Med Biol Eng Comput - Dynamics of magnetic particles in cylindrical Halbach array: implications for magnetic cell separation and drug targeting.

Tópicos

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Resumo

Magnetic nanoparticles for therapy and diagnosis are at the leading edge of the rapidly developing field of bionanotechnology. In this study, we have theoretically studied motion of magnetic nano- as well as micro-particles in the field of cylindrical Halbach array of permanent magnets. Magnetic flux density was modeled as magnetostatic problem by finite element method and particle motion was described using system of ordinary differential equations--Newton law. Computations were done for nanoparticles Nanomag-D with radius 65 nm, which are often used in magnetic drug targeting, as well as microparticles DynaBeads-M280 with radius 1.4 microm, which can be used for magnetic separation. Analyzing snapshots of trajectories of hundred magnetite particles of each size in the water as well as in the air, we have found that optimally designed magnetic circuits of permanent magnets in quadrupolar Halbach array have substantially shorter capture time than simple blocks of permanent magnets commonly used in experiments, therefore, such a Halbach array may be useful as a potential source of magnetic field for magnetic separation and targeting of magnetic nanoparticles as well as microparticles for delivery of drugs, genes, and cells in various biomedical applications.

Resumo Limpo

magnet nanoparticl therapi diagnosi lead edg rapid develop field bionanotechnolog studi theoret studi motion magnet nano well microparticl field cylindr halbach array perman magnet magnet flux densiti model magnetostat problem finit element method particl motion describ use system ordinari differenti equationsnewton law comput done nanoparticl nanomagd radius nm often use magnet drug target well microparticl dynabeadsm radius microm can use magnet separ analyz snapshot trajectori hundr magnetit particl size water well air found optim design magnet circuit perman magnet quadrupolar halbach array substanti shorter captur time simpl block perman magnet common use experi therefor halbach array may use potenti sourc magnet field magnet separ target magnet nanoparticl well microparticl deliveri drug gene cell various biomed applic

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