J Clin Monit Comput - Multimodal noninvasive monitoring of soft tissue wound healing.


{ blood(1257) pressur(1144) flow(957) }
{ assess(1506) score(1403) qualiti(1306) }
{ signal(2180) analysi(812) frequenc(800) }
{ chang(1828) time(1643) increas(1301) }
{ studi(2440) review(1878) systemat(933) }
{ treatment(1704) effect(941) patient(846) }
{ perform(1367) use(1326) method(1137) }
{ use(1733) differ(960) four(931) }
{ imag(2675) segment(2577) method(1081) }
{ clinic(1479) use(1117) guidelin(835) }
{ model(2220) cell(1177) simul(1124) }
{ care(1570) inform(1187) nurs(1089) }
{ monitor(1329) mobil(1314) devic(1160) }
{ time(1939) patient(1703) rate(768) }
{ inform(2794) health(2639) internet(1427) }
{ measur(2081) correl(1212) valu(896) }
{ surgeri(1148) surgic(1085) robot(1054) }
{ activ(1452) weight(1219) physic(1104) }
{ method(1969) cluster(1462) data(1082) }
{ model(3480) simul(1196) paramet(876) }
{ ehr(2073) health(1662) electron(1139) }
{ use(976) code(926) identifi(902) }
{ process(1125) use(805) approach(778) }
{ data(1737) use(1416) pattern(1282) }
{ framework(1458) process(801) describ(734) }
{ method(1557) propos(1049) approach(1037) }
{ data(1714) softwar(1251) tool(1186) }
{ general(901) number(790) one(736) }
{ case(1353) use(1143) diagnosi(1136) }
{ system(1050) medic(1026) inform(1018) }
{ spatial(1525) area(1432) region(1030) }
{ state(1844) use(1261) util(961) }
{ patient(2837) hospit(1953) medic(668) }
{ model(2656) set(1616) predict(1553) }
{ group(2977) signific(1463) compar(1072) }
{ data(3008) multipl(1320) sourc(1022) }
{ first(2504) two(1366) second(1323) }
{ health(1844) social(1437) communiti(874) }
{ implement(1333) system(1263) develop(1122) }
{ model(3404) distribut(989) bayesian(671) }
{ can(774) often(719) complex(702) }
{ imag(1947) propos(1133) code(1026) }
{ system(1976) rule(880) can(841) }
{ imag(1057) registr(996) error(939) }
{ bind(1733) structur(1185) ligand(1036) }
{ sequenc(1873) structur(1644) protein(1328) }
{ method(1219) similar(1157) match(930) }
{ featur(3375) classif(2383) classifi(1994) }
{ imag(2830) propos(1344) filter(1198) }
{ network(2748) neural(1063) input(814) }
{ patient(2315) diseas(1263) diabet(1191) }
{ take(945) account(800) differ(722) }
{ motion(1329) object(1292) video(1091) }
{ problem(2511) optim(1539) algorithm(950) }
{ error(1145) method(1030) estim(1020) }
{ learn(2355) train(1041) set(1003) }
{ concept(1167) ontolog(924) domain(897) }
{ algorithm(1844) comput(1787) effici(935) }
{ extract(1171) text(1153) clinic(932) }
{ design(1359) user(1324) use(1319) }
{ control(1307) perform(991) simul(935) }
{ method(984) reconstruct(947) comput(926) }
{ search(2224) databas(1162) retriev(909) }
{ featur(1941) imag(1645) propos(1176) }
{ howev(809) still(633) remain(590) }
{ data(3963) clinic(1234) research(1004) }
{ studi(1410) differ(1259) use(1210) }
{ risk(3053) factor(974) diseas(938) }
{ perform(999) metric(946) measur(919) }
{ research(1085) discuss(1038) issu(1018) }
{ import(1318) role(1303) understand(862) }
{ model(2341) predict(2261) use(1141) }
{ visual(1396) interact(850) tool(830) }
{ compound(1573) activ(1297) structur(1058) }
{ studi(1119) effect(1106) posit(819) }
{ record(1888) medic(1808) patient(1693) }
{ health(3367) inform(1360) care(1135) }
{ research(1218) medic(880) student(794) }
{ data(2317) use(1299) case(1017) }
{ age(1611) year(1155) adult(843) }
