J Clin Monit Comput - Shedding light on mitochondrial function by real time monitoring of NADH fluorescence: I. Basic methodology and animal studies.

Tópicos

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Resumo

Normal mitochondrial function in the process of metabolic energy production is a key factor in maintaining cellular activities. Many pathological conditions in animals, as well as in patients, are directly or indirectly related to dysfunction of the mitochondria. Monitoring the mitochondrial activity by measuring the autofluorescence of NADH has been the most practical approach since the 1950s. This review presents the principles and technological aspects, as well as typical results, accumulated in our laboratory since the early 1970s. We were able to apply the fiber-optic-based NADH fluorometry to many organs monitored in vivo under various pathophysiological conditions in animals. These studies were the basis for the development of clinical monitoring devices as presented in accompanying article. The encouraging experimental results in animals stimulated us to apply the same technology in patients after technological adaptations as described in the accompanying article. Our medical device was approved for clinical use by the FDA.

Resumo Limpo

normal mitochondri function process metabol energi product key factor maintain cellular activ mani patholog condit anim well patient direct indirect relat dysfunct mitochondria monitor mitochondri activ measur autofluoresc nadh practic approach sinc s review present principl technolog aspect well typic result accumul laboratori sinc earli s abl appli fiberopticbas nadh fluorometri mani organ monitor vivo various pathophysiolog condit anim studi basi develop clinic monitor devic present accompani articl encourag experiment result anim stimul us appli technolog patient technolog adapt describ accompani articl medic devic approv clinic use fda

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