Med Biol Eng Comput - Characterization of skin dermis microcirculation in flow-mediated dilation using optical sensor with pressurization mechanism.


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Blood flows out of microvessels in the dermis when pressure higher than arterial blood pressure is applied to the fingertip, and subsequently re-flows into the microcirculation when pressure is released. Both the blood outflow and the reflow characteristics of microcirculation under pressurization are associated with microvasculature, blood and blood pressure. This study describes a novel method of measuring blood inflow and outflow characteristics of dermis microcirculation. An optical sensor, which is furnished with a 571 nm wavelength light source and a photodetector, is pressed to the skin surface using a pressure higher than the human subject's systolic arterial pressure. Hemoglobin concentration by change of the blood flow amount is estimated by the Beer-Lambert law. This method is applied to the measurement of blood inflow and outflow characteristics of microcirculation caused by reactive hyperemia after ischemia with duration of 5 min. Among three parameters evaluated, the one relating to the amplitude of pulsation shows a close correlation with conventional plethysmography, while the other two show varying time responses. Our method provides a new and useful insight into pathophysiology in health and disease conditions and may help researchers better understand the underlying mechanisms of numerous microcirculation-influenced diseases and medical conditions.

Resumo Limpo

blood flow microvessel dermi pressur higher arteri blood pressur appli fingertip subsequ reflow microcircul pressur releas blood outflow reflow characterist microcircul pressur associ microvasculatur blood blood pressur studi describ novel method measur blood inflow outflow characterist dermi microcircul optic sensor furnish nm wavelength light sourc photodetector press skin surfac use pressur higher human subject systol arteri pressur hemoglobin concentr chang blood flow amount estim beerlambert law method appli measur blood inflow outflow characterist microcircul caus reactiv hyperemia ischemia durat min among three paramet evalu one relat amplitud pulsat show close correl convent plethysmographi two show vari time respons method provid new use insight pathophysiolog health diseas condit may help research better understand under mechan numer microcirculationinfluenc diseas medic condit

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