BMC Med Inform Decis Mak - PKreport: report generation for checking population pharmacokinetic model assumptions.

Tópicos

{ data(1714) softwar(1251) tool(1186) }
{ visual(1396) interact(850) tool(830) }
{ estim(2440) model(1874) function(577) }
{ structur(1116) can(940) graph(676) }
{ care(1570) inform(1187) nurs(1089) }
{ system(1976) rule(880) can(841) }
{ network(2748) neural(1063) input(814) }
{ model(2656) set(1616) predict(1553) }
{ learn(2355) train(1041) set(1003) }
{ method(1557) propos(1049) approach(1037) }
{ search(2224) databas(1162) retriev(909) }
{ import(1318) role(1303) understand(862) }
{ inform(2794) health(2639) internet(1427) }
{ design(1359) user(1324) use(1319) }
{ perform(999) metric(946) measur(919) }
{ patient(1821) servic(1111) care(1106) }
{ result(1111) use(1088) new(759) }
{ take(945) account(800) differ(722) }
{ extract(1171) text(1153) clinic(932) }
{ control(1307) perform(991) simul(935) }
{ general(901) number(790) one(736) }
{ featur(1941) imag(1645) propos(1176) }
{ case(1353) use(1143) diagnosi(1136) }
{ record(1888) medic(1808) patient(1693) }
{ state(1844) use(1261) util(961) }
{ patient(2837) hospit(1953) medic(668) }
{ data(2317) use(1299) case(1017) }
{ sampl(1606) size(1419) use(1276) }
{ gene(2352) biolog(1181) express(1162) }
{ first(2504) two(1366) second(1323) }
{ analysi(2126) use(1163) compon(1037) }
{ survey(1388) particip(1329) question(1065) }
{ method(2212) result(1239) propos(1039) }
{ detect(2391) sensit(1101) algorithm(908) }
{ model(3404) distribut(989) bayesian(671) }
{ can(774) often(719) complex(702) }
{ imag(1947) propos(1133) code(1026) }
{ data(1737) use(1416) pattern(1282) }
{ measur(2081) correl(1212) valu(896) }
{ imag(1057) registr(996) error(939) }
{ bind(1733) structur(1185) ligand(1036) }
{ sequenc(1873) structur(1644) protein(1328) }
{ method(1219) similar(1157) match(930) }
{ featur(3375) classif(2383) classifi(1994) }
{ imag(2830) propos(1344) filter(1198) }
{ imag(2675) segment(2577) method(1081) }
{ patient(2315) diseas(1263) diabet(1191) }
{ studi(2440) review(1878) systemat(933) }
{ motion(1329) object(1292) video(1091) }
{ assess(1506) score(1403) qualiti(1306) }
{ treatment(1704) effect(941) patient(846) }
{ surgeri(1148) surgic(1085) robot(1054) }
{ framework(1458) process(801) describ(734) }
{ problem(2511) optim(1539) algorithm(950) }
{ error(1145) method(1030) estim(1020) }
{ chang(1828) time(1643) increas(1301) }
{ concept(1167) ontolog(924) domain(897) }
{ clinic(1479) use(1117) guidelin(835) }
{ algorithm(1844) comput(1787) effici(935) }
{ model(2220) cell(1177) simul(1124) }
{ method(984) reconstruct(947) comput(926) }
{ howev(809) still(633) remain(590) }
{ data(3963) clinic(1234) research(1004) }
{ studi(1410) differ(1259) use(1210) }
{ risk(3053) factor(974) diseas(938) }
{ research(1085) discuss(1038) issu(1018) }
{ system(1050) medic(1026) inform(1018) }
{ model(2341) predict(2261) use(1141) }
{ compound(1573) activ(1297) structur(1058) }
{ perform(1367) use(1326) method(1137) }
{ studi(1119) effect(1106) posit(819) }
{ blood(1257) pressur(1144) flow(957) }
{ spatial(1525) area(1432) region(1030) }
{ health(3367) inform(1360) care(1135) }
{ model(3480) simul(1196) paramet(876) }
{ monitor(1329) mobil(1314) devic(1160) }
{ ehr(2073) health(1662) electron(1139) }
{ research(1218) medic(880) student(794) }
{ age(1611) year(1155) adult(843) }
{ medic(1828) order(1363) alert(1069) }
{ signal(2180) analysi(812) frequenc(800) }
{ cost(1906) reduc(1198) effect(832) }
{ group(2977) signific(1463) compar(1072) }
{ data(3008) multipl(1320) sourc(1022) }
{ intervent(3218) particip(2042) group(1664) }
{ activ(1138) subject(705) human(624) }
{ time(1939) patient(1703) rate(768) }
{ use(2086) technolog(871) perceiv(783) }
{ can(981) present(881) function(850) }
{ health(1844) social(1437) communiti(874) }
{ high(1669) rate(1365) level(1280) }
{ cancer(2502) breast(956) screen(824) }
{ use(976) code(926) identifi(902) }
{ use(1733) differ(960) four(931) }
{ drug(1928) target(777) effect(648) }
{ implement(1333) system(1263) develop(1122) }