{ medic(1828) order(1363) alert(1069) }
{ cost(1906) reduc(1198) effect(832) }
{ sampl(1606) size(1419) use(1276) }
{ gene(2352) biolog(1181) express(1162) }
{ intervent(3218) particip(2042) group(1664) }
{ activ(1138) subject(705) human(624) }
{ patient(1821) servic(1111) care(1106) }
{ use(2086) technolog(871) perceiv(783) }
{ can(981) present(881) function(850) }
{ analysi(2126) use(1163) compon(1037) }
{ structur(1116) can(940) graph(676) }
{ high(1669) rate(1365) level(1280) }
{ cancer(2502) breast(956) screen(824) }
{ drug(1928) target(777) effect(648) }
{ result(1111) use(1088) new(759) }
{ survey(1388) particip(1329) question(1065) }
{ estim(2440) model(1874) function(577) }
{ decis(3086) make(1611) patient(1517) }
{ method(2212) result(1239) propos(1039) }
{ detect(2391) sensit(1101) algorithm(908) }


Here we report results of non-invasive measurements of indirect markers of soft tissue healing of traumatic wounds in an observational swine study and describe the quantification of analog physiological signals. The primary purpose of the study was to measure bone healing of fractures with four different wound treatments. A second purpose was to quantify soft tissue wound healing by measuring the following indirect markers: (1) tissue oxygenation, (2) fluid content, and (3) blood flow, which were all measured by non-invasive modalities, measured with available devices. Tissue oxygenation was measured by near infrared spectroscopy; fluid content was measured by bipolar bio-impedance; and blood flow was measured by Doppler ultrasound. Immediately after comminuted femur fractures were produced in the right hind legs of thirty anesthetized female Yorkshire swine, one of four wound treatments was instilled into each wound. The four wound treatments were as follows: salmon fibrinogen/thrombin-n?=?8; commercial bone filler matrix-n?=?7; bovine collagen-n?=?8; porcine fibrinogen/thrombin-n?=?7. Fractures were stabilized with an external fixation device. Immediately following wound treatments, measurements were made of tissue oxygenation, fluid content and blood flow; these measurements were repeated weekly for 3?weeks after surgery. Analog signals of each modality were recorded on both the wounded (right) hind leg and the healthy (left) hind leg, for comparison purposes. Data were processed off-line. The mean values of 10-s periods were calculated for right-left leg comparison. ANOVA was applied for statistical analysis. Results of the bone healing studies are published separately (Rothwell et al. in J Spec Oper Med 13:7-18, 2013). For soft tissue wounds, healing did not differ significantly among the four wound treatments; however, regional oxygenation of wounds treated with salmon fibrinogen/thrombin showed slightly different time trends. Further studies are needed to establish standards for healthy wound healing and for detection of pathological alterations such as infection. Non-invasive measurement and quantification of indirect markers of soft tissue wound healing support the goals and principles of evidence-based medicine and show potential as easy to administer tools for clinicians and battlefield medical personnel to apply when procedures such as the PET scan are not available or affordable. The method we developed for storing analog physiological signals could be used for maintaining electronic health records, by incorporating vital signs such as ECG and EEG, etc.

