J. Comput. Biol. - Expectation-maximization algorithm for determining natural selection of Y-linked genes through two-sex branching processes.

Tópicos

{ model(3404) distribut(989) bayesian(671) }
{ gene(2352) biolog(1181) express(1162) }
{ problem(2511) optim(1539) algorithm(950) }
{ age(1611) year(1155) adult(843) }
{ import(1318) role(1303) understand(862) }
{ model(2341) predict(2261) use(1141) }
{ state(1844) use(1261) util(961) }
{ data(2317) use(1299) case(1017) }
{ sampl(1606) size(1419) use(1276) }
{ method(1219) similar(1157) match(930) }
{ assess(1506) score(1403) qualiti(1306) }
{ framework(1458) process(801) describ(734) }
{ general(901) number(790) one(736) }
{ medic(1828) order(1363) alert(1069) }
{ decis(3086) make(1611) patient(1517) }
{ sequenc(1873) structur(1644) protein(1328) }
{ algorithm(1844) comput(1787) effici(935) }
{ extract(1171) text(1153) clinic(932) }
{ control(1307) perform(991) simul(935) }
{ method(984) reconstruct(947) comput(926) }
{ case(1353) use(1143) diagnosi(1136) }
{ studi(1119) effect(1106) posit(819) }
{ monitor(1329) mobil(1314) devic(1160) }
{ model(2656) set(1616) predict(1553) }
{ use(2086) technolog(871) perceiv(783) }
{ structur(1116) can(940) graph(676) }
{ cancer(2502) breast(956) screen(824) }
{ estim(2440) model(1874) function(577) }
{ process(1125) use(805) approach(778) }
{ activ(1452) weight(1219) physic(1104) }
{ detect(2391) sensit(1101) algorithm(908) }
{ can(774) often(719) complex(702) }
{ imag(1947) propos(1133) code(1026) }
{ data(1737) use(1416) pattern(1282) }
{ inform(2794) health(2639) internet(1427) }
{ system(1976) rule(880) can(841) }
{ measur(2081) correl(1212) valu(896) }
{ imag(1057) registr(996) error(939) }
{ bind(1733) structur(1185) ligand(1036) }
{ featur(3375) classif(2383) classifi(1994) }
{ imag(2830) propos(1344) filter(1198) }
{ network(2748) neural(1063) input(814) }
{ imag(2675) segment(2577) method(1081) }
{ patient(2315) diseas(1263) diabet(1191) }
{ take(945) account(800) differ(722) }
{ studi(2440) review(1878) systemat(933) }
{ motion(1329) object(1292) video(1091) }
{ treatment(1704) effect(941) patient(846) }
{ surgeri(1148) surgic(1085) robot(1054) }
{ error(1145) method(1030) estim(1020) }
{ chang(1828) time(1643) increas(1301) }
{ learn(2355) train(1041) set(1003) }
{ concept(1167) ontolog(924) domain(897) }
{ clinic(1479) use(1117) guidelin(835) }
{ method(1557) propos(1049) approach(1037) }
{ data(1714) softwar(1251) tool(1186) }
{ design(1359) user(1324) use(1319) }
{ model(2220) cell(1177) simul(1124) }
{ care(1570) inform(1187) nurs(1089) }
{ search(2224) databas(1162) retriev(909) }
{ featur(1941) imag(1645) propos(1176) }
{ howev(809) still(633) remain(590) }
{ data(3963) clinic(1234) research(1004) }
{ studi(1410) differ(1259) use(1210) }
{ risk(3053) factor(974) diseas(938) }
{ perform(999) metric(946) measur(919) }
{ research(1085) discuss(1038) issu(1018) }
{ system(1050) medic(1026) inform(1018) }
{ visual(1396) interact(850) tool(830) }
{ compound(1573) activ(1297) structur(1058) }
{ perform(1367) use(1326) method(1137) }
{ blood(1257) pressur(1144) flow(957) }
{ spatial(1525) area(1432) region(1030) }
{ record(1888) medic(1808) patient(1693) }
{ health(3367) inform(1360) care(1135) }
{ model(3480) simul(1196) paramet(876) }
{ ehr(2073) health(1662) electron(1139) }
{ research(1218) medic(880) student(794) }
{ patient(2837) hospit(1953) medic(668) }
{ signal(2180) analysi(812) frequenc(800) }
{ cost(1906) reduc(1198) effect(832) }
{ group(2977) signific(1463) compar(1072) }
{ data(3008) multipl(1320) sourc(1022) }
{ first(2504) two(1366) second(1323) }
{ intervent(3218) particip(2042) group(1664) }
{ activ(1138) subject(705) human(624) }
{ time(1939) patient(1703) rate(768) }
{ patient(1821) servic(1111) care(1106) }
{ can(981) present(881) function(850) }
{ analysi(2126) use(1163) compon(1037) }
{ health(1844) social(1437) communiti(874) }
