J. Med. Internet Res. - Effects of a guided web-based smoking cessation program with telephone counseling: a cluster randomized controlled trial.

Tópicos

{ intervent(3218) particip(2042) group(1664) }
{ studi(1410) differ(1259) use(1210) }
{ patient(2837) hospit(1953) medic(668) }
{ time(1939) patient(1703) rate(768) }
{ control(1307) perform(991) simul(935) }
{ sequenc(1873) structur(1644) protein(1328) }
{ activ(1452) weight(1219) physic(1104) }
{ detect(2391) sensit(1101) algorithm(908) }
{ take(945) account(800) differ(722) }
{ age(1611) year(1155) adult(843) }
{ motion(1329) object(1292) video(1091) }
{ perform(999) metric(946) measur(919) }
{ ehr(2073) health(1662) electron(1139) }
{ health(3367) inform(1360) care(1135) }
{ signal(2180) analysi(812) frequenc(800) }
{ data(3008) multipl(1320) sourc(1022) }
{ method(1219) similar(1157) match(930) }
{ patient(2315) diseas(1263) diabet(1191) }
{ chang(1828) time(1643) increas(1301) }
{ general(901) number(790) one(736) }
{ case(1353) use(1143) diagnosi(1136) }
{ monitor(1329) mobil(1314) devic(1160) }
{ data(2317) use(1299) case(1017) }
{ sampl(1606) size(1419) use(1276) }
{ high(1669) rate(1365) level(1280) }
{ use(976) code(926) identifi(902) }
{ use(1733) differ(960) four(931) }
{ implement(1333) system(1263) develop(1122) }
{ survey(1388) particip(1329) question(1065) }
{ decis(3086) make(1611) patient(1517) }
{ process(1125) use(805) approach(778) }
{ model(3404) distribut(989) bayesian(671) }
{ can(774) often(719) complex(702) }
{ imag(1947) propos(1133) code(1026) }
{ data(1737) use(1416) pattern(1282) }
{ inform(2794) health(2639) internet(1427) }
{ system(1976) rule(880) can(841) }
{ measur(2081) correl(1212) valu(896) }
{ imag(1057) registr(996) error(939) }
{ bind(1733) structur(1185) ligand(1036) }
{ featur(3375) classif(2383) classifi(1994) }
{ imag(2830) propos(1344) filter(1198) }
{ network(2748) neural(1063) input(814) }
{ imag(2675) segment(2577) method(1081) }
{ studi(2440) review(1878) systemat(933) }
{ assess(1506) score(1403) qualiti(1306) }
{ treatment(1704) effect(941) patient(846) }
{ surgeri(1148) surgic(1085) robot(1054) }
{ framework(1458) process(801) describ(734) }
{ problem(2511) optim(1539) algorithm(950) }
{ error(1145) method(1030) estim(1020) }
{ learn(2355) train(1041) set(1003) }
{ concept(1167) ontolog(924) domain(897) }
{ clinic(1479) use(1117) guidelin(835) }
{ algorithm(1844) comput(1787) effici(935) }
{ extract(1171) text(1153) clinic(932) }
{ method(1557) propos(1049) approach(1037) }
{ data(1714) softwar(1251) tool(1186) }
{ design(1359) user(1324) use(1319) }
{ model(2220) cell(1177) simul(1124) }
{ care(1570) inform(1187) nurs(1089) }
{ method(984) reconstruct(947) comput(926) }
{ search(2224) databas(1162) retriev(909) }
{ featur(1941) imag(1645) propos(1176) }
{ howev(809) still(633) remain(590) }
{ data(3963) clinic(1234) research(1004) }
{ risk(3053) factor(974) diseas(938) }
{ research(1085) discuss(1038) issu(1018) }
{ system(1050) medic(1026) inform(1018) }
{ import(1318) role(1303) understand(862) }
{ model(2341) predict(2261) use(1141) }
{ visual(1396) interact(850) tool(830) }
{ compound(1573) activ(1297) structur(1058) }
{ perform(1367) use(1326) method(1137) }
{ studi(1119) effect(1106) posit(819) }
{ blood(1257) pressur(1144) flow(957) }
{ spatial(1525) area(1432) region(1030) }
{ record(1888) medic(1808) patient(1693) }
{ model(3480) simul(1196) paramet(876) }
{ state(1844) use(1261) util(961) }
{ research(1218) medic(880) student(794) }
