J Clin Monit Comput - A knowledge- and model-based system for automated weaning from mechanical ventilation: technical description and first clinical application.


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To describe the principles and the first clinical application of a novel prototype automated weaning system called Evita Weaning System (EWS). EWS allows an automated control of all ventilator settings in pressure controlled and pressure support mode with the aim of decreasing the respiratory load of mechanical ventilation. Respiratory load takes inspired fraction of oxygen, positive end-expiratory pressure, pressure amplitude and spontaneous breathing activity into account. Spontaneous breathing activity is assessed by the number of controlled breaths needed to maintain a predefined respiratory rate. EWS was implemented as a knowledge- and model-based system that autonomously and remotely controlled a mechanical ventilator (Evita 4, Dr?ger Medical, L?beck, Germany). In a selected case study (n?=?19 patients), ventilator settings chosen by the responsible physician were compared with the settings 10?min after the start of EWS and at the end of the study session. Neither unsafe ventilator settings nor failure of the system occurred. All patients were successfully transferred from controlled ventilation to assisted spontaneous breathing in a mean time of 37???17?min (??SD). Early settings applied by the EWS did not significantly differ from the initial settings, except for the fraction of oxygen in inspired gas. During the later course, EWS significantly modified most of the ventilator settings and reduced the imposed respiratory load. A novel prototype automated weaning system was successfully developed. The first clinical application of EWS revealed that its operation was stable, safe ventilator settings were defined and the respiratory load of mechanical ventilation was decreased.

Resumo Limpo

describ principl first clinic applic novel prototyp autom wean system call evita wean system ew ew allow autom control ventil set pressur control pressur support mode aim decreas respiratori load mechan ventil respiratori load take inspir fraction oxygen posit endexpiratori pressur pressur amplitud spontan breath activ account spontan breath activ assess number control breath need maintain predefin respiratori rate ew implement knowledg modelbas system autonom remot control mechan ventil evita drger medic lbeck germani select case studi n patient ventil set chosen respons physician compar set min start ew end studi session neither unsaf ventil set failur system occur patient success transfer control ventil assist spontan breath mean time min sd earli set appli ew signific differ initi set except fraction oxygen inspir gas later cours ew signific modifi ventil set reduc impos respiratori load novel prototyp autom wean system success develop first clinic applic ew reveal oper stabl safe ventil set defin respiratori load mechan ventil decreas

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