Med Biol Eng Comput - Computer simulation of three-dimensional plaque formation and progression in the carotid artery.

Tópicos

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Resumo

Atherosclerosis is becoming the number one cause of death worldwide. In this study, three-dimensional computer model of plaque formation and development for human carotid artery is developed. The three-dimensional blood flow is described by the Navier-Stokes equation, together with the continuity equation. Mass transfer within the blood lumen and through the arterial wall is coupled with the blood flow and is modeled by a convection-diffusion equation. The low-density lipoproteins transports in lumen of the vessel and through the vessel tissue are coupled by Kedem-Katchalsky equations. The inflammatory process is modeled using three additional reaction-diffusion partial differential equations. Fluid-structure interaction is used to estimate effective wall stress analysis. Plaque growth functions for volume progression are correlated with shear stress and effective wall stress distribution. We choose two specific patients from MRI study with significant plaque progression. Plaque volume progression using three time points for baseline, 3- and 12-month follow up is fitted. Our results for plaque localization correspond to low shear stress zone and we fitted parameters from our model using nonlinear least-square method. Determination of plaque location and composition, and computer simulation of progression in time for a specific patient shows a potential benefit for the prediction of disease progression. The proof of validity of three-dimensional computer modeling in the evaluation of atherosclerotic plaque burden may shift the clinical information of MRI from morphological assessment toward a functional tool. Understanding and prediction of the evolution of atherosclerotic plaques either into vulnerable or stable plaques are major tasks for the medical community.

Resumo Limpo

atherosclerosi becom number one caus death worldwid studi threedimension comput model plaqu format develop human carotid arteri develop threedimension blood flow describ navierstok equat togeth continu equat mass transfer within blood lumen arteri wall coupl blood flow model convectiondiffus equat lowdens lipoprotein transport lumen vessel vessel tissu coupl kedemkatchalski equat inflammatori process model use three addit reactiondiffus partial differenti equat fluidstructur interact use estim effect wall stress analysi plaqu growth function volum progress correl shear stress effect wall stress distribut choos two specif patient mri studi signific plaqu progress plaqu volum progress use three time point baselin month follow fit result plaqu local correspond low shear stress zone fit paramet model use nonlinear leastsquar method determin plaqu locat composit comput simul progress time specif patient show potenti benefit predict diseas progress proof valid threedimension comput model evalu atherosclerot plaqu burden may shift clinic inform mri morpholog assess toward function tool understand predict evolut atherosclerot plaqu either vulner stabl plaqu major task medic communiti

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