{ high(1669) rate(1365) level(1280) }
{ use(976) code(926) identifi(902) }
{ use(1733) differ(960) four(931) }
{ drug(1928) target(777) effect(648) }
{ result(1111) use(1088) new(759) }
{ implement(1333) system(1263) develop(1122) }
{ survey(1388) particip(1329) question(1065) }
{ method(1969) cluster(1462) data(1082) }
{ method(2212) result(1239) propos(1039) }

Resumo

A two-dimensional bisexual branching process has recently been presented for the analysis of the generation-to-generation evolution of the number of carriers of a Y-linked gene. In this model, preference of females for males with a specific genetic characteristic is assumed to be determined by an allele of the gene. It has been shown that the behavior of this kind of Y-linked gene is strongly related to the reproduction law of each genotype. In practice, the corresponding offspring distributions are usually unknown, and it is necessary to develop their estimation theory in order to determine the natural selection of the gene. Here we deal with the estimation problem for the offspring distribution of each genotype of a Y-linked gene when the only observable data are each generation's total numbers of males of each genotype and of females. We set out the problem in a non parametric framework and obtain the maximum likelihood estimators of the offspring distributions using an expectation-maximization algorithm. From these estimators, we also derive the estimators for the reproduction mean of each genotype and forecast the distribution of the future population sizes. Finally, we check the accuracy of the algorithm by means of a simulation study.

Resumo Limpo

twodimension bisexu branch process recent present analysi generationtogener evolut number carrier ylink gene model prefer femal male specif genet characterist assum determin allel gene shown behavior kind ylink gene strong relat reproduct law genotyp practic correspond offspr distribut usual unknown necessari develop estim theori order determin natur select gene deal estim problem offspr distribut genotyp ylink gene observ data generat total number male genotyp femal set problem non parametr framework obtain maximum likelihood estim offspr distribut use expectationmaxim algorithm estim also deriv estim reproduct mean genotyp forecast distribut futur popul size final check accuraci algorithm mean simul studi

Resumos Similares

IEEE Trans Image Process - Bayesian robust principal component analysis. ( 0,79537002612762 )
Med Decis Making - Calibration of complex models through Bayesian evidence synthesis: a demonstration and tutorial. ( 0,794262701118175 )
Spat Spatiotemporal Epidemiol - Goodness-of-fit measures for individual-level models of infectious disease in a Bayesian framework. ( 0,785366033351513 )
Neural Comput - A semiparametric Bayesian model for detecting synchrony among multiple neurons. ( 0,773782048432595 )
Lifetime Data Anal - Bayesian semiparametric modeling for stochastic precedence, with applications in epidemiology and survival analysis. ( 0,771771347347147 )
IEEE Trans Pattern Anal Mach Intell - Are Gibbs-Type Priors the Most Natural Generalization of the Dirichlet Process? ( 0,76733275381075 )
Brief. Bioinformatics - The dilemma of choosing the ideal permutation strategy while estimating statistical significance of genome-wide enrichment. ( 0,766029302270713 )
Lifetime Data Anal - Bayesian nonparametric models for ranked set sampling. ( 0,757062630191115 )
J. Comput. Biol. - Characterizing the empirical distribution of prokaryotic genome n-mers in the presence of nullomers. ( 0,752412579182688 )
Res Synth Methods - A Bayesian nonparametric meta-analysis model. ( 0,749922272575247 )
IEEE Trans Image Process - Variational Bayesian method for Retinex. ( 0,749027772067156 )
J. Comput. Biol. - A spatial haplotype copying model with applications to genotype imputation. ( 0,738294059525106 )
