J Integr Bioinform - Integrating phenotypic data for depression.

Tópicos

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Resumo

The golden era of molecular genetic research brings about an explosion of phenotypic, genotypic and sequencing data. Building on the common aims to exploit understanding of human diseases, it also opens up an opportunity for scientific communities to share and combine research data. Genome-wide association studies (GWAS) have been widely used to locate genetic variants, which are susceptible for common diseases. In the field of medical genetics, many international collaborative consortiums have been established to conduct meta-analyses of GWAS results and to combine large genotypic data sets to perform mega genetic analyses. Having an integrated phenotype database is significant for exploiting the full potential of extensive genotypic data. In this paper, we aim to share our experience gained from integrating four heterogeneous sets of major depression phenotypic data onto the MySQL platform. These data sets constitute clinical data which had been gathered for various genetic studies for the past decade. We also highlight in this report some generic data handling techniques, the costs and benefits regarding the use of integrated phenotype database within our own institution and under the consortium framework.

Resumo Limpo

golden era molecular genet research bring explos phenotyp genotyp sequenc data build common aim exploit understand human diseas also open opportun scientif communiti share combin research data genomewid associ studi gwas wide use locat genet variant suscept common diseas field medic genet mani intern collabor consortium establish conduct metaanalys gwas result combin larg genotyp data set perform mega genet analys integr phenotyp databas signific exploit full potenti extens genotyp data paper aim share experi gain integr four heterogen set major depress phenotyp data onto mysql platform data set constitut clinic data gather various genet studi past decad also highlight report generic data handl techniqu cost benefit regard use integr phenotyp databas within institut consortium framework

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