Med Biol Eng Comput - Comparison of spinal cord stimulation profiles from intra- and extradural electrode arrangements by finite element modelling.

Tópicos

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Resumo

Spinal cord stimulation currently relies on extradural electrode arrays that are separated from the spinal cord surface by a highly conducting layer of cerebrospinal fluid. It has recently been suggested that intradural placement of the electrodes in direct contact with the pial surface could greatly enhance the specificity and efficiency of stimulation. The present computational study aims at quantifying and comparing the electrical current distributions as well as the spatial recruitment profiles resulting from extra- and intra-dural electrode arrangements. The electrical potential distribution is calculated using a 3D finite element model of the human thoracic spinal canal. The likely recruitment areas are then obtained using the potential as input to an equivalent circuit model of the pre-threshold axonal response. The results show that the current threshold to recruitment of axons in the dorsal column is more than an order of magnitude smaller for intradural than extradural stimulation. Intradural placement of the electrodes also leads to much higher contrast between the stimulation thresholds for the dorsal root entry zone and the dorsal column, allowing better focusing of the stimulus.

Resumo Limpo

spinal cord stimul current reli extradur electrod array separ spinal cord surfac high conduct layer cerebrospin fluid recent suggest intradur placement electrod direct contact pial surfac great enhanc specif effici stimul present comput studi aim quantifi compar electr current distribut well spatial recruit profil result extra intradur electrod arrang electr potenti distribut calcul use d finit element model human thorac spinal canal like recruit area obtain use potenti input equival circuit model prethreshold axon respons result show current threshold recruit axon dorsal column order magnitud smaller intradur extradur stimul intradur placement electrod also lead much higher contrast stimul threshold dorsal root entri zone dorsal column allow better focus stimulus

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