Resumo Limpo

report result noninvas measur indirect marker soft tissu heal traumat wound observ swine studi describ quantif analog physiolog signal primari purpos studi measur bone heal fractur four differ wound treatment second purpos quantifi soft tissu wound heal measur follow indirect marker tissu oxygen fluid content blood flow measur noninvas modal measur avail devic tissu oxygen measur near infrar spectroscopi fluid content measur bipolar bioimped blood flow measur doppler ultrasound immedi comminut femur fractur produc right hind leg thirti anesthet femal yorkshir swine one four wound treatment instil wound four wound treatment follow salmon fibrinogenthrombinn commerci bone filler matrixn bovin collagenn porcin fibrinogenthrombinn fractur stabil extern fixat devic immedi follow wound treatment measur made tissu oxygen fluid content blood flow measur repeat week week surgeri analog signal modal record wound right hind leg healthi left hind leg comparison purpos data process offlin mean valu s period calcul rightleft leg comparison anova appli statist analysi result bone heal studi publish separ rothwel et al j spec oper med soft tissu wound heal differ signific among four wound treatment howev region oxygen wound treat salmon fibrinogenthrombin show slight differ time trend studi need establish standard healthi wound heal detect patholog alter infect noninvas measur quantif indirect marker soft tissu wound heal support goal principl evidencebas medicin show potenti easi administ tool clinician battlefield medic personnel appli procedur pet scan avail afford method develop store analog physiolog signal use maintain electron health record incorpor vital sign ecg eeg etc

Resumos Similares

Comput Math Methods Med - Simulation of exercise-induced syncope in a heart model with severe aortic valve stenosis. ( 0,820060427731568 )
J Clin Monit Comput - Impact of central hypovolemia on photoplethysmographic waveform parameters in healthy volunteers part 2: frequency domain analysis. ( 0,81404744641558 )
Med Biol Eng Comput - Effect of respiration on Korotkoff sounds and oscillometric cuff pressure pulses during blood pressure measurement. ( 0,813284257306667 )
J Clin Monit Comput - Bench test assessment of mainstream capnography during high frequency oscillatory ventilation. ( 0,809104135373437 )
J Clin Monit Comput - Tako-tsubo cardiomyopathy and microcirculation. ( 0,795553378127483 )
Health Informatics J - Reliability and concurrent validity of a peripheral pulse oximeter and health-app system for the quantification of heart rate in healthy adults. ( 0,783936727394914 )
Med Biol Eng Comput - Coronary-aortic interaction during ventricular isovolumic contraction. ( 0,775474322170897 )
Comput Math Methods Med - A new high-resolution spectral approach to noninvasively evaluate wall deformations in arteries. ( 0,766622701370949 )
Comput Math Methods Med - Evaluation of a model-based hemodynamic monitoring method in a porcine study of septic shock. ( 0,764909970110426 )
J Clin Monit Comput - An evaluation and comparison of intraventricular, intraparenchymal, and fluid-coupled techniques for intracranial pressure monitoring in patients with severe traumatic brain injury. ( 0,761496569136884 )
J Clin Monit Comput - The use of regional cerebral oximetry monitoring during controlled hypotension: a case series. ( 0,751621328824752 )
J Clin Monit Comput - Assessment of cerebral oxygenation using near infrared spectroscopy during isovolemic hemodilution in pediatric patients. ( 0,751497309568442 )
Med Biol Eng Comput - Investigation of photoplethysmographic signals and blood oxygen saturation values on healthy volunteers during cuff-induced hypoperfusion using a multimode PPG/SpO2 sensor. ( 0,750267017392372 )
J Clin Monit Comput - In-line pressure within a HOTLINE? Fluid Warmer, under various flow conditions. ( 0,748055424365369 )
J Clin Monit Comput - Heart sounds analysis via esophageal stethoscope system in beagles. ( 0,74619822085694 )
J Clin Monit Comput - Radial-femoral concordance in time and frequency domain-based estimates of systemic arterial respiratory variation. ( 0,744840990126621 )
J Clin Monit Comput - Radial artery cannulation decreases the distal arterial blood flow measured by power Doppler ultrasound. ( 0,743696722802142 )
