Med Biol Eng Comput - Novel non-invasive method of measurement of endothelial function: enclosed-zone flow-mediated dilatation (ezFMD).

Tópicos

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Resumo

Measurement of flow-mediated dilatation (FMD) is the conventional non-invasive method for assessment of endothelial function; however, it requires an expensive ultrasound system and high levels of technical skill. Therefore, we developed a novel method for measurement of endothelial function, namely, measurement of ezFMD. ezFMD estimates the degree of vasodilatation from the oscillation signals transmitted to a sphygmomanometer cuff attached to the upper arm. The objective of this study was to validate the principle underlying the measurement of ezFMD, and to evaluate the repeatability of the ezFMD measurements. We observed the blood vessel behavior and oscillometric pattern in ten subjects. When the cuff was inflated to the level of the mean blood pressure, the oscillation amplitude increased with increasing degree of vasodilatation. In experiment to evaluate the repeatability of the ezFMD measurement, the average difference between the paired measurements was 3.7 %, the standard deviation was 11.5 %, and the average coefficient of variation value for the 11 paired measurements was 23.7 %. These results suggest the validity of the principle underlying the measurement of the ezFMD for the assessment of endothelial function. And, this study suggests that the repeatability of the ezFMD measurements is superior to that of the conventional measurement of FMD.

Resumo Limpo

measur flowmedi dilat fmd convent noninvas method assess endotheli function howev requir expens ultrasound system high level technic skill therefor develop novel method measur endotheli function name measur ezfmd ezfmd estim degre vasodilat oscil signal transmit sphygmomanomet cuff attach upper arm object studi valid principl under measur ezfmd evalu repeat ezfmd measur observ blood vessel behavior oscillometr pattern ten subject cuff inflat level mean blood pressur oscil amplitud increas increas degre vasodilat experi evalu repeat ezfmd measur averag differ pair measur standard deviat averag coeffici variat valu pair measur result suggest valid principl under measur ezfmd assess endotheli function studi suggest repeat ezfmd measur superior convent measur fmd

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