J Integr Bioinform - Inter-dinucleotide distances in the human genome: an analysis of the whole-genome and protein-coding distributions.

Tópicos

{ spatial(1525) area(1432) region(1030) }
{ studi(1119) effect(1106) posit(819) }
{ first(2504) two(1366) second(1323) }
{ system(1976) rule(880) can(841) }
{ imag(1057) registr(996) error(939) }
{ sequenc(1873) structur(1644) protein(1328) }
{ method(1219) similar(1157) match(930) }
{ studi(2440) review(1878) systemat(933) }
{ motion(1329) object(1292) video(1091) }
{ treatment(1704) effect(941) patient(846) }
{ case(1353) use(1143) diagnosi(1136) }
{ can(981) present(881) function(850) }
{ error(1145) method(1030) estim(1020) }
{ search(2224) databas(1162) retriev(909) }
{ risk(3053) factor(974) diseas(938) }
{ import(1318) role(1303) understand(862) }
{ age(1611) year(1155) adult(843) }
{ sampl(1606) size(1419) use(1276) }
{ gene(2352) biolog(1181) express(1162) }
{ time(1939) patient(1703) rate(768) }
{ use(1733) differ(960) four(931) }
{ survey(1388) particip(1329) question(1065) }
{ process(1125) use(805) approach(778) }
{ detect(2391) sensit(1101) algorithm(908) }
{ model(3404) distribut(989) bayesian(671) }
{ can(774) often(719) complex(702) }
{ imag(1947) propos(1133) code(1026) }
{ data(1737) use(1416) pattern(1282) }
{ inform(2794) health(2639) internet(1427) }
{ measur(2081) correl(1212) valu(896) }
{ bind(1733) structur(1185) ligand(1036) }
{ featur(3375) classif(2383) classifi(1994) }
{ imag(2830) propos(1344) filter(1198) }
{ network(2748) neural(1063) input(814) }
{ imag(2675) segment(2577) method(1081) }
{ patient(2315) diseas(1263) diabet(1191) }
{ take(945) account(800) differ(722) }
{ assess(1506) score(1403) qualiti(1306) }
{ surgeri(1148) surgic(1085) robot(1054) }
{ framework(1458) process(801) describ(734) }
{ problem(2511) optim(1539) algorithm(950) }
{ chang(1828) time(1643) increas(1301) }
{ learn(2355) train(1041) set(1003) }
{ concept(1167) ontolog(924) domain(897) }
{ clinic(1479) use(1117) guidelin(835) }
{ algorithm(1844) comput(1787) effici(935) }
{ extract(1171) text(1153) clinic(932) }
{ method(1557) propos(1049) approach(1037) }
{ data(1714) softwar(1251) tool(1186) }
{ design(1359) user(1324) use(1319) }
{ control(1307) perform(991) simul(935) }
{ model(2220) cell(1177) simul(1124) }
{ care(1570) inform(1187) nurs(1089) }
{ general(901) number(790) one(736) }
{ method(984) reconstruct(947) comput(926) }
{ featur(1941) imag(1645) propos(1176) }
{ howev(809) still(633) remain(590) }
{ data(3963) clinic(1234) research(1004) }
{ studi(1410) differ(1259) use(1210) }
{ perform(999) metric(946) measur(919) }
{ research(1085) discuss(1038) issu(1018) }
{ system(1050) medic(1026) inform(1018) }
{ model(2341) predict(2261) use(1141) }
{ visual(1396) interact(850) tool(830) }
{ compound(1573) activ(1297) structur(1058) }
{ perform(1367) use(1326) method(1137) }
{ blood(1257) pressur(1144) flow(957) }
{ record(1888) medic(1808) patient(1693) }
{ health(3367) inform(1360) care(1135) }
{ model(3480) simul(1196) paramet(876) }
{ monitor(1329) mobil(1314) devic(1160) }
{ ehr(2073) health(1662) electron(1139) }
{ state(1844) use(1261) util(961) }
{ research(1218) medic(880) student(794) }
{ patient(2837) hospit(1953) medic(668) }
{ model(2656) set(1616) predict(1553) }
{ data(2317) use(1299) case(1017) }
{ medic(1828) order(1363) alert(1069) }
{ signal(2180) analysi(812) frequenc(800) }
{ cost(1906) reduc(1198) effect(832) }
{ group(2977) signific(1463) compar(1072) }
{ data(3008) multipl(1320) sourc(1022) }
{ intervent(3218) particip(2042) group(1664) }
{ activ(1138) subject(705) human(624) }
{ patient(1821) servic(1111) care(1106) }
{ use(2086) technolog(871) perceiv(783) }
{ analysi(2126) use(1163) compon(1037) }
{ health(1844) social(1437) communiti(874) }
{ structur(1116) can(940) graph(676) }
{ high(1669) rate(1365) level(1280) }
{ cancer(2502) breast(956) screen(824) }
{ use(976) code(926) identifi(902) }
{ drug(1928) target(777) effect(648) }
{ result(1111) use(1088) new(759) }
{ implement(1333) system(1263) develop(1122) }
{ estim(2440) model(1874) function(577) }
{ decis(3086) make(1611) patient(1517) }
{ activ(1452) weight(1219) physic(1104) }
{ method(1969) cluster(1462) data(1082) }