Comput. Biol. Med. - The hemodynamic alterations induced by the vascular angular deformation in stent-assisted coiling of bifurcation aneurysms. ( 0,742561393607186 )
Comput Math Methods Med - Investigating properties of the cardiovascular system using innovative analysis algorithms based on ensemble empirical mode decomposition. ( 0,741517804772513 )
J Clin Monit Comput - The changes of pulmonary blood flow in non-ventilated lung during one lung ventilation. ( 0,741429533735954 )
J Clin Monit Comput - Validation of the new Complior sensor to record pressure signals non-invasively. ( 0,739101064692841 )
Comput Math Methods Med - Numerical study for blood flow in pulmonary arteries after repair of tetralogy of Fallot. ( 0,738912742434686 )
Med Biol Eng Comput - Time delay correction of the synchrogram for optimized detection of cardiorespiratory coordination. ( 0,73795541473184 )
Comput Methods Programs Biomed - In silico study of the haemodynamic effects induced by mechanical ventilation and biventricular pacemaker. ( 0,735798211678095 )
Comput. Biol. Med. - Effect of CPAP therapy on daytime cardiovascular regulations in patients with obstructive sleep apnea. ( 0,734032337167977 )
J Clin Monit Comput - Changes in R-Wave amplitude in DII lead is less sensitive than pulse pressure variation to detect changes in stroke volume after fluid challenge in ICU patients postoperatively to cardiac surgery. ( 0,734001674931153 )
J Med Syst - The advantages of wearable green reflected photoplethysmography. ( 0,733355994370217 )
J Clin Monit Comput - Noninvasive continuous hemodynamic monitoring. ( 0,732460201356177 )
J Clin Monit Comput - Assessment of the effect of rapid crystalloid infusion on stroke volume variation and pleth variability index after a preoperative fast. ( 0,732400791096635 )
Med Biol Eng Comput - Arterial reservoir-excess pressure and ventricular work. ( 0,731910563884245 )
Med Biol Eng Comput - Monitoring intracellular, interstitial, and intravascular volume changes during fluid management procedures. ( 0,730972391219677 )
J Clin Monit Comput - Cardiopulmonary interactions and volume status assessment. ( 0,730680177579689 )
Comput Methods Programs Biomed - Measurements of the left atrium and pulmonary veins for analysis of reverse structural remodeling following cardiac ablation therapy. ( 0,729112438911402 )
J Clin Monit Comput - Continuous minimally invasive peri-operative monitoring of cardiac output by pulmonary capnotracking: comparison with thermodilution and transesophageal echocardiography. ( 0,72795758998006 )
J Clin Monit Comput - The relationship between the area of peripherally-derived pressure volume loops and systemic vascular resistance. ( 0,727563568446777 )
J Clin Monit Comput - Continuous measurement of cardiac output with the electrical velocimetry method in patients under spinal anesthesia for cesarean delivery. ( 0,726701756542424 )
J Clin Monit Comput - Analysis of plethysmographic waveform changes induced by beach chair positioning under general anesthesia. ( 0,725861466497756 )
Comput Methods Programs Biomed - A model of perfusion of the healthy human lung. ( 0,725310017714234 )
J Clin Monit Comput - Pulmonary artery pulsatility is the main cause of cardiogenic oscillations. ( 0,724855509842812 )
J Clin Monit Comput - The transpulmonary thermodilution technique. ( 0,724214627070283 )
Med Biol Eng Comput - A coupled flow-acoustic computational study of bruits from a modeled stenosed artery. ( 0,723163693017576 )
J Clin Monit Comput - Impact of central hypovolemia on photoplethysmographic waveform parameters in healthy volunteers. Part 1: time domain analysis. ( 0,722553133654094 )
J Clin Monit Comput - Arterial line for monitoring SpO2 in patients with ischemic peripheries. ( 0,720910378584927 )
J Clin Monit Comput - Hemodynamic volumetry using transpulmonary ultrasound dilution (TPUD) technology in a neonatal animal model. ( 0,719970439833247 )
Med Biol Eng Comput - Assessment of dynamic cerebral autoregulation and cerebral carbon dioxide reactivity during normothermic cardiopulmonary bypass. ( 0,719410404288504 )
J Clin Monit Comput - A web-based Italian survey of current trends, habits and beliefs in hemodynamic monitoring and management. ( 0,719215667797221 )
