Med Biol Eng Comput - Spinal cord direct current stimulation: finite element analysis of the electric field and current density.

Tópicos

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Resumo

Applied low-intensity direct current (DC) stimulates and directs axonal growth in models of spinal cord injury (SCI) and may have therapeutic value in humans. Using higher electric strengths will probably increase the beneficial effects, but this faces the risk of tissue damage by electricity or toxic reactions at the electrode-tissue interface. To inform the optimisation of DC-based therapeutics, we developed a finite element model (FEM) of the human cervical spine and calculated the electric fields (EFs) and current densities produced by electrodes of different size, geometry and location. The presence of SCI was also considered. Three disc electrodes placed outside the spine produced low-intensity, uneven EFs, whereas the EFs generated by the same electrodes located epidurally were about three times more intense. Changes in electrical conductivity after SCI had little effect on the EF magnitudes. Uniformly distributed EFs were obtained with five disc electrodes placed around the dura mater, but not with a paddle-type electrode placed in the dorsal epidural space. Replacing the five disc electrodes by a single, large band electrode yielded EFs > 5 mV/mm with relatively low current density (2.5 ?A/mm(2)) applied. With further optimisation, epidural, single-band electrodes might enhance the effectiveness of spinal cord DC stimulation.

Resumo Limpo

appli lowintens direct current dc stimul direct axon growth model spinal cord injuri sci may therapeut valu human use higher electr strength will probabl increas benefici effect face risk tissu damag electr toxic reaction electrodetissu interfac inform optimis dcbase therapeut develop finit element model fem human cervic spine calcul electr field ef current densiti produc electrod differ size geometri locat presenc sci also consid three disc electrod place outsid spine produc lowintens uneven ef wherea ef generat electrod locat epidur three time intens chang electr conduct sci littl effect ef magnitud uniform distribut ef obtain five disc electrod place around dura mater paddletyp electrod place dorsal epidur space replac five disc electrod singl larg band electrod yield ef mvmm relat low current densiti amm appli optimis epidur singleband electrod might enhanc effect spinal cord dc stimul

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