Lifetime Data Anal - Regression analysis for cumulative incidence probability under competing risks and left-truncated sampling.

Tópicos

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Resumo

The cumulative incidence function provides intuitive summary information about competing risks data. Via a mixture decomposition of this function, Chang and Wang (Statist. Sinca 19:391-408, 2009) study how covariates affect the cumulative incidence probability of a particular failure type at a chosen time point. Without specifying the corresponding failure time distribution, they proposed two estimators and derived their large sample properties. The first estimator utilized the technique of weighting to adjust for the censoring bias, and can be considered as an extension of Fine's method (J R Stat Soc Ser B 61: 817-830, 1999). The second used imputation and extends the idea of Wang (J R Stat Soc Ser B 65: 921-935, 2003) from a nonparametric setting to the current regression framework. In this article, when covariates take only discrete values, we extend both approaches of Chang and Wang (Statist Sinca 19:391-408, 2009) by allowing left truncation. Large sample properties of the proposed estimators are derived, and their finite sample performance is investigated through a simulation study. We also apply our methods to heart transplant survival data.

Resumo Limpo

cumul incid function provid intuit summari inform compet risk data via mixtur decomposit function chang wang statist sinca studi covari affect cumul incid probabl particular failur type chosen time point without specifi correspond failur time distribut propos two estim deriv larg sampl properti first estim util techniqu weight adjust censor bias can consid extens fine method j r stat soc ser b second use imput extend idea wang j r stat soc ser b nonparametr set current regress framework articl covari take discret valu extend approach chang wang statist sinca allow left truncat larg sampl properti propos estim deriv finit sampl perform investig simul studi also appli method heart transplant surviv data

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