Lifetime Data Anal - Estimating heritability for cause specific mortality based on twin studies.

Tópicos

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Resumo

There has been considerable interest in studying the magnitude and type of inheritance of specific diseases. This is typically derived from family or twin studies, where the basic idea is to compare the correlation for different pairs that share different amount of genes. We here consider data from the Danish twin registry and discuss how to define heritability for cancer occurrence. The key point is that this should be done taking censoring as well as competing risks due to e.g.? death into account. We describe the dependence between twins on the probability scale and show that various models can be used to achieve sensible estimates of the dependence within monozygotic and dizygotic twin pairs that may vary over time. These dependence measures can subsequently be decomposed into a genetic and environmental component using random effects models. We here present several novel models that in essence describe the association in terms of the concordance probability, i.e., the probability that both twins experience the event, in the competing risks setting. We also discuss how to deal with the left truncation present in the Nordic twin registries, due to sampling only of twin pairs where both twins are alive at the initiation of the registries.

Resumo Limpo

consider interest studi magnitud type inherit specif diseas typic deriv famili twin studi basic idea compar correl differ pair share differ amount gene consid data danish twin registri discuss defin herit cancer occurr key point done take censor well compet risk due eg death account describ depend twin probabl scale show various model can use achiev sensibl estim depend within monozygot dizygot twin pair may vari time depend measur can subsequ decompos genet environment compon use random effect model present sever novel model essenc describ associ term concord probabl ie probabl twin experi event compet risk set also discuss deal left truncat present nordic twin registri due sampl twin pair twin aliv initi registri

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