{ model(2656) set(1616) predict(1553) }
{ medic(1828) order(1363) alert(1069) }
{ cost(1906) reduc(1198) effect(832) }
{ group(2977) signific(1463) compar(1072) }
{ gene(2352) biolog(1181) express(1162) }
{ first(2504) two(1366) second(1323) }
{ activ(1138) subject(705) human(624) }
{ patient(1821) servic(1111) care(1106) }
{ use(2086) technolog(871) perceiv(783) }
{ can(981) present(881) function(850) }
{ analysi(2126) use(1163) compon(1037) }
{ health(1844) social(1437) communiti(874) }
{ structur(1116) can(940) graph(676) }
{ cancer(2502) breast(956) screen(824) }
{ drug(1928) target(777) effect(648) }
{ result(1111) use(1088) new(759) }
{ estim(2440) model(1874) function(577) }
{ method(1969) cluster(1462) data(1082) }
{ method(2212) result(1239) propos(1039) }

Resumo

CKGROUND: Preliminary findings suggest that Web-based interventions may be effective in achieving significant smoking cessation. To date, very few findings are available for primary care patients, and especially for the involvement of general practitioners.OBJECTIVE: Our goal was to examine the short-term effectiveness of a fully automated Web-based coaching program in combination with accompanied telephone counseling in smoking cessation in a primary care setting.METHODS: The study was an unblinded cluster-randomized trial with an observation period of 12 weeks. Individuals recruited by general practitioners randomized to the intervention group participated in a Web-based coaching program based on education, motivation, exercise guidance, daily short message service (SMS) reminding, weekly feedback through Internet, and active monitoring by general practitioners. All components of the program are fully automated. Participants in the control group received usual care and advice from their practitioner without the Web-based coaching program. The main outcome was the biochemically confirmed smoking status after 12 weeks.RESULTS: We recruited 168 participants (86 intervention group, 82 control group) into the study. For 51 participants from the intervention group and 70 participants from the control group, follow-up data were available both at baseline and 12 weeks. Very few patients (9.8%, 5/51) from the intervention group and from the control group (8.6%, 6/70) successfully managed smoking cessation (OR 0.86, 95% CI 0.25-3.0; P=.816). Similar results were found within the intent-to-treat analysis: 5.8% (5/86) of the intervention group and 7.3% (6/82) of the control group (OR 1.28, 95% CI 0.38-4.36; P=.694). The number of smoked cigarettes per day decreased on average by 9.3 in the intervention group and by 6.6 in the control group (2.7 mean difference; 95% CI -5.33 to -0.58; P=.045). After adjustment for the baseline value, age, gender, and height, this significance decreases (mean difference 2.2; 95% CI -4.7 to 0.3; P=.080).CONCLUSIONS: This trial did not show that the tested Web-based intervention was effective for achieving smoking cessation compared to usual care. The limited statistical power and the high drop-out rate may have reduced the study's ability to detect significant differences between the groups. Further randomized controlled trials are needed in larger populations and to investigate the long-term outcome.TRIAL REGISTRATION: German Register for Clinical Trials, registration number DRKS00003067; http://drks-neu.uniklinik-freiburg.de/drks_web/navigate.do?navigationId=trial.HTML&TRIAL_ ID=DRKS00003067 (Archived by WebCite at http://www.webcitation.org/6Sff1YZpx).