Comput Methods Programs Biomed - Mechanical ventilation and thoracic artificial lung assistance during mechanical circulatory support with PUCA pump: in silico study. ( 0,715391051594053 )
J Clin Monit Comput - Continuous real time endotracheal tube cuff pressure waveform. ( 0,714845877972052 )
Med Biol Eng Comput - Model-based correction of the influence of body position on continuous segmental and hand-to-foot bioimpedance measurements. ( 0,714625324773768 )
J Clin Monit Comput - Comparison of cardiac output determined by bioimpedance and bioreactance methods at rest and during exercise. ( 0,71366856473238 )
J Clin Monit Comput - Transesophageal echocardiography and intraoperative phlebotomy during surgical repair of coarctation of aorta in a patient with atrial septal defect, moderately severe mitral regurgitation and severe pulmonary hypertension. ( 0,713662046764998 )
J Clin Monit Comput - A comparative study of pulse rate variability and heart rate variability in healthy subjects. ( 0,712874577066817 )
J Clin Monit Comput - Decrease in pulmonary artery pressure after administration of thoracic epidural anesthesia in a patient with Marfan syndrome awaiting aortic valve replacement procedure. ( 0,712720967900198 )
J Clin Monit Comput - Evaluation of a CO2 partial rebreathing functional residual capacity measurement method for use during mechanical ventilation. ( 0,712439919542526 )
Comput Math Methods Med - CFD modelling of abdominal aortic aneurysm on hemodynamic loads using a realistic geometry with CT. ( 0,712143513532178 )
Med Biol Eng Comput - Enhanced phase synchronization of blood flow oscillations between heated and adjacent non-heated sacral skin. ( 0,711589709427108 )
Med Biol Eng Comput - Mechanical behaviour and rupture of normal and pathological human ascending aortic wall. ( 0,710875601429432 )
J Clin Monit Comput - Transthoracic electrical bioimpedence cardiac output: comparison with multigated equillibrium radionuclide cardiography. ( 0,709205677500907 )
J Med Syst - Human cardiovascular model and applications. ( 0,708320836312936 )
Comput Math Methods Med - Mathematical analysis of non-Newtonian blood flow in stenosis narrow arteries. ( 0,707667485587615 )
J Clin Monit Comput - Arterial pressure waveform derived cardiac output FloTrac/Vigileo system (third generation software): comparison of two monitoring sites with the thermodilution cardiac output. ( 0,706814706630117 )
J Clin Monit Comput - Capability of a new paediatric oesophageal Doppler monitor to detect changes in cardiac output during testing of external pacemakers after cardiac surgery. ( 0,705889720384609 )
J Clin Monit Comput - Evaluation of mean systemic filling pressure from pulse contour cardiac output and central venous pressure. ( 0,705454828419823 )
J Clin Monit Comput - The mean prehospital machine; accurate prehospital non-invasive blood pressure measurement in the critically ill patient. ( 0,704861271485977 )
Comput Math Methods Med - Plasma volume expansion resulting from intravenous glucose tolerance test. ( 0,704761964568931 )
Comput Math Methods Med - Computational fluid dynamics simulations of contrast agent bolus dispersion in a coronary bifurcation: impact on MRI-based quantification of myocardial perfusion. ( 0,704645148267411 )
J Clin Monit Comput - Variations in the pre-ejection period induced by deep breathing do not predict the hemodynamic response to early haemorrhage in healthy volunteers. ( 0,70429074114607 )
Med Biol Eng Comput - The effect of aortic wall and aortic leaflet stiffening on coronary hemodynamic: a fluid-structure interaction study. ( 0,704247290513189 )
J Clin Monit Comput - Noninvasive intracranial pressure measurement using infrasonic emissions from the tympanic membrane. ( 0,703410242474933 )
J Clin Monit Comput - Impact of skin incision on the pleth variability index. ( 0,702802615511531 )
Med Biol Eng Comput - Transesophageal left ventricular electrogram-recording and temporary pacing to improve patient selection for cardiac resynchronization. ( 0,702682338915373 )
J Clin Monit Comput - Reference values for volumetric capnography-derived non-invasive parameters in healthy individuals. ( 0,702320433990808 )
Med Biol Eng Comput - A technique based on laser Doppler flowmetry and photoplethysmography for simultaneously monitoring blood flow at different tissue depths. ( 0,701329369220496 )
