BMC Med Inform Decis Mak - Evaluation of a drug-drug interaction: fax alert intervention program.

Tópicos

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Resumo

CKGROUND: Clinicians often encounter information about drug-drug interactions (DDIs) during clinical practice. This information is found within product information (hardcopy and electronic) and various electronic systems. Prescribers may receive medication-related communications in practice that are distributed by facsimile (fax), mail, or telephone from pharmacies and pharmacy benefit managers (PBMs). The purpose of this study was to determine if near-real time fax alerts for potential drug-drug interactions (PDDIs) would influence prescribing.METHODS: A prospective study, in cooperation with a pharmacy benefit manager (PBM), was conducted targeting 18 clinically important PDDIs. Fax alerts included an individualized letter to the prescriber with a list of the interacting drugs, PDDI evidence summaries with citations, and recommended clinical management strategies. Among the 18 PDDIs, 13 PDDIs could be assessed for prescription therapy changes using pharmacy claims data. A prospective cohort design was used to evaluate changes in prescription dispensing 90-days following a PDDI fax alert.RESULTS: A total of 8,075 fax alerts were sent to prescribers and there were 4,712 alerts for the 13 PDDIs that could be assessed for change using pharmacy claims data. There were 2,019 patients (interventions) for which fax alerts were sent to their prescribers who were matched with a control group consisting of patients with the same PDDIs but for whom no fax alert was sent. Overall, this study found 154 (7.6%) of patients in the fax alert group compared to 132 (6.5%) in the control group had changes in therapy (p = 0.177).CONCLUSIONS: This fax alert intervention program observed no statistically significant differences in prescribing with a fax alert compared to the control group. If PBMs chose to send individualized, evidence-based information to clinicians regarding drug-drug interactions, this study suggests it may not be an effective intervention to mitigate harm.

Resumo Limpo

ckground clinician often encount inform drugdrug interact ddis clinic practic inform found within product inform hardcopi electron various electron system prescrib may receiv medicationrel communic practic distribut facsimil fax mail telephon pharmaci pharmaci benefit manag pbms purpos studi determin nearreal time fax alert potenti drugdrug interact pddis influenc prescribingmethod prospect studi cooper pharmaci benefit manag pbm conduct target clinic import pddis fax alert includ individu letter prescrib list interact drug pddi evid summari citat recommend clinic manag strategi among pddis pddis assess prescript therapi chang use pharmaci claim data prospect cohort design use evalu chang prescript dispens day follow pddi fax alertresult total fax alert sent prescrib alert pddis assess chang use pharmaci claim data patient intervent fax alert sent prescrib match control group consist patient pddis fax alert sent overal studi found patient fax alert group compar control group chang therapi p conclus fax alert intervent program observ statist signific differ prescrib fax alert compar control group pbms chose send individu evidencebas inform clinician regard drugdrug interact studi suggest may effect intervent mitig harm

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