Resumo Limpo

ckground preliminari find suggest webbas intervent may effect achiev signific smoke cessat date find avail primari care patient especi involv general practitionersobject goal examin shortterm effect fulli autom webbas coach program combin accompani telephon counsel smoke cessat primari care settingmethod studi unblind clusterrandom trial observ period week individu recruit general practition random intervent group particip webbas coach program base educ motiv exercis guidanc daili short messag servic sms remind week feedback internet activ monitor general practition compon program fulli autom particip control group receiv usual care advic practition without webbas coach program main outcom biochem confirm smoke status weeksresult recruit particip intervent group control group studi particip intervent group particip control group followup data avail baselin week patient intervent group control group success manag smoke cessat ci p similar result found within intenttotreat analysi intervent group control group ci p number smoke cigarett per day decreas averag intervent group control group mean differ ci p adjust baselin valu age gender height signific decreas mean differ ci pconclus trial show test webbas intervent effect achiev smoke cessat compar usual care limit statist power high dropout rate may reduc studi abil detect signific differ group random control trial need larger popul investig longterm outcometri registr german regist clinic trial registr number drks httpdrksneuuniklinikfreiburgdedrkswebnavigatedonavigationidtrialhtmltri iddrk archiv webcit httpwwwwebcitationorgsffyzpx

Resumos Similares

J Telemed Telecare - A pilot programme using mobile phones for HIV prevention. ( 0,961673059744164 )
J. Med. Internet Res. - A web-based program improves physical activity outcomes in a primary care angina population: randomized controlled trial. ( 0,958013840052001 )
J. Med. Internet Res. - Effect of tailoring in an internet-based intervention for smoking cessation: randomized controlled trial. ( 0,95553587511539 )
J. Med. Internet Res. - Efficacy of a text message-based smoking cessation intervention for young people: a cluster randomized controlled trial. ( 0,949711307520183 )
Int J Med Inform - Results of a randomized controlled trial to assess the effects of a mobile SMS-based intervention on treatment adherence in HIV/AIDS-infected Brazilian women and impressions and satisfaction with respect to incoming messages. ( 0,942258223872994 )
J. Med. Internet Res. - A text messaging-based smoking cessation program for adult smokers: randomized controlled trial. ( 0,941042042757385 )
J. Med. Internet Res. - Two fully automated web-based interventions for risky alcohol use: randomized controlled trial. ( 0,940611219636937 )
J. Med. Internet Res. - Preventing smoking relapse via Web-based computer-tailored feedback: a randomized controlled trial. ( 0,939941934587152 )
J. Med. Internet Res. - Efficacy of a Web-based computer-tailored smoking prevention intervention for Dutch adolescents: randomized controlled trial. ( 0,938747938166906 )
J. Med. Internet Res. - Prevention of generalized anxiety disorder using a web intervention, iChill: randomized controlled trial. ( 0,938494087358768 )
J. Med. Internet Res. - Effectiveness of a web-based brief alcohol intervention and added value of normative feedback in reducing underage drinking: a randomized controlled trial. ( 0,93611161556065 )
J. Med. Internet Res. - Using ecological momentary assessment to test the effectiveness of a web-based brief alcohol intervention over time among heavy-drinking students: randomized controlled trial. ( 0,933018223465311 )
J. Med. Internet Res. - Internet-based recruitment to a depression prevention intervention: lessons from the Mood Memos study. ( 0,931982861200072 )
J. Med. Internet Res. - Development and preliminary evaluation of an internet-based healthy eating program: randomized controlled trial. ( 0,927728348492315 )
J. Med. Internet Res. - Improving adherence to antiretroviral therapy for youth living with HIV/AIDS: a pilot study using personalized, interactive, daily text message reminders. ( 0,927659729430951 )
J. Med. Internet Res. - Effectiveness of different Web-based interventions to prepare co-smokers of cigarettes and cannabis for double cessation: a three-arm randomized controlled trial. ( 0,92635002946524 )
J. Med. Internet Res. - Effectiveness of a Web-based multiple tailored smoking cessation program: a randomized controlled trial among Dutch adult smokers. ( 0,924311618386213 )
J. Med. Internet Res. - A smartphone-based intervention with diaries and therapist-feedback to reduce catastrophizing and increase functioning in women with chronic widespread pain: randomized controlled trial. ( 0,923492564017723 )