Comput Methods Programs Biomed - The exponentiated exponential mixture and non-mixture cure rate model in the presence of covariates. ( 0,738166396856734 )
J. Comput. Biol. - Computational methods for a class of network models. ( 0,731153362163467 )
Comput Math Methods Med - Inference for ecological dynamical systems: a case study of two endemic diseases. ( 0,730326231754712 )
IEEE Trans Pattern Anal Mach Intell - Modeling Natural Images Using Gated MRFs. ( 0,730224418234256 )
Med Decis Making - Bayesian calibration of a natural history model with application to a population model for colorectal cancer. ( 0,726875271075562 )
IEEE Trans Pattern Anal Mach Intell - Negative Binomial Process Count and Mixture Modeling. ( 0,726606727728877 )
IEEE J Biomed Health Inform - Sparsity-inspired nonparametric probability characterization for radio propagation in body area networks. ( 0,726279396606804 )
Med Decis Making - Assessing uncertainties surrounding combined endpoints for use in economic models. ( 0,721082178223017 )
Artif Intell Med - On the interplay of machine learning and background knowledge in image interpretation by Bayesian networks. ( 0,72078597957782 )
Res Synth Methods - Bayesian model selection for meta-analysis of diagnostic test accuracy data: Application to Ddimer for deep vein thrombosis. ( 0,711401666677726 )
Res Synth Methods - Critical interpretation of Cochran's Q test depends on power and prior assumptions about heterogeneity. ( 0,71103589309727 )
Comput Math Methods Med - Bayesian inference of the Weibull model based on interval-censored survival data. ( 0,709422512884786 )
IEEE Trans Image Process - Bayesian inference of models and hyperparameters for robust optical-flow estimation. ( 0,709115040786329 )
Spat Spatiotemporal Epidemiol - A Bayesian space-time model for discrete spread processes on a lattice. ( 0,702970313773291 )
Lifetime Data Anal - Bayesian local influence for survival models. ( 0,699606192159893 )
IEEE Trans Neural Netw Learn Syst - Robust Novelty Detection via Worst Case CVaR Minimization. ( 0,697632516337035 )
IEEE Trans Image Process - Blind separation of time/position varying mixtures. ( 0,69460203672507 )
Med Decis Making - Not simply more of the same: distinguishing between patient heterogeneity and parameter uncertainty. ( 0,694386543374105 )
Comput Math Methods Med - Applications of Bayesian gene selection and classification with mixtures of generalized singular g-priors. ( 0,692277744340995 )
IEEE Trans Image Process - Blind image quality assessment: a natural scene statistics approach in the DCT domain. ( 0,691396030985598 )
IEEE Trans Neural Netw Learn Syst - Variational Bayesian Inference Algorithms for Infinite Relational Model of Network Data. ( 0,685790307152375 )
Med Decis Making - Linear regression metamodeling as a tool to summarize and present simulation model results. ( 0,685226717704996 )
Comput Math Methods Med - Bayesian hierarchical modeling for categorical longitudinal data from sedation measurements. ( 0,682696447057771 )
Brief. Bioinformatics - CaliBayes and BASIS: integrated tools for the calibration, simulation and storage of biological simulation models. ( 0,681921393498581 )
Comput Math Methods Med - An empirical Bayes optimal discovery procedure based on semiparametric hierarchical mixture models. ( 0,680846915367519 )
J Biomed Inform - Link-topic model for biomedical abbreviation disambiguation. ( 0,680165644691289 )
Comput. Biol. Med. - Expectation-maximization technique for fibro-glandular discs detection in mammography images. ( 0,679887921352781 )
IEEE Trans Image Process - A Bayesian framework for image segmentation with spatially varying mixtures. ( 0,677881528351031 )
BMC Med Inform Decis Mak - A simulation model of colorectal cancer surveillance and recurrence. ( 0,67559137343903 )
Comput Methods Programs Biomed - Multivariate Bayesian modeling of known and unknown causes of events--an application to biosurveillance. ( 0,67030440175834 )
