J. Med. Internet Res. - Consumers' use of web-based information and their decisions about multiplex genetic susceptibility testing.

Tópicos

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Resumo

CKGROUND: Few data exist to inform concerns raised by online direct-to-consumer marketing of genetic susceptibility tests, such as those offered by commercial entities like 23andme, Navigenics, and DNA Direct. The Multiplex Initiative, a population-based study of healthy adults, provides the first opportunity to evaluate how use of a Web-based decision tool that conveyed information about a genetic susceptibility test influenced individuals' test decisions.OBJECTIVE: To inform the ongoing debate over whether individuals offered genetic susceptibility testing without the involvement of a health care provider (eg, through direct-to-consumer testing) can make informed decisions about testing when guided by online decision aids.METHODS: Participants were 526 members of a large health maintenance organization aged 25 to 40 years old who visited a study website. Multivariate logistic regression models were tested to examine the association of website usage with downstream test decisions.RESULTS: Participants viewed an average of 2.9 of the 4 pages introducing the multiplex test, 2.2 of the 8 pages describing the health conditions, and 3.2 of the 15 pages describing the genes. For each page viewed, participants were more likely to describe their decision-making as easy (odds ratio [OR] 1.04, 95% confidence interval [CI] 1.01-1.07) and to decide to be tested (OR 1.08, 95% CI 1.05-1.11).CONCLUSIONS: Healthy adults in this study perceived Web-based genomic information presented using evidence-based communications approaches to be helpful in supporting both decisions to test and not to test. Continued research is needed to ensure that these results generalize to target groups with lower literacy and less Internet savvy.

Resumo Limpo

ckground data exist inform concern rais onlin directtoconsum market genet suscept test offer commerci entiti like andm navigen dna direct multiplex initi populationbas studi healthi adult provid first opportun evalu use webbas decis tool convey inform genet suscept test influenc individu test decisionsobject inform ongo debat whether individu offer genet suscept test without involv health care provid eg directtoconsum test can make inform decis test guid onlin decis aidsmethod particip member larg health mainten organ age year old visit studi websit multivari logist regress model test examin associ websit usag downstream test decisionsresult particip view averag page introduc multiplex test page describ health condit page describ gene page view particip like describ decisionmak easi odd ratio confid interv ci decid test ci conclus healthi adult studi perceiv webbas genom inform present use evidencebas communic approach help support decis test test continu research need ensur result general target group lower literaci less internet savvi

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