J Integr Bioinform - Analysis and construction of pathogenicity island regulatory pathways in Salmonella enterica serovar Typhi.

Tópicos

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Resumo

Signal transduction through protein-protein interactions and protein modifications are the main mechanisms controlling many biological processes. Here we described the implementation of MedScan information extraction technology and Pathway Studio software (Ariadne Genomics Inc.) to create a Salmonella specific molecular interaction database. Using the database, we have constructed several signal transduction pathways in Salmonella enterica serovar Typhi which causes Typhoid Fever, a major health threat especially in developing countries. S. Typhi has several pathogenicity islands that control rapid switching between different phenotypes including adhesion and colonization, invasion, intracellular survival, proliferation, and biofilm formation in response to environmental changes. Understanding of the detailed mechanism for S. Typhi survival in host cells is necessary for development of efficient detection and treatment of this pathogen. The constructed pathways were validated using publically available gene expression microarray data for Salmonella.

Resumo Limpo

signal transduct proteinprotein interact protein modif main mechan control mani biolog process describ implement medscan inform extract technolog pathway studio softwar ariadn genom inc creat salmonella specif molecular interact databas use databas construct sever signal transduct pathway salmonella enterica serovar typhi caus typhoid fever major health threat especi develop countri s typhi sever pathogen island control rapid switch differ phenotyp includ adhes colon invas intracellular surviv prolifer biofilm format respons environment chang understand detail mechan s typhi surviv host cell necessari develop effici detect treatment pathogen construct pathway valid use public avail gene express microarray data salmonella

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