{ decis(3086) make(1611) patient(1517) }
{ process(1125) use(805) approach(778) }
{ activ(1452) weight(1219) physic(1104) }
{ method(1969) cluster(1462) data(1082) }

Resumo

CKGROUND: Graphics play an important and unique role in population pharmacokinetic (PopPK) model building by exploring hidden structure among data before modeling, evaluating model fit, and validating results after modeling.RESULTS: The work described in this paper is about a new R package called PKreport, which is able to generate a collection of plots and statistics for testing model assumptions, visualizing data and diagnosing models. The metric system is utilized as the currency for communicating between data sets and the package to generate special-purpose plots. It provides ways to match output from diverse software such as NONMEM, Monolix, R nlme package, etc. The package is implemented with S4 class hierarchy, and offers an efficient way to access the output from NONMEM 7. The final reports take advantage of the web browser as user interface to manage and visualize plots.CONCLUSIONS: PKreport provides 1) a flexible and efficient R class to store and retrieve NONMEM 7 output, 2) automate plots for users to visualize data and models, 3) automatically generated R scripts that are used to create the plots; 4) an archive-oriented management tool for users to store, retrieve and modify figures, 5) high-quality graphs based on the R packages, lattice and ggplot2. The general architecture, running environment and statistical methods can be readily extended with R class hierarchy. PKreport is free to download at http://cran.r-project.org/web/packages/PKreport/index.html.

Resumo Limpo

ckground graphic play import uniqu role popul pharmacokinet poppk model build explor hidden structur among data model evalu model fit valid result modelingresult work describ paper new r packag call pkreport abl generat collect plot statist test model assumpt visual data diagnos model metric system util currenc communic data set packag generat specialpurpos plot provid way match output divers softwar nonmem monolix r nlme packag etc packag implement s class hierarchi offer effici way access output nonmem final report take advantag web browser user interfac manag visual plotsconclus pkreport provid flexibl effici r class store retriev nonmem output autom plot user visual data model automat generat r script use creat plot archiveori manag tool user store retriev modifi figur highqual graph base r packag lattic ggplot general architectur run environ statist method can readili extend r class hierarchi pkreport free download httpcranrprojectorgwebpackagespkreportindexhtml

Resumos Similares

Curr Protoc Bioinformatics - APPENDIX 1B Common File Formats. ( 0,730436646932183 )
Curr Protoc Bioinformatics - Using PeptideAtlas, SRMAtlas, and PASSEL: Comprehensive Resources for Discovery and Targeted Proteomics. ( 0,726387994811519 )
Brief. Bioinformatics - Software applications for flux balance analysis. ( 0,721742602667252 )
J Chem Inf Model - JGromacs: a Java package for analyzing protein simulations. ( 0,720841739098637 )
Methods Inf Med - MITK diffusion imaging. ( 0,716899462342566 )
J Chem Inf Model - DockoMatic 2.0: high throughput inverse virtual screening and homology modeling. ( 0,713115616861223 )
Comput. Biol. Med. - Trans3D: a free tool for dynamical visualization of EEG activity transmission in the brain. ( 0,710572980425572 )
J Chem Inf Model - ThermoData Engine (TDE): software implementation of the dynamic data evaluation concept. 9. Extensible thermodynamic constraints for pure compounds and new model developments. ( 0,708104668235839 )
J Integr Bioinform - A flexible statistics web processing service--added value for information systems for experiment data. ( 0,69755240923547 )
BMC Med Inform Decis Mak - Clinical software development for the Web: lessons learned from the BOADICEA project. ( 0,696344645326137 )
J Clin Monit Comput - Integrating Arden-Syntax-based clinical decision support with extended presentation formats into a commercial patient data management system. ( 0,686138190185757 )