BMC Med Inform Decis Mak - Effects of and satisfaction with short message service reminders for patient medication adherence: a randomized controlled study. ( 0,922715568501867 )
J. Med. Internet Res. - Periodic email prompts to re-use an internet-delivered computer-tailored lifestyle program: influence of prompt content and timing. ( 0,921181658903374 )
J. Med. Internet Res. - Adherence to a smartphone application for weight loss compared to website and paper diary: pilot randomized controlled trial. ( 0,920212988665403 )
J. Med. Internet Res. - Interpreting the outcomes of automated internet-based randomized trials: example of an International Smoking Cessation Study. ( 0,919123395761441 )
J. Med. Internet Res. - Impact of seasonality on recruitment, retention, adherence, and outcomes in a web-based smoking cessation intervention: randomized controlled trial. ( 0,918260048029858 )
J. Med. Internet Res. - Internet-based brief personalized feedback intervention in a non-treatment-seeking population of adult heavy drinkers: a randomized controlled trial. ( 0,915156067060878 )
J. Med. Internet Res. - Daily text messaging for weight control among racial and ethnic minority women: randomized controlled pilot study. ( 0,914706306477478 )
J. Med. Internet Res. - Enhancing retention of an Internet-based cohort study of men who have sex with men (MSM) via text messaging: randomized controlled trial. ( 0,914007927435459 )
Int J Med Inform - Engagement in My Child's Asthma, an interactive web-based pediatric asthma management intervention. ( 0,911956357182339 )
J. Med. Internet Res. - A theory-based video messaging mobile phone intervention for smoking cessation: randomized controlled trial. ( 0,911764666640243 )
J. Med. Internet Res. - Evaluation of a Web-based intervention to promote hand hygiene: exploratory randomized controlled trial. ( 0,911450597213152 )
Int J Med Inform - Evaluation of mobile phone and Internet intervention on waist circumference and blood pressure in post-menopausal women with abdominal obesity. ( 0,9114365178948 )
J. Med. Internet Res. - Web-enhanced tobacco tactics with telephone support versus 1-800-QUIT-NOW telephone line intervention for operating engineers: randomized controlled trial. ( 0,910100962817245 )
J. Med. Internet Res. - Use of email and telephone prompts to increase self-monitoring in a Web-based intervention: randomized controlled trial. ( 0,909130452744863 )
J. Med. Internet Res. - Does brief telephone support improve engagement with a web-based weight management intervention? Randomized controlled trial. ( 0,906137743392034 )
J. Med. Internet Res. - Web-based cognitive behavioral self-help intervention to reduce cocaine consumption in problematic cocaine users: randomized controlled trial. ( 0,905369179610925 )
J. Med. Internet Res. - Internal versus external motivation in referral of primary care patients with depression to an internet support group: randomized controlled trial. ( 0,904857578673045 )
J. Med. Internet Res. - MEMO--a mobile phone depression prevention intervention for adolescents: development process and postprogram findings on acceptability from a randomized controlled trial. ( 0,900977904466786 )
J. Med. Internet Res. - Effectiveness of Web-based versus face-to-face delivery of education in prescription of falls-prevention exercise to health professionals: randomized trial. ( 0,89988017009077 )
BMC Med Inform Decis Mak - Process evaluation of a web-based intervention aimed at empowerment of disability benefit claimants. ( 0,898191877134557 )
J. Med. Internet Res. - Engagement and retention: measuring breadth and depth of participant use of an online intervention. ( 0,897153897736509 )
J. Med. Internet Res. - Effectiveness of a Web-based intervention aimed at healthy dietary and physical activity behavior: a randomized controlled trial about users and usage. ( 0,896508285410953 )
J. Med. Internet Res. - Effects of a Web-based tailored intervention to reduce alcohol consumption in adults: randomized controlled trial. ( 0,895917095381197 )
J. Med. Internet Res. - Influence of delivery strategy on message-processing mechanisms and future adherence to a Dutch computer-tailored smoking cessation intervention. ( 0,895405843958964 )
J. Med. Internet Res. - Short-term effectiveness of web-based guided self-help for phobic outpatients: randomized controlled trial. ( 0,895068363840391 )
J Telemed Telecare - Use of mobile phone text messaging to deliver an individualized smoking behaviour intervention in Chinese adolescents. ( 0,894357697390766 )
J. Med. Internet Res. - Effectiveness of a proactive mail-based alcohol Internet intervention for university students: dismantling the assessment and feedback components in a randomized controlled trial. ( 0,893541523833197 )
J. Med. Internet Res. - Participants, usage, and use patterns of a web-based intervention for the prevention of depression within a randomized controlled trial. ( 0,890420064684005 )