IEEE Trans Image Process - Probabilistic image modeling with an extended chain graph for human activity recognition and image segmentation. ( 0,66931527557237 )
J. Comput. Biol. - Bayesian blind source separation for data with network structure. ( 0,665992554313163 )
Comput. Biol. Med. - A pattern-oriented specification of gene network inference processes. ( 0,665688912826534 )
IEEE Trans Image Process - Posterior-mean super-resolution with a causal Gaussian Markov random field prior. ( 0,665249027540233 )
Comput Methods Programs Biomed - Identification of an integrated mathematical model of standard oral glucose tolerance test for characterization of insulin potentiation in health. ( 0,663395179615859 )
IEEE Trans Image Process - Computationally tractable stochastic image modeling based on symmetric Markov mesh random fields. ( 0,662118122674642 )
Spat Spatiotemporal Epidemiol - Foot and mouth disease revisited: re-analysis using Bayesian spatial susceptible-infectious-removed models. ( 0,66065766822029 )
Spat Spatiotemporal Epidemiol - Inference from ecological models: estimating the relative risk of stroke from air pollution exposure using small area data. ( 0,659993907776661 )
AMIA Annu Symp Proc - Testing the calibration of classification models from first principles. ( 0,657583609750816 )
Brief. Bioinformatics - Iteratively reweighted LASSO for mapping multiple quantitative trait loci. ( 0,657524972515833 )
Med Biol Eng Comput - A poisson process model for hip fracture risk. ( 0,654971520893899 )
Spat Spatiotemporal Epidemiol - Mapping gender variation in the spatial pattern of alcohol-related mortality: a Bayesian analysis using data from South Yorkshire, United Kingdom. ( 0,653428225268147 )
Brief. Bioinformatics - Semiparametric prognosis models in genomic studies. ( 0,652943395173082 )
Spat Spatiotemporal Epidemiol - Bayesian hierarchical modeling of the dynamics of spatio-temporal influenza season outbreaks. ( 0,650057042011142 )
Neural Comput - Universal approximation depth and errors of narrow belief networks with discrete units. ( 0,649129246206442 )
J. Comput. Biol. - Exploiting genome structure in association analysis. ( 0,648967404312329 )
J. Comput. Biol. - NP-MuScL: unsupervised global prediction of interaction networks from multiple data sources. ( 0,64849299261389 )
IEEE Trans Image Process - Generative Bayesian image super resolution with natural image prior. ( 0,646169518971564 )
Med Decis Making - Comparing Bayesian and frequentist approaches for multiple outcome mixed treatment comparisons. ( 0,645849865971498 )
Spat Spatiotemporal Epidemiol - A space-time point process model for analyzing and predicting case patterns of diarrheal disease in northwestern Ecuador. ( 0,642775223544889 )
Neural Comput - Attention as reward-driven optimization of sensory processing. ( 0,641328357074682 )
IEEE Trans Pattern Anal Mach Intell - Temporal Analysis of Motif Mixtures using Dirichlet Processes. ( 0,641320162355688 )
Res Synth Methods - A basic introduction to fixed-effect and random-effects models for meta-analysis. ( 0,641309205085919 )
Med Decis Making - Accounting for methodological, structural, and parameter uncertainty in decision-analytic models: a practical guide. ( 0,639433593335279 )
Spat Spatiotemporal Epidemiol - A Bayesian hierarchical model of nontraumatic lower-extremity amputation rates. ( 0,636315952640902 )
Comput Methods Programs Biomed - On the prediction of glucose concentration under intra-patient variability in type 1 diabetes: a monotone systems approach. ( 0,63262256876758 )
Neural Comput - Efficient Markov chain Monte Carlo methods for decoding neural spike trains. ( 0,631040852183028 )
IEEE Trans Pattern Anal Mach Intell - Causal Inference on Discrete Data using Additive Noise Models. ( 0,62836286381212 )
