J. Comput. Biol. - On the A-optimality criterion for finding two-color microarray optimal designs.

Tópicos

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Resumo

Several studies on two-color microarray experimental designs consider the A-optimality criterion for the assessment and/or search of appropriate/optimal designs. What seems to be widely ignored, however, is the well-known fact that A-optimal designs depend on the choice of scale or code combination of the X-variables. In this article, it is shown that intrinsically different optimal microarray designs will be obtained depending on the chosen code combination of the qualitative factors. Moreover, a substantial loss in efficiency will result when a design, which is optimal for a specific code combination, is used for another one. This coding problematic is also applicable to the admissibility concept.

Resumo Limpo

sever studi twocolor microarray experiment design consid aoptim criterion assess andor search appropriateoptim design seem wide ignor howev wellknown fact aoptim design depend choic scale code combin xvariabl articl shown intrins differ optim microarray design will obtain depend chosen code combin qualit factor moreov substanti loss effici will result design optim specif code combin use anoth one code problemat also applic admiss concept

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