J Integr Bioinform - miReg: a resource for microRNA regulation.

Tópicos

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{ import(1318) role(1303) understand(862) }
{ general(901) number(790) one(736) }
{ data(3963) clinic(1234) research(1004) }
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{ group(2977) signific(1463) compar(1072) }
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{ structur(1116) can(940) graph(676) }
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Resumo

MicroRNAs (miRNAs/miRs) are important cellular components that regulate gene expression at posttranscriptional level. Various upstream components regulate miR expression and any deregulation causes disease conditions. Therefore, understanding of miR regulatory network both at upstream and downstream level is crucial and a resource on this aspect will be helpful. Currently available miR databases are mostly related to downstream targets, sequences, or diseases. But as of now, no database is available that provides a complete picture of miR regulation in a specific condition. Our miR regulation web resource (miReg) is a manually curated one that represents validated upstream regulators (transcription factor, drug, physical, and chemical) along with downstream targets, associated biological process, experimental condition or disease state, up or down regulation of the miR in that condition, and corresponding PubMed references in a graphical and user friendly manner, browseable through 5 browsing options. We have presented exact facts that have been described in the corresponding literature in relation to a given miR, whether it's a feed-back/feed-forward loop or inhibition/activation. Moreover we have given various links to integrate data and to get a complete picture on any miR listed. Current version (Version 1.0) of miReg contains 47 important human miRs with 295 relations using 190 absolute references. We have also provided an example on usefulness of miReg to establish signalling pathways involved in cardiomyopathy. We believe that miReg will be an essential miRNA knowledge base to research community, with its continuous upgrade and data enrichment. This HTML based miReg can be accessed from: www.iioab-mireg.webs.com or www.iioab.webs.com/mireg.htm.

Resumo Limpo

microrna mirnasmir import cellular compon regul gene express posttranscript level various upstream compon regul mir express deregul caus diseas condit therefor understand mir regulatori network upstream downstream level crucial resourc aspect will help current avail mir databas most relat downstream target sequenc diseas now databas avail provid complet pictur mir regul specif condit mir regul web resourc mireg manual curat one repres valid upstream regul transcript factor drug physic chemic along downstream target associ biolog process experiment condit diseas state regul mir condit correspond pubm refer graphic user friend manner browseabl brows option present exact fact describ correspond literatur relat given mir whether feedbackfeedforward loop inhibitionactiv moreov given various link integr data get complet pictur mir list current version version mireg contain import human mir relat use absolut refer also provid exampl use mireg establish signal pathway involv cardiomyopathi believ mireg will essenti mirna knowledg base research communiti continu upgrad data enrich html base mireg can access wwwiioabmiregwebscom wwwiioabwebscommireghtm

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