{ method(2212) result(1239) propos(1039) }

Resumo

We study the inter-dinucleotide distance distributions in the human genome, both in the whole-genome and protein-coding regions. The inter-dinucleotide distance is defined as the distance to the next occurrence of the same dinucleotide. We consider the 16 sequences of inter-dinucleotide distances and two reading frames. Our results show a period-3 oscillation in the protein-coding inter-dinucleotide distance distributions that is absent from the whole-genome distributions. We also compare the distance distribution of each dinucleotide to a reference distribution, that of a random sequence generated with the same dinucleotide abundances, revealing the CG dinucleotide as the one with the highest cumulative relative error for the first 60 distances. Moreover, the distance distribution of each dinucleotide is compared to the distance distribution of all other dinucleotides using the Kullback-Leibler divergence. We find that the distance distribution of a dinucleotide and that of its reversed complement are very similar, hence, the divergence between them is very small. This is an interesting finding that may give evidence of a stronger parity rule than Chargaff's second parity rule.

Resumo Limpo

studi interdinucleotid distanc distribut human genom wholegenom proteincod region interdinucleotid distanc defin distanc next occurr dinucleotid consid sequenc interdinucleotid distanc two read frame result show period oscil proteincod interdinucleotid distanc distribut absent wholegenom distribut also compar distanc distribut dinucleotid refer distribut random sequenc generat dinucleotid abund reveal cg dinucleotid one highest cumul relat error first distanc moreov distanc distribut dinucleotid compar distanc distribut dinucleotid use kullbackleibl diverg find distanc distribut dinucleotid revers complement similar henc diverg small interest find may give evid stronger pariti rule chargaff second pariti rule

Resumos Similares

Int J Health Geogr - Density estimation and adaptive bandwidths: a primer for public health practitioners. ( 0,918142757375081 )
Int J Health Geogr - Identifying landscape features associated with Rift Valley fever virus transmission, Ferlo region, Senegal, using very high spatial resolution satellite imagery. ( 0,892185178533256 )
Int J Health Geogr - Geospatial association of endemicity of ataxic polyneuropathy and highly cyanogenic cassava cultivars. ( 0,879436241702736 )
Int J Health Geogr - The effect of spatial aggregation on performance when mapping a risk of disease. ( 0,852777757388196 )
Spat Spatiotemporal Epidemiol - Adjusted significance cutoffs for hypothesis tests applied with generalized additive models with bivariate smoothers. ( 0,852406709049534 )
Int J Health Geogr - A country bug in the city: urban infestation by the Chagas disease vector Triatoma infestans in Arequipa, Peru. ( 0,850313279752212 )
Spat Spatiotemporal Epidemiol - Statistical methods for bivariate spatial analysis in marked points. Examples in spatial epidemiology. ( 0,850242075576883 )
Spat Spatiotemporal Epidemiol - Quantifying the magnitude of environmental exposure misclassification when using imprecise address proxies in public health research. ( 0,840271145607556 )
Spat Spatiotemporal Epidemiol - The rubber plantation environment and Lassa fever epidemics in Liberia, 2008-2012: a spatial regression. ( 0,839760385584784 )
Int J Health Geogr - Agricultural landscape and spatial distribution of Toxoplasma gondii in rural environment: an agent-based model. ( 0,837527860858278 )
Int J Health Geogr - Demarcation of local neighborhoods to study relations between contextual factors and health. ( 0,834110878016908 )
Spat Spatiotemporal Epidemiol - The built environment and depressive symptoms among urban youth: A spatial regression study. ( 0,831846068770221 )
Int J Health Geogr - Alcohol outlets and clusters of violence. ( 0,831737549551084 )
Neural Comput - Optimal population codes for space: grid cells outperform place cells. ( 0,830258243845887 )
Int J Health Geogr - Does context matter for the relationship between deprivation and all-cause mortality? The West vs. the rest of Scotland. ( 0,829723258272129 )
