Med Biol Eng Comput - Characterization of cellular elastic modulus using structure based double layer model.

Tópicos

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Resumo

The mechanical characterization of cells is important for understanding cellular behavior and physiological functions. We used atomic force microscopy (AFM) to obtain a force-displacement curve and estimate the elastic modulus of hepatocellular carcinoma cells (HEP-G2) utilizing both linear Hertz-Sneddon (HS) and non-linear elastic models. In order to overcome the limitations of HS model, which assumes a linear homogeneous cell body, a cell is modeled as a double-layered body with an outer cytoplasmic layer made mostly of interconnected fibers of cytoskeleton proteins and a nucleus. By disrupting all cytoskeletal protein networks, we estimate the elastic modulus of the core nucleus using FEM for a single ellipsoid. Based on the nucleic modulus and cellular dimensions found by 3D confocal imaging, we develop a novel double-layered cellular (DLC) finite element model. The DLC model provides a more reliable estimate of the elastic modulus of the cell than conventionally used HS model and correlates closely with experimental results.

Resumo Limpo

mechan character cell import understand cellular behavior physiolog function use atom forc microscopi afm obtain forcedisplac curv estim elast modulus hepatocellular carcinoma cell hepg util linear hertzsneddon hs nonlinear elast model order overcom limit hs model assum linear homogen cell bodi cell model doublelay bodi outer cytoplasm layer made most interconnect fiber cytoskeleton protein nucleus disrupt cytoskelet protein network estim elast modulus core nucleus use fem singl ellipsoid base nucleic modulus cellular dimens found d confoc imag develop novel doublelay cellular dlc finit element model dlc model provid reliabl estim elast modulus cell convent use hs model correl close experiment result

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