Lifetime Data Anal - Semiparametric inference on the absolute risk reduction and the restricted mean survival difference.

Tópicos

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Resumo

For time-to-event data, when the hazards are non-proportional, in addition to the hazard ratio, the absolute risk reduction and the restricted mean survival difference can be used to describe the time-dependent treatment effect. The absolute risk reduction measures the direct impact of the treatment on event rate or survival, and the restricted mean survival difference provides a way to evaluate the cumulative treatment effect. However, in the literature, available methods are limited for flexibly estimating these measures and making inference on them. In this article, point estimates, pointwise confidence intervals and simultaneous confidence bands of the absolute risk reduction and the restricted mean survival difference are established under a semiparametric model that can be used in a sufficiently wide range of applications. These methods are motivated by and illustrated for data from the Women's Health Initiative estrogen plus progestin clinical trial.

Resumo Limpo

timetoev data hazard nonproport addit hazard ratio absolut risk reduct restrict mean surviv differ can use describ timedepend treatment effect absolut risk reduct measur direct impact treatment event rate surviv restrict mean surviv differ provid way evalu cumul treatment effect howev literatur avail method limit flexibl estim measur make infer articl point estim pointwis confid interv simultan confid band absolut risk reduct restrict mean surviv differ establish semiparametr model can use suffici wide rang applic method motiv illustr data women health initi estrogen plus progestin clinic trial

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