J Clin Monit Comput - Improvements in the application and reporting of advanced Bland-Altman methods of comparison.

Tópicos

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Resumo

Bland and Altman have developed a measure called "limits of agreement" to assess correspondence of two methods of clinical measurement. In many circumstances, comparisons are made using several paired measurements in each individual subject. If such measurements are considered as statistically independent pairs, rather than as sets of measurements from separate individuals, limits of agreement will be too narrow. In addition, the confidence intervals for these limits will also be too narrow. Suitable software to compute valid limits of agreement and their confidence intervals is not readily available. Therefore, we set out to provide a freely available implementation accompanied by a formal description of the more advanced Bland-Altman comparison methods. We validate the implementation using simulated data, and demonstrate the effects caused by failing to take the presence of multiple paired measurements per individual properly into account. We propose a standard format of reporting that would improve analysis and interpretation of comparison studies.

Resumo Limpo

bland altman develop measur call limit agreement assess correspond two method clinic measur mani circumst comparison made use sever pair measur individu subject measur consid statist independ pair rather set measur separ individu limit agreement will narrow addit confid interv limit will also narrow suitabl softwar comput valid limit agreement confid interv readili avail therefor set provid freeli avail implement accompani formal descript advanc blandaltman comparison method valid implement use simul data demonstr effect caus fail take presenc multipl pair measur per individu proper account propos standard format report improv analysi interpret comparison studi

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