J Clin Monit Comput - USCOM-window to the circulation: utility of supra-sternal Doppler in an elderly anaesthetized patient for a robotic cystectomy. ( 0,701116551358489 )
Comput Math Methods Med - Simulation of the Frank-Starling Law of the Heart. ( 0,700332927142567 )
Med Biol Eng Comput - Computational model for estimating the short- and long-term cardiac response to arteriovenous fistula creation for hemodialysis. ( 0,700315273420075 )
Comput Methods Programs Biomed - Impact of pulmonary vascular stiffness and vasodilator treatment in pediatric pulmonary hypertension: 21 patient-specific fluid-structure interaction studies. ( 0,699814879796516 )
Med Biol Eng Comput - Determinants of vascular and cardiac baroreflex sensitivity values in a random population sample. ( 0,699141017178805 )
J Clin Monit Comput - The use of heart rate variability for the early detection of treatable complications after aneurysmal subarachnoid hemorrhage. ( 0,698421853533782 )
Med Biol Eng Comput - Characterization of skin dermis microcirculation in flow-mediated dilation using optical sensor with pressurization mechanism. ( 0,697417676559056 )
Comput. Biol. Med. - Biomechanical behaviors of curved artery with flexible wall: a numerical study using fluid-structure interaction method. ( 0,695285895468899 )
Comput. Biol. Med. - Computational analysis of the importance of flow synchrony for cardiac ventricular assist devices. ( 0,69487990562476 )
J Clin Monit Comput - Bedside assessment of passive leg raising effects on venous return. ( 0,693099259331561 )
Med Biol Eng Comput - Detrended fluctuation analysis of blood pressure in preterm infants with intraventricular hemorrhage. ( 0,692755123618 )
J Clin Monit Comput - Partitioning the resistances along the vascular tree: effects of dobutamine and hypovolemia in piglets with an intact circulation. ( 0,692566924952463 )
J Clin Monit Comput - Continuous non-invasive monitoring improves blood pressure stability in upright position: randomized controlled trial. ( 0,691976681287257 )
Med Biol Eng Comput - Cardiac oxygen supply is compromised during the night in hypertensive patients. ( 0,68993495175508 )
J Clin Monit Comput - Accuracy of ultrasound B-lines score and E/Ea ratio to estimate extravascular lung water and its variations in patients with acute respiratory distress syndrome. ( 0,688857370703746 )
Comput. Biol. Med. - Numerical investigation of blood flow in three-dimensional porcine left anterior descending artery with various stenoses. ( 0,68848987841548 )
Med Biol Eng Comput - Non-invasive monitoring of central blood pressure by electrical impedance tomography: first experimental evidence. ( 0,686342731380641 )
J Clin Monit Comput - Respiratory and non-respiratory sinus arrhythmia: implications for heart rate variability. ( 0,686161255078627 )
J Clin Monit Comput - Respiratory change in ECG-wave amplitude is a reliable parameter to estimate intravascular volume status. ( 0,685961321531302 )
J Clin Monit Comput - The effect of endotracheal tube cuff pressure change during gynecological laparoscopic surgery on postoperative sore throat: a control study. ( 0,685571933975129 )
J Clin Monit Comput - The effects of cardiac output and pulmonary arterial hypertension on volumetric capnography derived-variables during normoxia and hypoxia. ( 0,683187566257147 )
Comput Math Methods Med - Impact of competitive flow on hemodynamics in coronary surgery: numerical study of ITA-LAD model. ( 0,683163506283788 )
Comput Methods Programs Biomed - Assessment of ventricular contractility and ventricular-arterial coupling with a model-based sensor. ( 0,68197242467486 )
J Clin Monit Comput - Fluid responsiveness is about stroke volume, and not pulse pressure Yogi: the power of Doppler fluid management and cardiovascular monitoring. ( 0,681423994811588 )
IEEE J Biomed Health Inform - Experimental investigation of the influence of the aortic stiffness on hemodynamics in the ascending aorta. ( 0,681018879306074 )
J Clin Monit Comput - Reliability of a new 4th generation FloTrac algorithm to track cardiac output changes in patients receiving phenylephrine. ( 0,680040195579186 )
Med Biol Eng Comput - Effect of the degree of LAD stenosis on competitive flow and flow field characteristics in LIMA-to-LAD bypass surgery. ( 0,679605245153405 )