Int J Health Geogr - Mapping HIV clustering: a strategy for identifying populations at high risk of HIV infection in sub-Saharan Africa. ( 0,829097655709619 )
Int J Health Geogr - Ecological niche modelling of Hemipteran insects in Cameroon; the paradox of a vector-borne transmission for Mycobacterium ulcerans, the causative agent of Buruli ulcer. ( 0,826824759699107 )
Int J Health Geogr - A modified version of Moran's I. ( 0,824886334028706 )
Int J Health Geogr - A high resolution spatial population database of Somalia for disease risk mapping. ( 0,823591647934401 )
Int J Health Geogr - Nonparametric intensity bounds for the delineation of spatial clusters. ( 0,81671965389544 )
Int J Health Geogr - A spatial approach for the epidemiology of antibiotic use and resistance in community-based studies: the emergence of urban clusters of Escherichia coli quinolone resistance in Sao Paulo, Brasil. ( 0,816035430160774 )
Int J Health Geogr - Smart density: A more accurate method of measuring rural residential density for health-related research. ( 0,810858853920077 )
Int J Health Geogr - The effects of local street network characteristics on the positional accuracy of automated geocoding for geographic health studies. ( 0,807528916143586 )
Int J Health Geogr - Spatial distribution and cluster analysis of sexual risk behaviors reported by young men in Kisumu, Kenya. ( 0,80576040452898 )
Int J Health Geogr - Pathogenic landscapes: interactions between land, people, disease vectors, and their animal hosts. ( 0,803588649111678 )
Int J Health Geogr - Modeling the spatial distribution of Chagas disease vectors using environmental variables and people?s knowledge. ( 0,802589924385228 )
Spat Spatiotemporal Epidemiol - Prostate cancer incidence in light of the spatial distribution of another screening-detectable cancer. ( 0,801655127468306 )
Int J Health Geogr - Schistosomiasis transmission and environmental change: a spatio-temporal analysis in Porto de Galinhas, Pernambuco--Brazil. ( 0,799192662523261 )
Spat Spatiotemporal Epidemiol - How to choose geographical units in ecological studies: proposal and application to campylobacteriosis. ( 0,796741472609628 )
Int J Health Geogr - Spatial epidemiology of eastern equine encephalitis in Florida. ( 0,789737806903347 )
Int J Health Geogr - Modelling the variation of land surface temperature as determinant of risk of heat-related health events. ( 0,785916100231693 )
Int J Health Geogr - Hand, foot and mouth disease: spatiotemporal transmission and climate. ( 0,785801931015087 )
Int J Health Geogr - Enhancing spatial detection accuracy for syndromic surveillance with street level incidence data. ( 0,781696231754627 )
Int J Health Geogr - Including the urban heat island in spatial heat health risk assessment strategies: a case study for Birmingham, UK. ( 0,781102289265047 )
J Med Syst - A small-area study of environmental risk assessment of outdoor falls. ( 0,776461700732299 )
Int J Health Geogr - Racial differences in the built environment--body mass index relationship? A geospatial analysis of adolescents in urban neighborhoods. ( 0,766650742472247 )
Spat Spatiotemporal Epidemiol - Violent crime in San Antonio, Texas: an application of spatial epidemiological methods. ( 0,766205974087464 )
Int J Health Geogr - Spatial pattern of body mass index among adults in the diabetes study of Northern California (DISTANCE). ( 0,764190299267876 )
Int J Health Geogr - A ubiquitous method for street scale spatial data collection and analysis in challenging urban environments: mapping health risks using spatial video in Haiti. ( 0,761178573272434 )
Int J Health Geogr - Relevance of the type III error in epidemiological maps. ( 0,759352503452493 )
Int J Health Geogr - Diarrheal disease risk in rural Bangladesh decreases as tubewell density increases: a zero-inflated and geographically weighted analysis. ( 0,758152359620451 )
Int J Health Geogr - Is temperature the main cause of dengue rise in non-endemic countries? The case of Argentina. ( 0,755686277215078 )
Int J Health Geogr - Developing the atlas of cancer in Queensland: methodological issues. ( 0,751715851247926 )