J. Med. Internet Res. - Do email and mobile phone prompts stimulate primary school children to reuse an Internet-delivered smoking prevention intervention? ( 0,890039076342308 )
J. Med. Internet Res. - Development of web-based computer-tailored advice to promote physical activity among people older than 50 years. ( 0,889422172340807 )
J. Med. Internet Res. - Cardiovascular health effects of internet-based encouragements to do daily workplace stair-walks: randomized controlled trial. ( 0,887583202986652 )
Telemed J E Health - Effectiveness of healthy relationships video-group-A videoconferencing group intervention for women living with HIV: preliminary findings from a randomized controlled trial. ( 0,886983012370962 )
J. Med. Internet Res. - Exploratory study of web-based planning and mobile text reminders in an overweight population. ( 0,885873013220895 )
J. Med. Internet Res. - The effects of combining Web-based eHealth with telephone nurse case management for pediatric asthma control: a randomized controlled trial. ( 0,884571307712342 )
J. Med. Internet Res. - The effectiveness of a Web-based personalized feedback and social norms alcohol intervention on United Kingdom university students: randomized controlled trial. ( 0,883236463907603 )
J Telemed Telecare - Efficacy of a programme for workers with metabolic syndrome based on an e-health system in the workplace: a pilot study. ( 0,883196685464224 )
J. Med. Internet Res. - Usage of a generic web-based self-management intervention for breast cancer survivors: substudy analysis of the BREATH trial. ( 0,882543745297058 )
J. Med. Internet Res. - Overcoming Addictions, a Web-based application, and SMART Recovery, an online and in-person mutual help group for problem drinkers, part 1: three-month outcomes of a randomized controlled trial. ( 0,880134911971969 )
J. Med. Internet Res. - Engagement in a diabetes self-management website: usage patterns and generalizability of program use. ( 0,879950805641529 )
J. Med. Internet Res. - Do participants' preferences for mode of delivery (text, video, or both) influence the effectiveness of a Web-based physical activity intervention? ( 0,87823454591166 )
J. Med. Internet Res. - Effectiveness of web-based self-disclosure peer-to-peer support for weight loss: randomized controlled trial. ( 0,877958029886783 )
J. Med. Internet Res. - Initial and sustained participation in an internet-delivered long-term worksite health promotion program on physical activity and nutrition. ( 0,877694539538706 )
J. Med. Internet Res. - A service-based evaluation of a therapist-supported online cognitive behavioral therapy program for depression. ( 0,876943752687448 )
J Telemed Telecare - A review of the use of mobile phone text messaging in clinical and healthy behaviour interventions. ( 0,876445322052007 )
J. Med. Internet Res. - A web-based sexual violence bystander intervention for male college students: randomized controlled trial. ( 0,873421518539194 )
J. Med. Internet Res. - Surviving and thriving with cancer using a Web-based health behavior change intervention: randomized controlled trial. ( 0,873279513334034 )
J. Med. Internet Res. - Differences in reach and attrition between Web-based and print-delivered tailored interventions among adults over 50 years of age: clustered randomized trial. ( 0,871415077167025 )
J. Med. Internet Res. - Feasibility and effectiveness of a web-based positive psychology program for youth mental health: randomized controlled trial. ( 0,868454399223292 )
J. Med. Internet Res. - Demographic, behavioral, and psychosocial correlates of using the website component of a worksite physical activity and healthy nutrition promotion program: a longitudinal study. ( 0,867613997060035 )
J. Med. Internet Res. - The effect of program design on engagement with an internet-based smoking intervention: randomized factorial trial. ( 0,867332788424302 )
J. Med. Internet Res. - Comparison of text and video computer-tailored interventions for smoking cessation: randomized controlled trial. ( 0,86701036565833 )
J Telemed Telecare - The effect of psychosocial interventions delivered by telephone and videophone on quality of life in early-stage breast cancer survivors and their supportive partners. ( 0,858213486337011 )
J. Med. Internet Res. - A smartphone-based intervention with diaries and therapist feedback to reduce catastrophizing and increase functioning in women with chronic widespread pain. part 2: 11-month follow-up results of a randomized trial. ( 0,857873899690763 )
J Am Med Inform Assoc - The Diabetes Telemonitoring Study Extension: an exploratory randomized comparison of alternative interventions to maintain glycemic control after withdrawal of diabetes home telemonitoring. ( 0,856164728875396 )
J. Med. Internet Res. - Engagement promotes abstinence in a web-based cessation intervention: cohort study. ( 0,85610799422929 )
