J Chem Inf Model - Discovery of inhibitors of Schistosoma mansoni HDAC8 by combining homology modeling, virtual screening, and in vitro validation.

Tópicos

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{ age(1611) year(1155) adult(843) }
{ medic(1828) order(1363) alert(1069) }
{ signal(2180) analysi(812) frequenc(800) }
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{ group(2977) signific(1463) compar(1072) }
{ sampl(1606) size(1419) use(1276) }
{ data(3008) multipl(1320) sourc(1022) }
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{ method(1969) cluster(1462) data(1082) }
{ method(2212) result(1239) propos(1039) }

Resumo

Schistosomiasis, caused by S. mansoni, is a tropical disease that affects over 200 million people worldwide. A novel approach for targeting eukaryotic parasites is to tackle their dynamic epigenetic machinery that is necessary for the extensive phenotypic changes during their life cycle. We recently identified S. mansoni histone deacetylase 8 (smHDAC8) as a potential target for antiparasitic therapy. Here we present results from a virtual screening campaign on smHDAC8. Besides hydroxamates, several sulfonamide-thiazole derivatives were identified by a target-based virtual screening using a homology model of smHDAC8. In vitro testing of 75 compounds identified 8 hydroxamates as potent and lead-like inhibitors of the parasitic HDAC8. Solving of the crystal structure of smHDAC8 with two of the virtual screening hits confirmed the predicted binding mode.

Resumo Limpo

schistosomiasi caus s mansoni tropic diseas affect million peopl worldwid novel approach target eukaryot parasit tackl dynam epigenet machineri necessari extens phenotyp chang life cycl recent identifi s mansoni histon deacetylas smhdac potenti target antiparasit therapi present result virtual screen campaign smhdac besid hydroxam sever sulfonamidethiazol deriv identifi targetbas virtual screen use homolog model smhdac vitro test compound identifi hydroxam potent leadlik inhibitor parasit hdac solv crystal structur smhdac two virtual screen hit confirm predict bind mode

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