Brief. Bioinformatics - Architecture for interoperable software in biology. ( 0,684163887873568 )
J Med Syst - A data types profile suitable for use with ISO EN 13606. ( 0,68068032548303 )
Curr Protoc Bioinformatics - Using EMBL-EBI Services via Web Interface and Programmatically via Web Services. ( 0,679647258449488 )
J Chem Inf Model - iBIOMES: managing and sharing biomolecular simulation data in a distributed environment. ( 0,676261792838617 )
IEEE J Biomed Health Inform - Multimodality Neurological Data Visualization with Multi-VOI Based DTI Fiber Dynamic Integration. ( 0,676239477932319 )
Comput. Biol. Med. - IVUSAngio tool: a publicly available software for fast and accurate 3D reconstruction of coronary arteries. ( 0,674965186769469 )
J Chem Inf Model - CYANOS: a data management system for natural product drug discovery efforts using cultured microorganisms. ( 0,673133051546998 )
AMIA Annu Symp Proc - ARX--A Comprehensive Tool for Anonymizing Biomedical Data. ( 0,67235599040473 )
Comput. Biol. Med. - NGSPE: A pipeline for end-to-end analysis of DNA sequencing data and comparison between different platforms. ( 0,670517445474396 )
IEEE Trans Vis Comput Graph - A Survey of Software Frameworks for Cluster-Based Large High-Resolution Displays. ( 0,667273974089264 )
Comput Methods Programs Biomed - SAS macro programs for geographically weighted generalized linear modeling with spatial point data: applications to health research. ( 0,666144384695431 )
Comput Methods Programs Biomed - Using off-the-shelf tools for terabyte-scale waveform recording in intensive care: computer system design, database description and lessons learned. ( 0,662120386005614 )
Int J Health Geogr - Open-Source web-based Geographical Information System for health exposure assessment. ( 0,6587870511508 )
Comput Methods Programs Biomed - An open source tool for heart rate variability spectral analysis. ( 0,658471270772637 )
Comput Methods Programs Biomed - Raw data extraction from electrocardiograms with Portable Document Format. ( 0,653425481772904 )
Comput Methods Programs Biomed - Biomechanical ToolKit: Open-source framework to visualize and process biomechanical data. ( 0,648860488636491 )
J Med Syst - LAS: a software platform to support oncological data management. ( 0,6449371869829 )
Comput. Biol. Med. - POTAMOS mass spectrometry calculator: computer aided mass spectrometry to the post-translational modifications of proteins. A focus on histones. ( 0,644329784367063 )
J Biomed Inform - Cloud-based bioinformatics workflow platform for large-scale next-generation sequencing analyses. ( 0,643664307189145 )
Comput Methods Programs Biomed - Software for quantitative analysis of radiotherapy: overview, requirement analysis and design solutions. ( 0,642618396439568 )
Int J Comput Assist Radiol Surg - The Medical Imaging Interaction Toolkit: challenges and advances : 10 years of open-source development. ( 0,642351931429806 )
Brief. Bioinformatics - Bioinformatics tools and database resources for systems genetics analysis in mice--a short review and an evaluation of future needs. ( 0,642057234359673 )
Int J Comput Assist Radiol Surg - Development and implementation of an integrated mobile situational awareness iPhone application VigiVU? at an academic medical center. ( 0,639466705636347 )
BMC Med Inform Decis Mak - Text data extraction for a prospective, research-focused data mart: implementation and validation. ( 0,637891934104341 )
Comput Methods Programs Biomed - BioDoser: improved dose-estimation software for biological radiation dosimetry. ( 0,637477372568986 )
Methods Inf Med - Supporting translational research on inherited cardiomyopathies through information technology. ( 0,636273817480994 )
Comput. Biol. Med. - VAAPA: a web platform for visualization and analysis of alternative polyadenylation. ( 0,63599648822911 )
Appl Clin Inform - Design and multicentric implementation of a generic software architecture for patient recruitment systems re-using existing HIS tools and routine patient data. ( 0,635638705110398 )
