Lifetime Data Anal - Comparison of estimators in nested case-control studies with multiple outcomes.

Tópicos

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Resumo

Reuse of controls in a nested case-control (NCC) study has not been considered feasible since the controls are matched to their respective cases. However, in the last decade or so, methods have been developed that break the matching and allow for analyses where the controls are no longer tied to their cases. These methods can be divided into two groups; weighted partial likelihood (WPL) methods and full maximum likelihood methods. The weights in the WPL can be estimated in different ways and four estimation procedures are discussed. In addition, we address modifications needed to accommodate left truncation. A full likelihood approach is also presented and we suggest an aggregation technique to decrease the computation time. Furthermore, we generalize calibration for case-cohort designs to NCC studies. We consider a competing risks situation and compare WPL, full likelihood and calibration through simulations and analyses on a real data example.

Resumo Limpo

reus control nest casecontrol ncc studi consid feasibl sinc control match respect case howev last decad method develop break match allow analys control longer tie case method can divid two group weight partial likelihood wpl method full maximum likelihood method weight wpl can estim differ way four estim procedur discuss addit address modif need accommod left truncat full likelihood approach also present suggest aggreg techniqu decreas comput time furthermor general calibr casecohort design ncc studi consid compet risk situat compar wpl full likelihood calibr simul analys real data exampl

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