BMC Med Inform Decis Mak - Deficiencies in the transfer and availability of clinical trials evidence: a review of existing systems and standards.

Tópicos

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{ clinic(1479) use(1117) guidelin(835) }
{ decis(3086) make(1611) patient(1517) }
{ care(1570) inform(1187) nurs(1089) }
{ research(1085) discuss(1038) issu(1018) }
{ health(3367) inform(1360) care(1135) }
{ system(1976) rule(880) can(841) }
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{ method(1557) propos(1049) approach(1037) }
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{ data(2317) use(1299) case(1017) }
{ medic(1828) order(1363) alert(1069) }
{ activ(1138) subject(705) human(624) }
{ drug(1928) target(777) effect(648) }
{ method(1969) cluster(1462) data(1082) }
{ can(774) often(719) complex(702) }
{ inform(2794) health(2639) internet(1427) }
{ imag(1057) registr(996) error(939) }
{ sequenc(1873) structur(1644) protein(1328) }
{ method(1219) similar(1157) match(930) }
{ network(2748) neural(1063) input(814) }
{ chang(1828) time(1643) increas(1301) }
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{ featur(1941) imag(1645) propos(1176) }
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{ model(3480) simul(1196) paramet(876) }
{ ehr(2073) health(1662) electron(1139) }
{ research(1218) medic(880) student(794) }
{ patient(2837) hospit(1953) medic(668) }
{ model(2656) set(1616) predict(1553) }
{ age(1611) year(1155) adult(843) }
{ signal(2180) analysi(812) frequenc(800) }
{ cost(1906) reduc(1198) effect(832) }
{ group(2977) signific(1463) compar(1072) }
{ sampl(1606) size(1419) use(1276) }
{ gene(2352) biolog(1181) express(1162) }
{ data(3008) multipl(1320) sourc(1022) }
{ first(2504) two(1366) second(1323) }
{ intervent(3218) particip(2042) group(1664) }
{ time(1939) patient(1703) rate(768) }
{ patient(1821) servic(1111) care(1106) }
{ use(2086) technolog(871) perceiv(783) }
{ analysi(2126) use(1163) compon(1037) }
{ structur(1116) can(940) graph(676) }
{ high(1669) rate(1365) level(1280) }
{ cancer(2502) breast(956) screen(824) }
{ use(976) code(926) identifi(902) }
{ use(1733) differ(960) four(931) }
{ result(1111) use(1088) new(759) }
{ survey(1388) particip(1329) question(1065) }
{ estim(2440) model(1874) function(577) }
{ activ(1452) weight(1219) physic(1104) }
{ method(2212) result(1239) propos(1039) }
{ detect(2391) sensit(1101) algorithm(908) }

Resumo

CKGROUND: Decisions concerning drug safety and efficacy are generally based on pivotal evidence provided by clinical trials. Unfortunately, finding the relevant clinical trials is difficult and their results are only available in text-based reports. Systematic reviews aim to provide a comprehensive overview of the evidence in a specific area, but may not provide the data required for decision making.METHODS: We review and analyze the existing information systems and standards for aggregate level clinical trials information from the perspective of systematic review and evidence-based decision making.RESULTS: The technology currently used has major shortcomings, which cause deficiencies in the transfer, traceability and availability of clinical trials information. Specifically, data available to decision makers is insufficiently structured, and consequently the decisions cannot be properly traced back to the underlying evidence. Regulatory submission, trial publication, trial registration, and systematic review produce unstructured datasets that are insufficient for supporting evidence-based decision making.CONCLUSIONS: The current situation is a hindrance to policy decision makers as it prevents fully transparent decision making and the development of more advanced decision support systems. Addressing the identified deficiencies would enable more efficient, informed, and transparent evidence-based medical decision making.

Resumo Limpo

ckground decis concern drug safeti efficaci general base pivot evid provid clinic trial unfortun find relev clinic trial difficult result avail textbas report systemat review aim provid comprehens overview evid specif area may provid data requir decis makingmethod review analyz exist inform system standard aggreg level clinic trial inform perspect systemat review evidencebas decis makingresult technolog current use major shortcom caus defici transfer traceabl avail clinic trial inform specif data avail decis maker insuffici structur consequ decis proper trace back under evid regulatori submiss trial public trial registr systemat review produc unstructur dataset insuffici support evidencebas decis makingconclus current situat hindranc polici decis maker prevent fulli transpar decis make develop advanc decis support system address identifi defici enabl effici inform transpar evidencebas medic decis make

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