J Biomed Inform - Modular design, application architecture, and usage of a self-service model for enterprise data delivery: the Duke Enterprise Data Unified Content Explorer (DEDUCE). ( 0,630112704410156 )
J Chem Inf Model - ChemDoodle 6.0. ( 0,622683854179414 )
BMC Med Inform Decis Mak - XML-BSPM: an XML format for storing Body Surface Potential Map recordings. ( 0,621427393098716 )
J Am Med Inform Assoc - Identifying clinical/translational research cohorts: ascertainment via querying an integrated multi-source database. ( 0,618217544544018 )
J Chem Inf Model - Integrated project views: decision support platform for drug discovery project teams. ( 0,614289552008356 )
IEEE Trans Vis Comput Graph - Hybrid Rendering with Scheduling under Uncertainty. ( 0,612911282012879 )
Brief. Bioinformatics - Web scraping technologies in an API world. ( 0,612853492269289 )
Int J Comput Assist Radiol Surg - Neurosurgical simulation by interactive computer graphics on iPad. ( 0,612022688266755 )
Comput Methods Programs Biomed - Online analysis of in vitro resistance to antimalarial drugs through nonlinear regression. ( 0,611131192755234 )
Int J Med Inform - A review of ECG storage formats. ( 0,609803134806007 )
Med Biol Eng Comput - Towards a flexible middleware for context-aware pervasive and wearable systems. ( 0,609212071267291 )
J Chem Inf Model - Intuitive patent Markush structure visualization tool for medicinal chemists. ( 0,608693779402632 )
J Integr Bioinform - Bioinformatics strategies in life sciences: from data processing and data warehousing to biological knowledge extraction. ( 0,608187142992362 )
Methods Inf Med - Enabling GeneHunter as a grid service: a case study for implementing analytical services in biomedical grids. ( 0,607600265134719 )
AMIA Annu Symp Proc - The SHARPn project on secondary use of Electronic Medical Record data: progress, plans, and possibilities. ( 0,607300164903574 )
J Med Syst - Development and evaluation of tools for measuring the quality of experience (QoE) in mHealth applications. ( 0,605205364380142 )
J Chem Inf Model - A general sequence processing and analysis program for protein engineering. ( 0,604931117187478 )
J Chem Inf Model - JACOB: a dynamic database for computational chemistry benchmarking. ( 0,603843111306649 )
J Biomed Inform - WebBioBank: a new platform for integrating clinical forms and shared neurosignal analyses to support multi-centre studies in Parkinson's Disease. ( 0,602261179387197 )
J. Med. Internet Res. - Making sense of mobile health data: an open architecture to improve individual- and population-level health. ( 0,602173830407164 )
J Am Med Inform Assoc - An optimized web-based approach for collaborative stereoscopic medical visualization. ( 0,602132926784352 )
J Integr Bioinform - BacillOndex: an integrated data resource for systems and synthetic biology. ( 0,600648600400139 )
Int J Health Geogr - Neighborhood deprivation, vehicle ownership, and potential spatial access to a variety of fruits and vegetables in a large rural area in Texas. ( 0,599588487743323 )
J Chem Inf Model - AsteriX: a Web server to automatically extract ligand coordinates from figures in PDF articles. ( 0,599438699221271 )
Comput Methods Programs Biomed - PKSolver: An add-in program for pharmacokinetic and pharmacodynamic data analysis in Microsoft Excel. ( 0,598944870427946 )
J Chem Inf Model - Fragment-based docking: development of the CHARMMing Web user interface as a platform for computer-aided drug design. ( 0,598744544121846 )
J Chem Inf Model - Atomdroid: a computational chemistry tool for mobile platforms. ( 0,597437741010117 )
J Chem Inf Model - CycloPs: generating virtual libraries of cyclized and constrained peptides including nonnatural amino acids. ( 0,595999176706157 )
J Med Syst - COSARA: integrated service platform for infection surveillance and antibiotic management in the ICU. ( 0,59515654122277 )
Brief. Bioinformatics - The UCSC genome browser and associated tools. ( 0,594892467937855 )
Health Informatics J - Implementation of integrated heterogeneous electronic electrocardiography data into Maharaj Nakorn Chiang Mai Hospital Information System. ( 0,594614270503489 )
