J Clin Monit Comput - A comprehensive, computer-model-based approach for diagnosis and treatment of complex acid-base disorders in critically-ill patients.

Tópicos

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Resumo

We have developed a computer-model-based approach to quantitatively diagnose the causes of metabolic acid-base disorders in critically-ill patients. We use an interstitial-plasma-erythrocyte (IPE) model that is sufficiently detailed to accurately calculate steady-state changes from normal in fluid volumes and electrolyte concentrations in a given patient due to a number of causes of acid-base disorders. Normal fluid volumes for each patient are determined from their sex, height and weight using regression equations derived from measured data in humans. The model inputs (electrolyte masses and volumes) are altered to simulate the laboratory chemistry of each critically-ill patient. In this process, the model calculates changes in body-fluid volumes, osmolality and yields the individual values of IPE base excess (BE(IPE)) attributed to changes due to: (1) fluid dilution/contraction, (2) gain or loss of Cl(-), (3) hyper- or hypoalbuminemia, (4) presence of unmeasured ions, (5) gain of lactate, (6) gain or loss of phosphate, (7) gain or loss of calcium and magnesium, (8) gain or loss of potassium and (9) gain or loss of sodium. We use critically-ill patient data to show how our new approach is more informative and much simpler to interpret as compared to the approaches of Siggaard-Andersen or Stewart. We demonstrate how the model can be used at the bedside to diagnose acid-base disorders and suggest appropriate treatment. Hence, this new approach gives clinicians a new tool for diagnosing disorders and specifying fluid-therapy options for critically-ill patients.

Resumo Limpo

develop computermodelbas approach quantit diagnos caus metabol acidbas disord criticallyil patient use interstitialplasmaerythrocyt ipe model suffici detail accur calcul steadyst chang normal fluid volum electrolyt concentr given patient due number caus acidbas disord normal fluid volum patient determin sex height weight use regress equat deriv measur data human model input electrolyt mass volum alter simul laboratori chemistri criticallyil patient process model calcul chang bodyfluid volum osmol yield individu valu ipe base excess beip attribut chang due fluid dilutioncontract gain loss cl hyper hypoalbuminemia presenc unmeasur ion gain lactat gain loss phosphat gain loss calcium magnesium gain loss potassium gain loss sodium use criticallyil patient data show new approach inform much simpler interpret compar approach siggaardandersen stewart demonstr model can use bedsid diagnos acidbas disord suggest appropri treatment henc new approach give clinician new tool diagnos disord specifi fluidtherapi option criticallyil patient

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