Int J Health Geogr - Identification and location of hot and cold spots of treated prevalence of depression in Catalonia (Spain). ( 0,750438144976063 )
Int J Health Geogr - Retrospective space-time analysis of H5N1 Avian Influenza emergence in Thailand. ( 0,750157480205827 )
Int J Health Geogr - Outdoor air pollution, subtypes and severity of ischemic stroke--a small-area level ecological study. ( 0,748877925706587 )
Int J Health Geogr - Spatial patterns of fetal loss and infant death in an arsenic-affected area in Bangladesh. ( 0,745382111179592 )
Int J Health Geogr - Highways and outposts: economic development and health threats in the central Brazilian Amazon region. ( 0,744791110021969 )
Int J Health Geogr - Particulate air pollution and health inequalities: a Europe-wide ecological analysis. ( 0,743198004907084 )
Int J Health Geogr - A probabilistic sampling method (PSM) for estimating geographic distance to health services when only the region of residence is known. ( 0,742981225204584 )
Int J Health Geogr - Terra and Aqua satellites track tiger mosquito invasion: modelling the potential distribution of Aedes albopictus in north-eastern Italy. ( 0,742711564086352 )
Int J Health Geogr - Modeling spatial accessibility to parks: a national study. ( 0,742380564360891 )
Comput Biol Chem - DNA clustering and genome complexity. ( 0,74071123387583 )
Int J Health Geogr - Can a deprivation index be used legitimately over both urban and rural areas? ( 0,736016084436927 )
Int J Health Geogr - Global spatiotemporal and genetic footprint of the H5N1 avian influenza virus. ( 0,735499551497793 )
Spat Spatiotemporal Epidemiol - Spatio-temporal epidemiology: principles and opportunities. ( 0,732244325270841 )
Int J Health Geogr - The modifiable areal unit problem (MAUP) in the relationship between exposure to NO2 and respiratory health. ( 0,727714829320244 )
Int J Health Geogr - Geographical variation of Crohn's disease residual incidence in the Province of Quebec, Canada. ( 0,724183916675543 )
Int J Health Geogr - How do changes to the built environment influence walking behaviors? A longitudinal study within a university campus in Hong Kong. ( 0,723811008974219 )
Int J Health Geogr - Performance map of a cluster detection test using extended power. ( 0,723717252037465 )
Int J Health Geogr - A power comparison of generalized additive models and the spatial scan statistic in a case-control setting. ( 0,721987797022657 )
Int J Health Geogr - Feasibility and utility of mapping disease risk at the neighbourhood level within a Canadian public health unit: an ecological study. ( 0,713802836834436 )
Int J Health Geogr - Urban sprawl, obesity, and cancer mortality in the United States: cross-sectional analysis and methodological challenges. ( 0,713095442903555 )
J Chem Inf Model - Aggregation properties of a polymeric anticancer therapeutic: a coarse-grained modeling study. ( 0,711174912824629 )
Geospat Health - Redefining climate regions in the United States of America using satellite remote sensing and machine learning for public health applications. ( 0,710756382801978 )
Spat Spatiotemporal Epidemiol - Risk factor modelling of the spatio-temporal patterns of highly pathogenic avian influenza (HPAIV) H5N1: a review. ( 0,708048675990228 )
Int J Health Geogr - A novel tool for assessing and summarizing the built environment. ( 0,705765392368024 )
Int J Health Geogr - Spatial-explicit modeling of social vulnerability to malaria in East Africa. ( 0,701503013840449 )
Int J Health Geogr - An open source software for fast grid-based data-mining in spatial epidemiology (FGBASE). ( 0,69902832451443 )
Int J Health Geogr - Proximity of public elementary schools to major roads in Canadian urban areas. ( 0,698085880523109 )
Spat Spatiotemporal Epidemiol - Spatial and statistical methodologies to determine the distribution of dengue in Brazilian municipalities and relate incidence with the Health Vulnerability Index. ( 0,697885395431967 )
Spat Spatiotemporal Epidemiol - Spatial error in geocoding physician location data from the AMA Physician Masterfile: implications for spatial accessibility analysis. ( 0,696553451628532 )
