Artif Intell Med - Multi-agent model of hepatitis C virus infection.

Tópicos

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Resumo

JECTIVES: The objective of this study is to design a method for modeling hepatitis C virus (HCV) infection using multi-agent simulation and to verify it in practice.METHODS AND MATERIALS: In this paper, first, the modeling of HCV infection using a multi-agent system is compared with the most commonly used model type, which is based on differential equations. Then, the implementation and results of the model using a multi-agent simulation is presented. To find the values of the parameters used in the model, a method using inverted simulation flow and genetic algorithm is proposed. All of the data regarding HCV infection are taken from the paper describing the model based on the differential equation to which the proposed method is compared.RESULTS: Important advantages of the proposed method are noted and demonstrated: these include flexibility, clarity, re-usability and the possibility to model more complex dependencies. Then, the simulation framework that uses the proposed approach is successfully implemented in C++ and is verified by comparing it to the approach based on differential equations. The verification proves that an objective function that performs the best is the function that minimizes the maximal differences in the data. Finally, an analysis of one of the already known models is performed, and it is proved that it incorrectly models a decay in the hepatocytes number by 40%.CONCLUSIONS: The proposed method has many advantages in comparison to the currently used model types and can be used successfully for analyzing HCV infection. With almost no modifications, it can also be used for other types of viral infections.

Resumo Limpo

jectiv object studi design method model hepat c virus hcv infect use multiag simul verifi practicemethod materi paper first model hcv infect use multiag system compar common use model type base differenti equat implement result model use multiag simul present find valu paramet use model method use invert simul flow genet algorithm propos data regard hcv infect taken paper describ model base differenti equat propos method comparedresult import advantag propos method note demonstr includ flexibl clariti reusabl possibl model complex depend simul framework use propos approach success implement c verifi compar approach base differenti equat verif prove object function perform best function minim maxim differ data final analysi one alreadi known model perform prove incorrect model decay hepatocyt number conclus propos method mani advantag comparison current use model type can use success analyz hcv infect almost modif can also use type viral infect

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