J Integr Bioinform - Bioinformatics tools help molecular characterization of Perkinsus olseni differentially expressed genes.

Tópicos

{ gene(2352) biolog(1181) express(1162) }
{ visual(1396) interact(850) tool(830) }
{ data(2317) use(1299) case(1017) }
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{ data(1714) softwar(1251) tool(1186) }
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Resumo

In the 80ies, in Southern Europe and in particular in Ria Formosa there was an episode of heavy mortality of the economically relevant clam Ruditapes (R.) decussatus associated with a debilitating disease (Perkinsosis) caused by Perkinsus olseni. This protozoan parasite was poorly known concerning its' differential transcriptome in response to its host, R. decussatus. This laboratory available protozoan system was used to identify parasite genes related to host interaction. Beyond the application of molecular biology technologies and methodologies, only the help of Bioinformatics tools allowed to analyze the results of the study. The strategy started with SSH technique, allowing the identification of parasite up-regulated genes in response to its natural host, then a macroarray was constructed and hybridized to characterize the parasite genes expression when exposed to bivalves hemolymph from permissive host (R. decussatus), resistant host (R. philippinarum) and non permissive bivalve (Donax trunculus) that cohabit in the same or adjacent habitats in Southern Portugal. Genes and respective peptides full molecular characterization depended on several Bioinformatic tools application. Also a new Bioinformatic tool was developed.

Resumo Limpo

ie southern europ particular ria formosa episod heavi mortal econom relev clam ruditap r decussatus associ debilit diseas perkinsosi caus perkinsus olseni protozoan parasit poor known concern differenti transcriptom respons host r decussatus laboratori avail protozoan system use identifi parasit gene relat host interact beyond applic molecular biolog technolog methodolog help bioinformat tool allow analyz result studi strategi start ssh techniqu allow identif parasit upregul gene respons natur host macroarray construct hybrid character parasit gene express expos bivalv hemolymph permiss host r decussatus resist host r philippinarum non permiss bivalv donax trunculus cohabit adjac habitat southern portug gene respect peptid full molecular character depend sever bioinformat tool applic also new bioinformat tool develop

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