ( 0,466116444364807 )
IEEE J Biomed Health Inform - An ontology-based annotation of cardiac implantable electronic devices to detect therapy changes in a national registry. ( 0,464133064038522 )
Methods Inf Med - Communication architecture for AAL. Supporting patient care by health care providers in AAL-enhanced living quarters. ( 0,463817649075801 )
J Biomed Inform - Semantic integration of information about orthologs and diseases: the OGO system. ( 0,463332143572846 )
J Biomed Inform - ReVeaLD: a user-driven domain-specific interactive search platform for biomedical research. ( 0,462108835367846 )
Int J Med Inform - A usability evaluation of a SNOMED CT based compositional interface terminology for intensive care. ( 0,461550632038445 )
Telemed J E Health - Measuring the effect of telecare on medical expenditures without bias using the propensity score matching method. ( 0,461041800727539 )
Appl Clin Inform - Telemonitoring of patients with Parkinson's disease using inertia sensors. ( 0,459589392505437 )
J Am Med Inform Assoc - Easily configured real-time CPOE Pick Off Tool supporting focused clinical research and quality improvement. ( 0,459151467006974 )
Comput. Biol. Med. - A bilateral analysis scheme for false positive reduction in mammogram mass detection. ( 0,458324309269307 )
Int J Comput Assist Radiol Surg - A modular video streaming method for surgical assistance in operating room networks. ( 0,457971714388269 )
AMIA Annu Symp Proc - Ensuring patient safety in care transitions: an empirical evaluation of a Handoff Intervention Tool. ( 0,456954848557014 )
Med Biol Eng Comput - User interaction in smart ambient environment targeted for senior citizen. ( 0,456008846180268 )
Comput Math Methods Med - Space constrained homology modelling: the paradigm of the RNA-dependent RNA polymerase of dengue (type II) virus. ( 0,456000210470541 )
IEEE Trans Vis Comput Graph - WORDGRAPH: Keyword-in-Context Visualization for NETSPEAK's Wildcard Search. ( 0,455926519865594 )
AMIA Annu Symp Proc - Medication Reconciliation: Work Domain Ontology, prototype development, and a predictive model. ( 0,455852098264109 )
J Med Syst - Standardization on body area network and a prototype system based on UWB. ( 0,454722504046345 )
Comput Methods Programs Biomed - A new fibre optic pulse oximeter probe for monitoring splanchnic organ arterial blood oxygen saturation. ( 0,454475784534985 )
Comput Biol Chem - Understanding the general packing rearrangements required for successful template based modeling of protein structure from a CASP experiment. ( 0,45408463737341 )
Comput. Aided Surg. - Efficacy and accuracy of a novel rapid prototyping drill template for cervical pedicle screw placement. ( 0,452635438636639 )
Int J Health Geogr - Web GIS in practice X: a Microsoft Kinect natural user interface for Google Earth navigation. ( 0,452578395059283 )
AMIA Annu Symp Proc - New abstraction networks and a new visualization tool in support of auditing the SNOMED CT content. ( 0,452244973396059 )
J Am Med Inform Assoc - MCORES: a system for noun phrase coreference resolution for clinical records. ( 0,451757792554836 )
AMIA Annu Symp Proc - A Service Oriented Architecture Approach to Achieve Interoperability between Immunization Information Systems in Iran. ( 0,451183753729041 )
J Am Med Inform Assoc - Design and usability study of an iconic user interface to ease information retrieval of medical guidelines. ( 0,450749288885252 )
J Biomed Inform - An analysis of FMA using structural self-bisimilarity. ( 0,450726928241698 )
Res Synth Methods - A standardized mean difference effect size for single case designs. ( 0,450240317335179 )
J Biomed Inform - COnto-Diff: generation of complex evolution mappings for life science ontologies. ( 0,448994476516031 )
Int J Comput Assist Radiol Surg - Stent graft visualization and planning tool for endovascular surgery using finite element analysis. ( 0,448425948693618 )
Comput Methods Programs Biomed - TGI-Simulator: a visual tool to support the preclinical phase of the drug discovery process by assessing in silico the effect of an anticancer drug. ( 0,448372366284194 )
Comput Biol Chem - Macroscopic simulations of microtubule dynamics predict two steady-state processes governing array morphology. ( 0,44794196717291 )
Artif Intell Med - Intelligent visualization and exploration of time-oriented data of multiple patients. ( 0,447305233422224 )
Int J Med Inform - A study of the influence of task familiarity on user behaviors and performance with a MeSH term suggestion interface for PubMed bibliographic search. ( 0,446568372546165 )
AMIA Annu Symp Proc - Semantic Similarity and Relatedness between Clinical Terms: An Experimental Study. ( 0,445715650313951 )
Comput Methods Programs Biomed - Assessing bone loss in micro-gravity: a fuzzy approach. ( 0,445652635779262 )
J Biomed Inform - Modeling workflow to design machine translation applications for public health practice. ( 0,444936456166831 )
J. Med. Internet Res. - A search engine to access PubMed monolingual subsets: proof of concept and evaluation in French. ( 0,44491971030466 )
IEEE Trans Pattern Anal Mach Intell - A Co-Prime Blur Scheme for Data Security in Video Surveillance. ( 0,444509974392536 )
Telemed J E Health - Heuristic evaluation and usability testing of a computerized patient-reported outcomes survey for headache sufferers. ( 0,443947659858965 )
J Chem Inf Model - Exploiting structural information in patent specifications for key compound prediction. ( 0,443891949893052 )
Comput. Biol. Med. - PRoSPer: perceptual similarity queries in medical CBIR systems through user profiles. ( 0,443667273236595 )
J Biomed Inform - Enabling semantic similarity estimation across multiple ontologies: an evaluation in the biomedical domain. ( 0,443225787411126 )
Artif Intell Med - Inconsistency as a diagnostic tool in a society of intelligent agents. ( 0,442889171124714 )
IEEE Trans Image Process - Interval-valued fuzzy sets applied to stereo matching of color images. ( 0,442548707989436 )
AMIA Annu Symp Proc - Expressing observations from electronic medical record flowsheets in an i2b2 based clinical data repository to support research and quality improvement. ( 0,441825338916851 )
J Med Syst - Intelligent personal health record: experience and open issues. ( 0,441713639264724 )
Int J Neural Syst - Design of assistive wheelchair system directly steered by human thoughts. ( 0,441533311174227 )
Artif Intell Med - A semantic graph-based approach to biomedical summarisation. ( 0,441477360279688 )
Telemed J E Health - Challenges of a mobile application for asthma and allergic rhinitis patient enablement-interface and synchronization. ( 0,440189446177944 )
J Biomed Inform - Supporting retrieval of diverse biomedical data using evidence-aware queries. ( 0,439251894881488 )
Comput Math Methods Med - Effective admittivity of biological tissues as a coefficient of elliptic PDE. ( 0,439096299140628 )
J Am Med Inform Assoc - BiobankConnect: software to rapidly connect data elements for pooled analysis across biobanks using ontological and lexical indexing. ( 0,438231083917424 )