J. Comput. Biol. - RNA partial degradation problem: motivation, complexity, algorithm.

Tópicos

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{ method(2212) result(1239) propos(1039) }

Resumo

Studies conducted during the last decade unexpectedly revealed several new biological functions of RNA molecules. The involvement of RNA in many complex processes requires highly effective systems controlling its accumulation. In this context, the mechanisms of degradation appear as one of the most important factors influencing RNA activity. Here, we present our first attempt to describe the RNA degradation process using bioinformatics methods. Based on the obtained data, we propose a formulation of a new problem, called RNA Partial Degradation Problem (RNA PDP) and the algorithm that is capable of reconstructing an RNA molecule using the results of biochemical analysis of its degradation. In addition, we present the results of biochemical experiments and computational tests.

Resumo Limpo

studi conduct last decad unexpect reveal sever new biolog function rna molecul involv rna mani complex process requir high effect system control accumul context mechan degrad appear one import factor influenc rna activ present first attempt describ rna degrad process use bioinformat method base obtain data propos formul new problem call rna partial degrad problem rna pdp algorithm capabl reconstruct rna molecul use result biochem analysi degrad addit present result biochem experi comput test

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