Int J Health Geogr - Displaying R spatial statistics on Google dynamic maps with web applications created by Rwui. ( 0,593508741490156 )
J Chem Inf Model - hERG me out. ( 0,593428288440627 )
Methods Inf Med - Missing semantic annotation in databases. The root cause for data integration and migration problems in information systems. ( 0,592615479460166 )
J Am Med Inform Assoc - Bionimbus: a cloud for managing, analyzing and sharing large genomics datasets. ( 0,591809506890335 )
J Chem Inf Model - 3-D QSAutogrid/R: an alternative procedure to build 3-D QSAR models. Methodologies and applications. ( 0,59174865237134 )
Comput Methods Programs Biomed - jSIPRO - analysis tool for magnetic resonance spectroscopic imaging. ( 0,591690049037533 )
J Integr Bioinform - Tracking T and B cells from two-photon microscopy imaging using constrained SMC clusters. ( 0,591037183318172 )
AMIA Annu Symp Proc - eEvidence: Information Seeking Support for Evidence-based Practice: An Implementation Case Study. ( 0,588752437410839 )
J Am Med Inform Assoc - MilxXplore: a web-based system to explore large imaging datasets. ( 0,588473388555702 )
AMIA Annu Symp Proc - ASLForm: an adaptive self learning medical form generating system. ( 0,588074294501573 )
J Chem Inf Model - PROLIX: rapid mining of protein-ligand interactions in large crystal structure databases. ( 0,587871422441691 )
J Chem Inf Model - ZINC: a free tool to discover chemistry for biology. ( 0,587568762953622 )
J Chem Inf Model - ChemCalc: a building block for tomorrow's chemical infrastructure. ( 0,58704862420954 )
J Biomed Inform - The Analytic Information Warehouse (AIW): a platform for analytics using electronic health record data. ( 0,586993221143137 )
IEEE J Biomed Health Inform - An interoperable system for automated diagnosis of cardiac abnormalities from electrocardiogram data. ( 0,586317145035188 )
J Am Med Inform Assoc - Enabling collaborative research using the Biomedical Informatics Research Network (BIRN). ( 0,585955828136421 )
Brief. Bioinformatics - RNA tertiary structure prediction with ModeRNA. ( 0,584535759697468 )
J Med Syst - A user-centered, object-oriented methodology for developing Health Information Systems: a Clinical Information System (CIS) example. ( 0,581725789946085 )
Med Biol Eng Comput - FieldML, a proposed open standard for the Physiome project for mathematical model representation. ( 0,578823279771881 )
J Integr Bioinform - UBioLab: a web-laboratory for ubiquitous in-silico experiments. ( 0,577579248917307 )
Comput Methods Programs Biomed - Social Web mining and exploitation for serious applications: Technosocial Predictive Analytics and related technologies for public health, environmental and national security surveillance. ( 0,576307830594263 )
J Digit Imaging - Development and evaluation of a low-cost and high-capacity DICOM image data storage system for research. ( 0,576138473006806 )
Comput Methods Programs Biomed - Warehousing re-annotated cancer genes for biomarker meta-analysis. ( 0,572044467762865 )
J Am Med Inform Assoc - Enabling distributed electronic research data collection for a rural Appalachian tobacco cessation study. ( 0,57108904191773 )
J. Comput. Biol. - DrML: probabilistic modeling of gene duplications. ( 0,570445114248825 )
Comput Methods Programs Biomed - A web application for follow-up of results from a mobile device test battery for Parkinson's disease patients. ( 0,569477559472756 )
BMC Med Inform Decis Mak - Applying representational state transfer (REST) architecture to archetype-based electronic health record systems. ( 0,56848218203264 )
Brief. Bioinformatics - The NGS WikiBook: a dynamic collaborative online training effort with long-term sustainability. ( 0,567566997071672 )
Methods Inf Med - The integration of the risk management process with the lifecycle of medical device software. ( 0,566629487921215 )
Appl Clin Inform - An information retrieval system for computerized patient records in the context of a daily hospital practice: the example of the L?on B?rard Cancer Center (France). ( 0,566543550946013 )