J Clin Monit Comput - Lessons learned from closed loops in engineering: towards a multivariable approach regulating depth of anaesthesia.

Tópicos

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Resumo

In this paper is presented a brief state of art regarding the multivariable formulation for controlling the depth of anaesthesia by means of two intravenously administrated drugs, i.e. propofol and remifentanil. In a feasibility study of determining a suitable variable to quantify analgesia levels in patients undergoing cardiac surgery, the bispectral index and an electromyogram-based surrogate variable are proposed as the controlled variables. The study is carried on in the context of implementing a multivariable predictive control algorithm. The simulation results show that such a paradigm is feasible, although it does not guarantee perfect knowledge of the analgesia level-in other words, the variable is not validated against typical evaluations of the pain levels (e.g. clinical scores).

Resumo Limpo

paper present brief state art regard multivari formul control depth anaesthesia mean two intraven administr drug ie propofol remifentanil feasibl studi determin suitabl variabl quantifi analgesia level patient undergo cardiac surgeri bispectr index electromyogrambas surrog variabl propos control variabl studi carri context implement multivari predict control algorithm simul result show paradigm feasibl although guarante perfect knowledg analgesia levelin word variabl valid typic evalu pain level eg clinic score

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