J Clin Monit Comput - Translational applications of evaluating physiologic variability in human endotoxemia.

Tópicos

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Resumo

Dysregulation of the inflammatory response is a critical component of many clinically challenging disorders such as sepsis. Inflammation is a biological process designed to lead to healing and recovery, ultimately restoring homeostasis; however, the failure to fully achieve those beneficial results can leave a patient in a dangerous persistent inflammatory state. One of the primary challenges in developing novel therapies in this area is that inflammation is comprised of a complex network of interacting pathways. Here, we discuss our approaches towards addressing this problem through computational systems biology, with a particular focus on how the presence of biological rhythms and the disruption of these rhythms in inflammation may be applied in a translational context. By leveraging the information content embedded in physiologic variability, ranging in scale from oscillations in autonomic activity driving short-term heart rate variability to circadian rhythms in immunomodulatory hormones, there is significant potential to gain insight into the underlying physiology.

Resumo Limpo

dysregul inflammatori respons critic compon mani clinic challeng disord sepsi inflamm biolog process design lead heal recoveri ultim restor homeostasi howev failur fulli achiev benefici result can leav patient danger persist inflammatori state one primari challeng develop novel therapi area inflamm compris complex network interact pathway discuss approach toward address problem comput system biolog particular focus presenc biolog rhythm disrupt rhythm inflamm may appli translat context leverag inform content embed physiolog variabl rang scale oscil autonom activ drive shortterm heart rate variabl circadian rhythm immunomodulatori hormon signific potenti gain insight under physiolog

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