Med Biol Eng Comput - The effect of aortic wall and aortic leaflet stiffening on coronary hemodynamic: a fluid-structure interaction study.

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Resumo

Pathologies of the aortic valve such as aortic sclerosis are thought to impact coronary blood flow. Recent clinical investigations have observed simultaneous structural and hemodynamic variations in the aortic valve and coronary arteries due to regional pathologies of the aortic valve. The goal of the present study is to elucidate this observed and yet unexplained phenomenon, in which a local pathology in the aortic valve region could potentially lead to the initiation or progression of coronary artery disease. Results revealed a considerable impact on the coronary flow, velocity profile, and consequently shear stress due to an increase in the aortic wall or aortic leaflet stiffness and thickness which concur with clinical observations. The cutoff value of 0.75 for fractional flow reserve was reached when the values of leaflet thickness and aortic wall stiffness were approximately twice and three times their normal value, respectively. Variations observed in coronary velocity profiles as well as wall shear stress suggest a possible link for the initiation of coronary artery disease.

Resumo Limpo

patholog aortic valv aortic sclerosi thought impact coronari blood flow recent clinic investig observ simultan structur hemodynam variat aortic valv coronari arteri due region patholog aortic valv goal present studi elucid observ yet unexplain phenomenon local patholog aortic valv region potenti lead initi progress coronari arteri diseas result reveal consider impact coronari flow veloc profil consequ shear stress due increas aortic wall aortic leaflet stiff thick concur clinic observ cutoff valu fraction flow reserv reach valu leaflet thick aortic wall stiff approxim twice three time normal valu respect variat observ coronari veloc profil well wall shear stress suggest possibl link initi coronari arteri diseas

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