Int J Health Geogr - Statistical air quality predictions for public health surveillance: evaluation and generation of county level metrics of PM2.5 for the environmental public health tracking network. ( 0,693856631942804 )
Int J Health Geogr - International variation in neighborhood walkability, transit, and recreation environments using geographic information systems: the IPEN adult study. ( 0,693708568463199 )
Spat Spatiotemporal Epidemiol - Spatial patterns of human papillomavirus-associated cancers within the state of Minnesota, 1998-2007. ( 0,692668408661128 )
Int J Health Geogr - Analysis of matched geographical areas to study potential links between environmental exposure to oil refineries and non-Hodgkin lymphoma mortality in Spain. ( 0,689902315733254 )
Int J Health Geogr - Potential corridors and barriers for plague spread in Central Asia. ( 0,687133453315873 )
Int J Health Geogr - The spatial distribution of esophageal and gastric cancer in Caspian region of Iran: an ecological analysis of diet and socio-economic influences. ( 0,68655544639526 )
Spat Spatiotemporal Epidemiol - Measuring the spatial accuracy of the spatial scan statistic. ( 0,686242452774602 )
Int J Health Geogr - Mapping heatwave health risk at the community level for public health action. ( 0,685166497779587 )
Spat Spatiotemporal Epidemiol - Using geographical information systems and cartograms as a health service quality improvement tool. ( 0,682518708116253 )
Spat Spatiotemporal Epidemiol - Generalizing the spatial relative risk function. ( 0,678284191504155 )
Spat Spatiotemporal Epidemiol - Racial residential segregation impacts on low birth weight using improved neighborhood boundary definitions. ( 0,678195410618025 )
Int J Health Geogr - Associations of supermarket accessibility with obesity and fruit and vegetable consumption in the conterminous United States. ( 0,677811311913013 )
Spat Spatiotemporal Epidemiol - Using geospatial technologies to explore activity-based retail food environments. ( 0,672379529279133 )
Spat Spatiotemporal Epidemiol - A spatial measure of neighborhood level racial isolation applied to low birthweight, preterm birth, and birthweight in North Carolina. ( 0,67172465480807 )
Int J Health Geogr - The road most travelled: the geographic distribution of road traffic injuries in England. ( 0,669656542717877 )
Int J Health Geogr - Data-driven inference for the spatial scan statistic. ( 0,665991282226678 )
Int J Health Geogr - Analyzing spatial aggregation error in statistical models of late-stage cancer risk: a Monte Carlo simulation approach. ( 0,665832151303774 )
Spat Spatiotemporal Epidemiol - On the effect of diagnostic misclassification bias on the observed spatial pattern in regional count data--a case study using West Nile virus mortality data from Ontario, 2005. ( 0,658660694836772 )
Int J Health Geogr - An ecological study on childhood autism. ( 0,658173339464948 )
Int J Health Geogr - Zoom in at African country level: potential climate induced changes in areas of suitability for survival of malaria vectors. ( 0,658009041597303 )
J Chem Inf Model - Electron density distribution in endohedral complexes of fullerene C60, calculated based on the Gauss law. ( 0,657883083796227 )
Int J Health Geogr - An application of the edge effect in measuring accessibility to multiple food retailer types in southwestern Ontario, Canada. ( 0,656331287183842 )
Int J Health Geogr - Older adults' transportation walking: a cross-sectional study on the cumulative influence of physical environmental factors. ( 0,655700547552272 )
Int J Health Geogr - Characterizing the interface between wild ducks and poultry to evaluate the potential of transmission of avian pathogens. ( 0,653576388659033 )
J Telemed Telecare - Inexpensive, realtime tele-ultrasound using a commercial, web-based video streaming device. ( 0,653011002774928 )
Int J Health Geogr - Creating 'obesogenic realities'; do our methodological choices make a difference when measuring the food environment? ( 0,651461937876966 )
Sci Data - A comprehensive database of the geographic spread of past human Ebola outbreaks. ( 0,651060763742502 )
Int J Health Geogr - Utilizing spatial statistics to identify cancer hot spots: a surveillance strategy to inform community-engaged outreach efforts. ( 0,64955975107922 )