J. Med. Internet Res. - Impact of length or relevance of questionnaires on attrition in online trials: randomized controlled trial. ( 0,85552508954523 )
J. Med. Internet Res. - An Internet- and mobile-based tailored intervention to enhance maintenance of physical activity after cardiac rehabilitation: short-term results of a randomized controlled trial. ( 0,855268740032342 )
J. Med. Internet Res. - Effectiveness of a web-based physical activity intervention in patients with knee and/or hip osteoarthritis: randomized controlled trial. ( 0,854552501477592 )
J. Med. Internet Res. - Adherence to self-monitoring via interactive voice response technology in an eHealth intervention targeting weight gain prevention among Black women: randomized controlled trial. ( 0,854436767483707 )
Telemed J E Health - Effectiveness of home telehealth in comorbid diabetes and hypertension: a randomized, controlled trial. ( 0,8542914475356 )
J. Med. Internet Res. - Use of a text message program to raise type 2 diabetes risk awareness and promote health behavior change (part I): assessment of participant reach and adoption. ( 0,853751000220554 )
J. Med. Internet Res. - Partnership for health-2, a web-based versus print smoking cessation intervention for childhood and young adult cancer survivors: randomized comparative effectiveness study. ( 0,851799537356042 )
Telemed J E Health - Can an evidence-based book club intervention delivered via a tablet computer improve physical activity in middle-aged women? ( 0,851438444600015 )
J. Med. Internet Res. - Effect of a Web-based intervention to promote physical activity and improve health among physically inactive adults: a population-based randomized controlled trial. ( 0,851437306923683 )
J. Med. Internet Res. - A comparison between phone-based psychotherapy with and without text messaging support in between sessions for crisis patients. ( 0,850238145504712 )
J. Med. Internet Res. - Effectiveness of a Web-based tailored intervention (E-health4Uth) and consultation to promote adolescents' health: randomized controlled trial. ( 0,849652467847031 )
J. Med. Internet Res. - Comparison of trial participants and open access users of a web-based physical activity intervention regarding adherence, attrition, and repeated participation. ( 0,849417653620297 )
J. Med. Internet Res. - Effects of internet-based tailored advice on the use of cholesterol-lowering interventions: a randomized controlled trial. ( 0,849021817299641 )
J. Med. Internet Res. - Reducing alcohol use during pregnancy via health counseling by midwives and internet-based computer-tailored feedback: a cluster randomized trial. ( 0,845704896855713 )
Telemed J E Health - Randomized trial of a smartphone mobile application compared to text messaging to support smoking cessation. ( 0,844875984505413 )
J. Med. Internet Res. - Providing web-based feedback and social norms information to reduce student alcohol intake: a multisite investigation. ( 0,842013683826214 )
J. Med. Internet Res. - Pedometer-based internet-mediated intervention for adults with chronic low back pain: randomized controlled trial. ( 0,841014466623061 )
J. Med. Internet Res. - Using the internet to promote health behavior change: a systematic review and meta-analysis of the impact of theoretical basis, use of behavior change techniques, and mode of delivery on efficacy. ( 0,840855919384581 )
J. Med. Internet Res. - The effectiveness of loyalty rewards to promote the use of an Internet-based heart health program. ( 0,840167442620068 )
J. Med. Internet Res. - Curbing alcohol use in male adults through computer generated personalized advice: randomized controlled trial. ( 0,84008616449446 )
J. Med. Internet Res. - Economic evaluation of a web-based tailored lifestyle intervention for adults: findings regarding cost-effectiveness and cost-utility from a randomized controlled trial. ( 0,837025943278384 )
J. Med. Internet Res. - Motivational interviewing in a Web-based physical activity intervention with an avatar: randomized controlled trial. ( 0,834382648993891 )
J Telemed Telecare - Effect of mobile phone-based psychotherapy in suicide prevention: a randomized controlled trial in Sri Lanka. ( 0,831447814022975 )
BMC Med Inform Decis Mak - A cohort study of a tailored web intervention for preconception care. ( 0,831241369421524 )
J. Med. Internet Res. - Effectiveness of a web-based intervention for problem drinkers and reasons for dropout: randomized controlled trial. ( 0,830532899726053 )
J. Med. Internet Res. - Effectiveness of web-based tailored advice on parents' child safety behaviors: randomized controlled trial. ( 0,83017845532142 )
J. Med. Internet Res. - Multilevel growth curve analyses of treatment effects of a Web-based intervention for stress reduction: randomized controlled trial. ( 0,829103942703435 )