J. Comput. Biol. - On the inference of dirichlet mixture priors for protein sequence comparison. ( 0,628248988636209 )
Comput Methods Programs Biomed - Life prediction of different commercial dental implants as influence by uncertainties in their fatigue material properties and loading conditions. ( 0,627118259122129 )
IEEE Trans Image Process - Bayesian estimation of linear mixtures using the normal compositional model. Application to hyperspectral imagery. ( 0,626464121569368 )
Spat Spatiotemporal Epidemiol - The detection of spatially localised outbreaks in campylobacteriosis notification data. ( 0,624553697841662 )
J. Comput. Biol. - An efficient data assimilation schema for restoration and extension of gene regulatory networks using time-course observation data. ( 0,62451895042159 )
Artif Intell Med - Scalable approximate policies for Markov decision process models of hospital elective admissions. ( 0,622126849800874 )
IEEE Trans Neural Netw Learn Syst - Incorporating Wind Power Forecast Uncertainties Into Stochastic Unit Commitment Using Neural Network-Based Prediction Intervals. ( 0,621388509904494 )
Neural Comput - The basal ganglia optimize decision making over general perceptual hypotheses. ( 0,620073074333964 )
IEEE Trans Image Process - A Kullback-Leibler divergence approach to blind image restoration. ( 0,616233827516185 )
Int J Health Geogr - Gumbel based p-value approximations for spatial scan statistics. ( 0,615060873664989 )
Comput. Biol. Med. - BootstRatio: A web-based statistical analysis of fold-change in qPCR and RT-qPCR data using resampling methods. ( 0,61136186126417 )
Neural Comput - Multiple tests based on a gaussian approximation of the unitary events method with delayed coincidence count. ( 0,608490172284478 )
IEEE Trans Image Process - Counting people with low-level features and Bayesian regression. ( 0,607209845776871 )
IEEE Trans Image Process - A Bayesian hierarchical factorization model for vector fields. ( 0,606717967485339 )
Artif Intell Med - Impact of precision of Bayesian network parameters on accuracy of medical diagnostic systems. ( 0,606633035354096 )
Neural Comput - The neural representation of time: an information-theoretic perspective. ( 0,605846971811344 )
Comput Methods Programs Biomed - A Bayesian multilevel model for fMRI data analysis. ( 0,605581351229665 )
Med Decis Making - Exploring model uncertainty in economic evaluation of health interventions: the example of rotavirus vaccination in Vietnam. ( 0,605427627039467 )
Res Synth Methods - Random-effects meta-analysis of time-to-event data using the expectation-maximisation algorithm and shrinkage estimators. ( 0,604223911877375 )
Neural Comput - Bayesian sparse partial least squares. ( 0,604100478557336 )
Neural Comput - Simple deterministically constructed cycle reservoirs with regular jumps. ( 0,602690909119872 )
Res Synth Methods - Automating network meta-analysis. ( 0,602161833695435 )
BMC Med Inform Decis Mak - A novel differential diagnostic model based on multiple biological parameters for immunoglobulin A nephropathy. ( 0,601360381880925 )
J Biomed Inform - Learning patient-specific predictive models from clinical data. ( 0,601050524431588 )
J Integr Bioinform - Analyzing phylogenetic trees with timed and probabilistic model checking: the lactose persistence case study. ( 0,599320882634663 )
Comput Math Methods Med - Locomotor development prediction based on statistical model parameters identification. ( 0,598290536639435 )
J. Comput. Biol. - Identifying contributors of DNA mixtures by means of quantitative information of STR typing. ( 0,595489121443921 )
IEEE Trans Vis Comput Graph - The Perception of Visual Uncertainty Representation by Non-Experts. ( 0,592122614593342 )
IEEE Trans Pattern Anal Mach Intell - Articulated Human Detection with Flexible Mixtures-of-Parts. ( 0,590920122895631 )
Lifetime Data Anal - Diagnostic tools for bivariate accelerated life regression models. ( 0,590840151298303 )